Abstract-In this letter, we consider the trans-modulation design for the decode-and-forward relay networks. We propose to reassign the constellation points at the relay nodes to minimize the symbol error rate (SER) at the destination node. The proposed trans-modulation scheme can significantly improve the system SER performance without increasing the complexity of the system, especially when the relays are close to the source. For this case, improvements of about 2 dB for 16-QAM constellation and about 3 dB for 64-QAM constellation are achieved for the single-relay case.Index Terms-Constellation design, decode-and-forward protocol, wireless relay networks.