Constituent Composition and Biological Activity of Essential Oil from Cousinia alata

Suleimen, E. M.; Zhanzhaksina, A. Sh.; Sisengalieva, G. G.; Iskakova, Zh. B.; Ishmuratova, Margarita

doi:10.1007/s10600-018-2420-1

Cited by 4 publications

(4 citation statements)

References 4 publications

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“…is plant grows on the slopes of low hills, in sandy places, and in plains throughout Kazakhstan's territory. General distribution: China, Mongolia, and Central Asia [25][26][27].…”

Section: Introductionmentioning

confidence: 99%

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In Vitro and In Silico Cytotoxic and Antibacterial Activities of a Diterpene from Cousinia alata Schrenk

Zhanzhaxina

Suleimen

Metwaly

et al. 2021

Journal of Chemistry

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A biologically guided isolation of secondary metabolites from Cousinia alata Schrenk wild plant growing in Akmola region, Kazakhstan, led to the isolation of the bioactive diterpene grindelic acid (1). Six flavonoids were also isolated and identified as retusine (2), pachipodol (3), jaranol (4), penduletin (5), casticin (6), and 5, 7, 3′-trihydroxy-3, 4′-dimethoxyflavone (7). Penduletin (5) showed moderate cytotoxic activity assay. Grindelic acid exhibited promising cytotoxic activity against the Artemia salina nauplii and antibacterial activity against Staphylococcus aureus, Bacillus cereus, and Salmonella enteritidis. The presence of the essential pharmacophoric features of histone deacetylase (HDAC) inhibitors in the structure of grindelic acid encouraged us to run a molecular docking study against the HDAC enzyme to understand its mechanism of action on a molecular level. Grindelic acid showed a binding mode of interaction similar to that of the cocrystallized ligand and exhibited good binding affinity against HDAC with the binding free energy of −18.70 kcal/mol. The structures of isolated compounds were determined by MS, 1D, and 2D NMR spectroscopy methods. Compounds (1–7) were isolated for the first time from Cousinia genus.

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“…is plant grows on the slopes of low hills, in sandy places, and in plains throughout Kazakhstan's territory. General distribution: China, Mongolia, and Central Asia [25][26][27].…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, the cytotoxic effect of C. verbascifolia Bunge against OVCAR-3 and HT-29 cancer cells was reported [30]. Also, cytotoxicity of C. alata Schrenk essential oil was determined using the brine shrimp assay [27]. On the other hand, the antimicrobial properties of different Cousinia species have been proved [31,32].…”

Section: Introductionmentioning

confidence: 99%

In Vitro and In Silico Cytotoxic and Antibacterial Activities of a Diterpene from Cousinia alata Schrenk

Zhanzhaxina

Suleimen

Metwaly

et al. 2021

Journal of Chemistry

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“…Since the oldest historical records, nature granted humans their primary needs including treatments, food, as well as cosmetical products [ 1 , 2 ]. Modern science relates the biological activities of natural products to the presence of various sorts of secondary metabolites such as hydrocarbons [ 3 , 4 , 5 ], isochromenes [ 6 ], α-pyrones [ 7 , 8 ], diterpenes [ 9 ], sesquiterpenes [ 10 , 11 ], steroids [ 12 , 13 ], and saponins [ 14 , 15 , 16 ]. The computational (computer-based or in silico) chemistry approaches are efficient tools that have been employed to examine the biological activities of compounds virtually.…”

Section: Introductionmentioning

confidence: 99%

The Computational Preventive Potential of the Rare Flavonoid, Patuletin, Isolated from Tagetes patula, against SARS-CoV-2

Metwaly

Alsfouk

Saleh

et al. 2022

Plants

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The rare flavonoid, patuletin, was isolated from the flowers of Tagetes patula growing in Egypt. The rarity of the isolated compound inspired us to scrutinize its preventive effect against COVID-19 utilizing a multi-step computational approach. Firstly, a structural similarity study was carried out against nine ligands of nine SARS-CoV-2 proteins. The results showed a large structural similarity between patuletin and F86, the ligand of SARS-CoV-2 RNA-dependent RNA polymerase (RdRp). Then, a 3D-Flexible alignment study of patuletin and F86 verified the proposed similarity. To determine the binding opportunity, patuletin was docked against the RdRp showing a correct binding inside its active pocket with an energy of −20 kcal/mol that was comparable to that of F86 (−23 kcal/mol). Following, several MD simulations as well as MM-PBSA studies authenticated the accurate binding of patuletin in the RdRp via the correct dynamic and energetic behaviors over 100 ns. Additionally, in silico ADMET studies showed the general safety and drug-likeness of patuletin.

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“…We continued our research in the field of studying the component composition of essential oils and their biological activity of plants of Kazakhstan [1][2][3][4][5][6][7][8][9][10] and selected Tragopogon orientalis L. as the object.…”

Section: Introductionmentioning

confidence: 99%

The Component Composition of the Tragopogon Orientalis Volatile Constituents and Its Biological Activity

Suleimen

Sissengaliyeva

Ishmuratova

et al. 2019

JCPRM

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The purpose of this study is the chemical investigation of the composition of Tragopogon orientalis volatile constituents (VC) and studying of its biological activity. This article presents the results of research on the study of the chemical composition of species Tragopogon, as well as data of antiradical and cytotoxic activity. To study the dried and crushed aboveground part of the plant (leaves, flowers and stems) was taken. The raw material was collected in the flowering phase, growing in Northern Kazakstan. The VC was isolated from the plant of Tragopogon orientalis by hydrodistillation method on the Clevenger type apparatus. The chemical composition of the VC was determined by GC/MS. The cytotoxic activity of the VC was determined by the survival rate of sea shrimp Artemia salina. VC of T. orientalis in all studied concentrations (1–10 mg ml-1) exhibit acute lethal toxicity - all larvae die. Antiradical activity was determined by the method of colorimetry of free radicals (DPPH). The experimental results showed that the VC of T. orientalis at all tested concentrations (0.1–1.0 mg ml-1) exhibit low antiradical activity compared with the butylhydroxyanisole standard drug.

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Constituent Composition and Biological Activity of Essential Oil from Cousinia alata

Cited by 4 publications

References 4 publications

In Vitro and In Silico Cytotoxic and Antibacterial Activities of a Diterpene from Cousinia alata Schrenk

In Vitro and In Silico Cytotoxic and Antibacterial Activities of a Diterpene from Cousinia alata Schrenk

The Computational Preventive Potential of the Rare Flavonoid, Patuletin, Isolated from Tagetes patula, against SARS-CoV-2

The Component Composition of the Tragopogon Orientalis Volatile Constituents and Its Biological Activity

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