Consistent rewarding or aversive effects of the electrical stimulation of the lateral parabrachial complex

Simon, Maria J.; Zafra, María A.; Molina, Filomena; Puerto, Amadeo

doi:10.1016/j.bbr.2008.02.036

Cited by 13 publications

(20 citation statements)

References 75 publications

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“…Under these circumstances, animals develop specific preferences for the flavor stimuli associated with electrical stimulation of the LPBe, regardless of the place of their presentation, allowing dissociation between the two stimulus indexes (place/ flavor). It was previously reported that this stimulation generated preferences for associated taste stimuli, but the flavors were presented in fixed positions [20,23]. Likewise, LPBe lesions were previously found to interrupt the association between a flavor and the intragastric infusion of rewarding foods [11] and between a flavor and the administration of aversive products [9], but the flavors were always presented in fixed positions in these studies.…”

Section: Discussionmentioning

confidence: 78%

“…Ongoing electrical stimulation of the LPBe generates concurrent place preferences ( [20][21][22][23], the first part of this study). An additional and novel finding of this study is that electrical stimulation of this pontine subnucleus immediately after exposure to the stimulus can also induce standard conditioned place preferences and specific flavor preferences; this result was not obtained in neurologically intact (non-stimulated) control rats.…”

Section: Discussionmentioning

confidence: 99%

“…The procedure used in the present study implies temporal contiguity between the stimuli (taste/place and brain stimulation) and also means that the animals benefit from an increase in the number of trials ( [20][21][22][23], present study). These results are similar to those obtained in certain stressful situations (acute or chronic stress, emotionally arousing material, and even drug addiction), which induce implicit learning modalities (learned implicit behaviors) that promote stereotyped behaviors and may involve the participation of certain visceral pathways [54][55][56].…”

Section: Discussionmentioning

confidence: 99%

“…Ongoing electrical stimulation of the LPBe induced concurrent place preferences for the associated compartment in a rectangular maze [20][21][22]. Likewise, conditioned taste preferences were induced by LPBe electrical stimulation in a flavor discrimination task that repeatedly presented taste-olfactory stimuli in a given place [20,23].…”

Section: Introductionmentioning

confidence: 99%

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Conditioned Taste and Place Preferences Induced by Electrical Stimulation of the External Lateral Parabrachial Nucleus: A General Reinforcing Mechanism?

Simon¹,

Cremades²,

Puerto³

2013

JBBS

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This study examined the stimulus specificity of external lateral parabrachial (LPBe) rewarding stimulation by using two identical learning procedures that may dissociate conditioned reinforcement to either the place or the flavor stimulus. Animals were presented with two distinct flavors in two different positions (left and right) that were varied throughout the experimental sessions. In the first experiment, LPBe stimulation was associated with one or other flavor, while in the second it was conditioned to one or other place in which these flavors were offered. The results show that, despite stimulus interferences, the animals develop specific conditioned preferences for the flavor stimuli (experiment 2A), and also for the place of their presentation (experiment 2B). These data are discussed in the context of brain reward systems and the biological constraints that characterize some learning modalities.

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Section: Discussionmentioning

confidence: 78%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Conditioned Taste and Place Preferences Induced by Electrical Stimulation of the External Lateral Parabrachial Nucleus: A General Reinforcing Mechanism?

Simon¹,

Cremades²,

Puerto³

2013

JBBS

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“…More specifically, the PBLe subnucleus appears to contain intermingled cell populations that process rewarding and aversive information, as also observed in other brain areas (Hawkins et al 1983, O`Doherty et al 2001. Thus, electrical stimulation of the PBLe induces consistent aversion or preference behavior towards associated stimuli in different animals (Simón et al 2007(Simón et al , 2008, and its effect on preference behavior is subject to tolerance after repeated activation .…”

Section: Introductionmentioning

confidence: 71%

Tiapride prevents the aversive but not the rewarding effect induced by parabrachial electrical stimulation in a place preference task

Hurtado¹,

Cremades²,

Puerto³

2017

Acta Neurobiologiae Experimentalis

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The parabrachial complex has been related to the processing of both rewarding and aversive signals. This pontine area is activated after the gastrointestinal administration of rewarding nutrients, in taste aversion learning, and in response to the reinforcing and aversive effects of some drugs of abuse. Electrical stimulation of this region can induce, in different animals, preference or aversion behaviors towards a place in a rectangular three-chamber maze task. This study examined the effect of tiapride, a D2/D3 receptor antagonist, on the aversive or rewarding effects induced by electrical stimulation of the external lateral parabrachial subnucleus (NLPBe). As previously observed, administration of tiapride interrupted the aversive effect induced by NLPBe electrical stimulation. However, in contrast to the effects of dopamine antagonists on other rewarding systems, tiapride did not impair the place preference induced by NLPBe stimulation, an activation effect that is subject to tolerance. Tiapride administration also appeared to have no effect on the horizontal motor activity (crossings) of the electrically stimulated animals. We discuss the specific relevance of parabrachial reward with respect to other reinforcing brain components or systems, especially in relation to the preference effect of drugs of abuse, such as opiates, after dopamine antagonist administration.

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Conditioned place preference induced by electrical stimulation of the insular cortex: effects of naloxone

2013

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The insular cortex has been related to various sensory, regulatory, and learning processes, which frequently include affective-emotional components. The objective of this study was to investigate the possibility of inducing reinforcing effects by electrical stimulation of this cortical region in Wistar rats. Concurrent conditioned place preference tasks were conducted for this purpose, using two rectangular mazes that differed in dimensions, texture, and spatial orientation. A significant correlation was found in the preferences induced by insular cortex electrical stimulation between the two mazes. Animals showed consistent preference or avoidance behaviors associated with simultaneous insular cortex stimulation. No electrical self-stimulation was achieved. In a second experiment, animals that showed consistent place preference after the simultaneous insular cortex electrical stimulation were administered with 4 mg/ml/kg of naloxone. The results revealed that this opiate antagonist blocked concurrent place preference learning when the task was conducted in a new maze but not when it was conducted in the same maze as that in which the animals had learned the task. These results are discussed in terms of the participation of the insular cortex in various reward and aversion modalities.

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Consistent rewarding or aversive effects of the electrical stimulation of the lateral parabrachial complex

Cited by 13 publications

References 75 publications

Conditioned Taste and Place Preferences Induced by Electrical Stimulation of the External Lateral Parabrachial Nucleus: A General Reinforcing Mechanism?

Conditioned Taste and Place Preferences Induced by Electrical Stimulation of the External Lateral Parabrachial Nucleus: A General Reinforcing Mechanism?

Tiapride prevents the aversive but not the rewarding effect induced by parabrachial electrical stimulation in a place preference task

Conditioned place preference induced by electrical stimulation of the insular cortex: effects of naloxone

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