Constant light alters serum hormone levels related to thyroid function in male CD-1 mice

Maroni, Marissa J.; Capri, Kimberly M.; Cushman, Alexis V; Pina, Isabella K. Monteiro De; Chasse, Madison H; Seggio, Joseph A.

doi:10.1080/07420528.2018.1488259

Cited by 20 publications

(15 citation statements)

References 48 publications

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“…This effect was even more apparent at higher intensities since 50% of mice were arrhythmic after exposure to >500 lx [ 92 ]. These findings were supported by other studies where the free-running rhythm with a lengthened period and the reduced strength of the rhythm appeared under LL of ≥180 and 100 lx [ 61 , 75 ], while the arrhythmicity occurred under much higher intensity (~580 lx) [ 72 ]. On the other hand, mice exposed to low illumination also developed arrhythmic locomotor activity without changes in total 24 h activity, but the experiment lasted two times longer [ 62 ].…”

Section: Locomotor Activity Food Intake and Body Masssupporting

confidence: 83%

“…Constant light did not influence total 24 h food intake [51,61,62,[73][74][75], but the daily variation was suppressed mostly due to increased food consumption in mice during the subjective day [51,61,62,73,74]. On the other hand, total food intake was reduced in mice fed a high-fat diet [61].…”

Section: Food Intake and Body Mass Under Constant Lightmentioning

confidence: 88%

“…It is known that feeding during an inappropriate phase of the day can misalign peripheral clocks, as well as the expression of metabolic genes and can disrupt energy balance, causing increased body weight gain [100]. CD-1 mice could be more resilient to LL, since, to our knowledge, it is the only strain without changes in glucose levels or glucose tolerance [75], or the potential effects of LL were not detected due to the chosen sampling time-point.…”

Section: Glucose and Lipid Metabolism Under Constant Lightmentioning

confidence: 97%

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Differential Effects of Constant Light and Dim Light at Night on the Circadian Control of Metabolism and Behavior

Rumanova

Okuliarova

Zeman

2020

IJMS

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The disruption of circadian rhythms by environmental conditions can induce alterations in body homeostasis, from behavior to metabolism. The light:dark cycle is the most reliable environmental agent, which entrains circadian rhythms, although its credibility has decreased because of the extensive use of artificial light at night. Light pollution can compromise performance and health, but underlying mechanisms are not fully understood. The present review assesses the consequences induced by constant light (LL) in comparison with dim light at night (dLAN) on the circadian control of metabolism and behavior in rodents, since such an approach can identify the key mechanisms of chronodisruption. Data suggest that the effects of LL are more pronounced compared to dLAN and are directly related to the light level and duration of exposure. Dim LAN reduces nocturnal melatonin levels, similarly to LL, but the consequences on the rhythms of corticosterone and behavioral traits are not uniform and an improved quantification of the disrupted rhythms is needed. Metabolism is under strong circadian control and its disruption can lead to various pathologies. Moreover, metabolism is not only an output, but some metabolites and peripheral signal molecules can feedback on the circadian clockwork and either stabilize or amplify its desynchronization.

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Section: Locomotor Activity Food Intake and Body Masssupporting

confidence: 83%

Section: Food Intake and Body Mass Under Constant Lightmentioning

confidence: 88%

Section: Glucose and Lipid Metabolism Under Constant Lightmentioning

confidence: 97%

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Differential Effects of Constant Light and Dim Light at Night on the Circadian Control of Metabolism and Behavior

Rumanova

Okuliarova

Zeman

2020

IJMS

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“…Regardless of the previously listed strain differences found in their responses to continuous light exposure, this study provides additional evidence that LL can produce negative metabolic effects overall, including increased liver triglycerides and different fT4 levels, despite similar levels of food consumption. A recent study from our lab also reported altered fT4 and other hormone levels related to obesity and thyroid function in male CD-1 mice exposed to LL, even in the absence of weight gain or increased food consumption (Maroni et al, 2018). In summary, these results illustrate that circadian disruption can lead to significant changes in metabolic phenotypes even if a healthy diet is consumed.…”

Section: Discussionsupporting

confidence: 71%

Male C57BL6/N and C57BL6/J Mice Respond Differently to Constant Light and Running-Wheel Access

Capri

Maroni

Deane

et al. 2019

Front. Behav. Neurosci.

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Previous studies have shown that exposure to circadian disruption produces negative effects on overall health and behavior. More recent studies illustrate that strain differences in the behavioral and physiological responses to circadian disruption exist, even if the strains have similar genetic backgrounds. As such, we investigated the effects of constant room-level light (LL) with running-wheel access on the behavior and physiology of male C57BL6/J from Jackson Laboratories and C57BL6/N from Charles River Laboratories mice. Mice were exposed to either a 12:12 light-dark (LD) cycle or LL and given either a standard home cage or a cage with a running-wheel. Following 6 weeks of LD or LL, their response to behavioral assays (open-field, light-dark box, novel object) and measures of metabolism were observed. Under standard LD, C57BL6/J mice exhibited increased locomotor activity and reduced exploratory behavior compared to C57BL6/N mice. In LL, C57BL6/J mice had greater period lengthening and increased anxiety, while C57BL6/N mice exhibited increased weight gain and no change in exploratory behavior. C57BL6/J mice also decreased exploration with runningwheel access while C57BL6/N mice did not. These results further demonstrate that C57BL/6 substrains exhibit different behavioral and physiological responses to circadian disruption and wheel-running access.

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“…In hamsters under short-day photoperiod, low levels of ALAN elevated the levels of thyroid-stimulating-hormone (TSH) receptors causing advanced W b and gonadal growth [112]. Continuous exposure to ALAN decreased TSH, but increased both T3 and T4 in mice [113]. In birds, long-term exposure to ALAN increased both the blood levels of the thyroid hormones and W b [114].…”

Section: Physiological and Epigenetic Responses To Melatonin And Thyrmentioning

confidence: 99%

Consequences of Artificial Light at Night: The Linkage between Chasing Darkness Away and Epigenetic Modifications

Haim¹,

Sinam²,

Zubidat³

2019

Epigenetics

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Epigenetics is an important tool for understanding the relation between environmental exposures and cellular functions, including metabolic and proliferative responses. At our research center, we have devolved a mouse model for characterizing the relation between exposure to artificial light at night (ALAN) and both global DNA methylation (GDM) and breast cancer. Generally, the model describes a close association between ALAN and cancer responses. Cancer responses are eminent at all light spectra, with the prevalent manifestation at the shorter end of the visible spectrum. ALAN-induced pineal melatonin suppression is the principal candidate mechanism mediating the environmental exposure at the molecular level by eliciting aberrant GDM modifications. The carcinogenic potential of ALAN can be ameliorated in mice by exogenous melatonin treatment. In contrast to BALB/c mice, humans are diurnal species, and thus, it is of great interest to evaluate the ALAN-melatonin-GDM nexus also in a diurnal mouse model. The fat sand rat (Psammomys obesus) provides an appropriate model as its responses to photoperiod are comparable to humans. Interestingly, melatonin and thyroxin have opposite effects on GDM levels in P. obesus. Melatonin, GDM levels, and even thyroxin may be utilized as novel biomarkers for detection, staging, therapy, and prevention of breast cancer progression.

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Constant light alters serum hormone levels related to thyroid function in male CD-1 mice

Cited by 20 publications

References 48 publications

Differential Effects of Constant Light and Dim Light at Night on the Circadian Control of Metabolism and Behavior

Differential Effects of Constant Light and Dim Light at Night on the Circadian Control of Metabolism and Behavior

Male C57BL6/N and C57BL6/J Mice Respond Differently to Constant Light and Running-Wheel Access

Consequences of Artificial Light at Night: The Linkage between Chasing Darkness Away and Epigenetic Modifications

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