Conspectus on Nanotechnology in Oral Cancer Diagnosis and Treatment

Ankathil, Ravindran; Nair, Vinod S.; Ravindran, Anjana; Ravindran, Ranjana

doi:10.1016/b978-0-323-52725-5.00003-4

Cited by 4 publications

(2 citation statements)

References 155 publications

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“…In the field of nanomedicine nanoparticles are exploited as biomarkers, biosensors, for imaging, drug delivery and many others and as mentioned above many nanoparticles are known to possess nanozyme like characteristics. This section of the review discusses the role and application of nanozymes in oral cancer detection, diagnosis, therapeutics and in regeneration of tissues [ 9 ].…”

Section: Nanozymes In Oral Cancermentioning

confidence: 99%

Role of Nanozymes in Oral Cancer the Road Ahead

et al. 2022

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Oral cancer is a result of diverse interactions in the tumor microenvironment (TME), genetic alterations along with associated risk factors such as lifestyle and microbial infections. Various modalities are employed in the diagnosis and therapeutics of oral cancer. Nanozymes which are artificial enzymes have a great potential in the diagnostic and therapeutic approach of tumors. They have enormous advantages compared to natural enzymes and possess inherent biological and physical properties. A web-based search was performed via the Google scholar, PubMed database, Web of Science with keywords nanozymes, nanoparticles in cancer and oral cancer. The other keywords used were diagnosis, therapy, TME, microbiome, molecular alterations, biosensor, targeted therapy, imaging and tissue regeneration. Original research studies, reviews, case reports published from 2012 to 2022 were included to appraise different subsections. An absolute lack of literature on nanozymes was observed in oral cancer. The present review is the first attempt to describe the role and application of nanozymes in oral cancer by correlating its outcome in tumor biology and biomedical research. Rapid development of nanotechnology has created a paradigm shift in cancer diagnosis and therapeutics. Nanozymes with novel designs can be anticipated in the future in oral cancer management. Supplementary Information The online version contains supplementary material available at 10.1007/s11244-022-01729-9.

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Section: Nanozymes In Oral Cancermentioning

confidence: 99%

Role of Nanozymes in Oral Cancer the Road Ahead

et al. 2022

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“…Oral Cancer (OC) is one of the most prevalent forms of cancer in both sexes and it is the sixth most frequently occurring malignancy worldwide. 1,2 The development of OC is attributed to several processes that mainly include the accumulation of genetic and epigenetic changes that are modulated by risk factors and genetic predisposition. 3 Several oral cancer risk factors are gender, age, consumption of alcohol, use of tobacco, lack of oral hygiene, radiation, infection by the human papillomavirus, exposure to asbestos, and inflammation.…”

Section: Introductionmentioning

confidence: 99%

Troxerutin, a Bioflavonoid Exhibits Oxidative Stress-induced Cytotoxic Effects on KB Cells

Li¹,

Ding²,

Xi³

2023

Ind. J. Pharm. Edu. Res

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MATERIALS AND METHODS Cell LineHuman oral epidermal carcinoma cell line KB was used in this study. These cancer cells were cultured using DMEM culture media supplemented with 5% heat-inactivated FBS and 1% Penicillin-Streptomycin at 37°C and 5% CO 2 atmosphere. After ABSTRACT Background: The prevalence of oral cancer is high and it is the sixth most occurring cancer in the world. Some of the drugs used to treat oral cancer cause adverse effects and are resistant to treatment. Objectives: This study was designed and performed to evaluate the cytotoxic and anti-cancerous effects of troxerutin. Materials and Methods: Cell proliferation, cell viability, and morphological analysis were performed with different doses of troxerutin. Once the IC 50 value was obtained, doses were fixed and nitric oxide and lipid peroxidation were measured. Qualitative analysis of ROS and mitochondrial membrane potential was performed using 2′,7′-dichlorofluorescein methods and rhodamine 123 fluorescent staining respectively. Results: Troxerutin caused cytotoxicity and reduced cell viability. The IC 50 value was 50 μg/ml. Morphological analysis revealed KB cells suffered after troxerutin treatment. Nitric oxide and TBARS levels were elevated. ROS concentration increased and mitochondrial membrane potential diminished with a higher concentration of the drug. Conclusion: Troxerutin exhibits an anti-cancer effect and can act as a NO-donating and ROS-promoting compound aiding in chemotherapy.

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Applications of Nanoscience and Nanotechnology in Oral Cancer: A Review

Kasaai¹

2023

Materials Horizons: From Nature to Nanomaterials

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Conspectus on Nanotechnology in Oral Cancer Diagnosis and Treatment

Cited by 4 publications

References 155 publications

Role of Nanozymes in Oral Cancer the Road Ahead

Role of Nanozymes in Oral Cancer the Road Ahead

Troxerutin, a Bioflavonoid Exhibits Oxidative Stress-induced Cytotoxic Effects on KB Cells

Applications of Nanoscience and Nanotechnology in Oral Cancer: A Review

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