Constituent Composition and Biological Activity of Essential Oil from Pimpinella thellungiana

Suleimen, E. M.; Ibataev, Zh. A.; Iskakova, Zh. B.; Дудкин, Р. В.; Горовой, П. Г.; Аистова, Е. В.

doi:10.1007/s10600-017-1940-4

Cited by 8 publications

(5 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The chemical composition of essential oils produced by a number of Dracocephalum species have been reported, especially D. moldavica and D. kotschyi , mostly because of their important value as traditional medical herbs [19,20,21,27,28,31,32]. Suleimen et al [26] investigated the chemical composition of D. peregrinum and detected 1, 8-cineol (synonym for eucalyptol, 18.5%), α-pinene (8.4%), limonene (5.8%), β-caryophyllene oxide (5.5%), and spathulenol (3.3%) as the major constituents; however, the major constituents of some other Dracocephalum species differ greatly from D. integrifolium . Mahmood et al [12] found citronellol (74.9%), Citronellal (6.7%) and Citronellyl formate (6.7%) were abundant in D. heterophyllum oil; Nezhadali et al [18] reported that the major constituents of the essential oil obtained from D. subcapitatum were geranial (63.4%), limonene (23.4%), p-Menth-1-en-9-ol (4.4%) and caryophyllene E (4.3%).…”

Section: Discussionmentioning

confidence: 99%

“…A literature survey of the chemical composition of essential oils produced by Dracocephalum plants revealed the presence of remarkable variations among their major constituents [12]. These oils were found to possess various biological activities such as antimicrobial [13,14,15,16,17,18,19,20], antioxidant [13,17,19,21,22,23], insecticidal [24,25], phytotoxic [26,27], cytotoxic [17], antispasmodic [28] and antinociceptive [29] activity.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Chemical Composition, Phytotoxic, Antimicrobial and Insecticidal Activity of the Essential Oils of Dracocephalum integrifolium

Zhou

Cui

Zhang

et al. 2019

Toxins

View full text Add to dashboard Cite

The present investigation studied the chemical composition of the essential oils extracted from Dracocephalum integrifolium Bunge growing in three different localities in northwest China and evaluated the phytotoxic, antimicrobial and insecticidal activities of the essential oils as well as their major constituents, i.e., sabinene and eucalyptol. GC/MS analysis revealed the presence of 21–24 compounds in the essential oils, representing 94.17–97.71% of the entire oils. Monoterpenes were the most abundant substances, accounting for 85.30–93.61% of the oils; among them, sabinene (7.35–14.0%) and eucalyptol (53.56–76.11%) were dominant in all three oils, which occupied 67.56–83.46% of the total oils. In general, phytotoxic bioassays indicated that the IC50 values of the oils and their major constituents were below 2 μL/mL (1.739–1.886 mg/mL) against Amaranthus retroflexus and Poa annua. Disc diffusion method demonstrated that the oils and their major constituents possessed antimicrobial activity against Bacillus subtilis, Pseudomonas aeruginosa, Escherichia coli, Saccharomyces cerevisiae, and Candida albicans, with MIC values ranging from 5–40 μL/mL (4.347–37.712 mg/mL). The oils, sabinene and eucalyptol also exhibited significant pesticidal activity, with the mortality rates of Aphis pomi reaching 100% after exposing to 10 μL oil/petri dish (8.694–9.428 mg/petri dish) for 24 h. To the best of our knowledge, this is the first report on the chemical composition, phytotoxic, antimicrobial and insecticidal activity of the essential oils extracted from D. integrifolium; it is noteworthy to mention that this is also the first report on the phytotoxicity of one of the major constituents, sabinene. Our results imply that D. integrifolium oils and sabinene have the potential value of being further exploited as natural pesticides.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Chemical Composition, Phytotoxic, Antimicrobial and Insecticidal Activity of the Essential Oils of Dracocephalum integrifolium

Zhou

Cui

Zhang

et al. 2019

Toxins

View full text Add to dashboard Cite

show abstract

“…Recently, researchers also conducted profound studies on the oil of domestic Pimpinella plants. X. W. Xu [ 53 ] and E. M. Suleimen et al [ 54 ] extracted the oil of P. diversifolia and P. thellungiana and identified 19 and 16 terpenoids, respectively.…”

Section: Phytochemistrymentioning

confidence: 99%

Emerging Biopharmaceuticals from Pimpinella Genus

Cao

Hassan

et al. 2023

Molecules

View full text Add to dashboard Cite

Evolved over eons to encode biological assays, plants-derived natural products are still the first dawn of drugs. Most researchers have focused on natural compounds derived from commonly used Pimpinella species, such as P. anisum, P. thellungiana, P. saxifrage, and P. brachycarpa, to investigate their antioxidant, antibacterial, and anti-inflammatory properties. Ethnopharmacological studies demonstrated that the genus Pimpinella has the homology characteristics of medicine and food and mainly in the therapy of gastrointestinal dysfunction, respiratory diseases, deworming, and diuresis. The natural product investigation of Pimpinella spp. revealed numerous natural products containing phenylpropanoids, terpenoids, flavonoids, coumarins, sterols, and organic acids. These natural products have the potential to provide future drugs against crucial diseases, such as cancer, hypertension, microbial and insectile infections, and severe inflammations. It is an upcoming field of research to probe a novel and pharmaceutically clinical value on compounds from the genus Pimpinella. In this review, we attempt to summarize the present knowledge on the traditional applications, phytochemistry, and pharmacology of more than twenty-five species of the genus Pimpinella.

show abstract

“…Trichomonas vaginalis is a protozoan that causes human trichomoniasis, the most common non‐viral sexually transmitted infection (STI), affecting approximately 278 million people worldwide (Fakhrieh‐Kashan et al., 2018 ; Hashemi et al., 2021 ; WHO 2012 ). This parasite can cause urinary tract infection in men and, especially in women, provokes vaginal discharge, dysuria, itching, irritation of the vulva, and abdominal pain (Gutierrez, 2000 ; Moodley et al., 2002 ).…”

Section: Introductionmentioning

confidence: 99%

“…It has been described as the presence of Dracocephalum essential oil as a major constituent with good pharmacological properties (Khamesipour et al, 2022;Mahmood et al, 2005). In addition, numerous studies showed that these oils present important effects acting as antioxidants (Ehsani et al, 2017;Fallah et al, 2018;Sonboli et al, 2012;Zhang et al, 2008), insecticidal (Chu et al, 2011;Özek et al, 2016), phytotoxic (Jalaei et al, 2015;Suleimen et al, 2017), cytotoxic (Sonboli et al, 2012), antinociceptive (Golshani et al, 2004), antispasmodic (Sadraei et al, 2015), antimicrobial (Ehsani et al, 2017;Lee et al, 2007) and antiparasitic (Ghanadian et al, 2021;Khamesipour et al, 2020;Nekoei et al, 2022). D. kotschyi is a wild-growing flowering plant of Dracocephalum species and is commonly found in southwestern Asia.…”

Section: Introductionmentioning

confidence: 99%

Induction of apoptosis by essential oil of Dracocephalum kotschyi on Trichomonas vaginalis

Dehkordi

Esmaeilifallah

Kalantari

et al. 2022

Veterinary Medicine & Sci

View full text Add to dashboard Cite

Background Trichomonas vaginalis is a protist parasite that causes trichomoniasis, a sexually transmitted disease. Metronidazole is the current treatment for trichomoniasis. However, this drug can provoke severe side effects, and some strains present resistance, making the development of alternative treatments for trichomoniasis urgent. Objectives We investigate the use of essential oil obtained from Dracocephalum kotschyi on T. vaginalis. D. kotschyi has antispasmodic and analgesic properties and is well known in Iran. Methods The essential oil was obtained by hydrodistillation from 1000 g of the powdered plant. Gas chromatography‐mass spectrometry analysis was used for the chemical composition of the essential oil, and 11 substances were identified, corresponding to 91.5% of the oil. Copaene (22.15%), Methyl geranate (16.31%), Geranial (13.78%) and Carvone (11.34%) were the main substances. A cell viability test was used to determine the percentage of growth inhibition (GI%) and the half‐maximal inhibitory concentration (IC50) on T. vaginalis after incubation with the prepared essential oil. Results The oil induced an IC50 of 84.07 µg/ml after 24 h contact with trophozoites. Cytotoxicity was determined by MTT assay on the J774.A1 haematopoietic cell line. In addition, the initial stage of apoptosis was assayed using the fluorescein isothiocyanate Annexin V Apoptosis Detection Kit. Evaluation of the in vitro anti‐trichomonal properties of D. kotschyi essential oils showed that it effectively induces apoptosis on T. vaginalis between 100 and 700 µg/ml after 48 h without toxicity on haematopoietic cells, suggesting that D. kotschyi essential oil can induce programmed death in T. vaginalis. Conclusions The anti‐trichomonal properties of D. kotschyi essential oil indicate that they could be suitable for new pharmacologic studies after new tests with human vaginal epithelial cells.

show abstract

Constituent Composition and Biological Activity of Essential Oil from Pimpinella thellungiana

Cited by 8 publications

References 2 publications

Chemical Composition, Phytotoxic, Antimicrobial and Insecticidal Activity of the Essential Oils of Dracocephalum integrifolium

Chemical Composition, Phytotoxic, Antimicrobial and Insecticidal Activity of the Essential Oils of Dracocephalum integrifolium

Emerging Biopharmaceuticals from Pimpinella Genus

Induction of apoptosis by essential oil of Dracocephalum kotschyi on Trichomonas vaginalis

Contact Info

Product

Resources

About