Constipation Treatment in Neurological Disorders

Gallelli, Luca; Pirritano, Domenico; Palleria, Caterina; Giovambattista, De Sarro

doi:10.5772/29813

Cited by 3 publications

(4 citation statements)

References 105 publications

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“…Stroke Population: Prevalence of Constipation after Stroke is 30% to 60% [7]. In a study from China [8] (n = 723) post stroke constipation was noted in 34.6%.…”

Section: Constipation: Numbersmentioning

confidence: 99%

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Stroke and Constipation<br/>—Coincidence or Interrelated?

Kasaraneni¹,

Hayes²

2014

Health

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Emile Gautier once said, "Freedom of the bowels is the most precious, perhaps even the most essential, of all freedoms-one without which little can be accomplished." This paper will explore the neuronal physiology, pathophysiology, theories regarding the correlation between stroke and constipation along with a few treatment options. Patients often recovering from stroke complain of constipation and it is most likely attributed to changes in diet, ambulation, or fluid balance. However, there are not many studies to reflect the correlation between other less significant symptoms and stroke presentation.

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“…Stroke Population: Prevalence of Constipation after Stroke is 30% to 60% [7]. In a study from China [8] (n = 723) post stroke constipation was noted in 34.6%.…”

Section: Constipation: Numbersmentioning

confidence: 99%

“…The development of constipation predicts a poor outcome at 12 weeks in patients with moderately severe stroke [9]. New onset constipation occurs in 30% of hemiplegic patients and has no relationship with the site or severity of stroke [7].…”

Section: Constipation: Numbersmentioning

confidence: 99%

Stroke and Constipation<br/>—Coincidence or Interrelated?

Kasaraneni¹,

Hayes²

2014

Health

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“…Drugs having anticholinergic effect, antidepressants, oral iron supplements, aluminum-containing compounds, clonidine, calcium antagonists, and ganglionic blockers, which reduce smooth muscle contractility, can also cause constipation. [11][12][13] Constipation is a predisposing factor to colorectal disorders such as enlarged hemorrhoids and colorectal cancer. 14 Chronic constipation significantly compromises health-related quality of life.…”

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confidence: 99%

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confidence: 99%

Laxative Activities of 80% Methanolic Extract of the Leaves of Grewia ferruginea Hochst Ex A Rich in Mice

Tessema

Wubneh

Asrie

2020

J Evid Based Complementary Altern Med

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Background. There are numerous medicinal plants including the leaves of Grewia ferruginea used as traditional medicine for the treatment of constipation. This study was conducted to evaluate the laxative activity of the leaves of G ferruginea. Methods. The laxative activity of the leaves of G ferruginea was tested using 3 models: laxative activity, gastrointestinal motility, and gastrointestinal secretion tests. The effect of the plant extract on mean number of feces, fecal water content, ratio of intestinal distance traveled by the charcoal meal and intestinal fluid accumulation were evaluated and analyzed. Results. Significant increase was observed in the mean weight of wet fecal matter at 200 (1.00 ± 0.03 g, P < .05) and 400 mg/kg (1.01 ± 0.02 g, P < .01), relative to loperamide constipated negative control group. Similarly, percent fecal water content was significantly improved in extract treated groups at 100 mg/kg (52.10% ± 2.04%, P < .05), 200 mg/kg (54.02% ± 2.15%, P < .01), and 400 mg/kg (54.25% ± 2.50%, P < .01) compared with the negative control group. The gastroinestinal transit ratio was also significantly increased with 200 mg/kg ( P < .01) and 400 mg/kg ( P < .001) of the extract relative to the constipated negative control. The crude extract showed significant increase in intestinal fluid accumulation at 200 mg/kg (0.48 ± 0.07 g, P < .05) and 400 mg/kg (0.51 ± 0.08 g, P < .01) compared with the negative control. Conclusion. The results of the present study indicated that 80% methanol extract of the leaves of G ferruginea possessed significant laxative activity. As such, this study corroborates the traditional claim of using G ferruginea in the treatment of constipation.

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