Constituent composition of the essential oils from some species of the genus <i>Saussurea</i> DC

Avdeeva, E. Yu.; Reshetov, Yaroslav; Domrachev, D. V.; Gulina, E. I.; Кривощеков, С. В.; Shurupova, Margarita; Brazovskii, Konstantin; Белоусов, Михаил Валерьевич

doi:10.1080/14786419.2020.1795655

Cited by 5 publications

(4 citation statements)

References 16 publications

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“…Saussurea costus is an herb used in many traditional medicine systems to treat asthma, inflammatory diseases, ulcers, and stomach problems [ 25 , 26 ]. Furthermore, several laboratory and animal model studies have demonstrated that Saussurea costus shows anti-inflammatory, anti-trypanosomal, potent anticancer, antibacterial, antifungal, and antiviral activity, confirming its tradition of use in various forms of medicine [ 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 ].…”

Section: Introductionmentioning

confidence: 88%

Phytochemical Discrimination, Biological Activity and Molecular Docking of Water-Soluble Inhibitors from Saussurea costus Herb against Main Protease of SARS-CoV-2

et al. 2022

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Siddha medicine is one of the oldest medical systems in the world and is believed to have originated more than 10,000 years ago and is prevalent across ancient Tamil land. It is undeniable that inhibitor preferences rise with increasing solubility in water due to the considerations pertaining to the bioavailability and the ease of which unabsorbed residues can be disposed of. In this study, we showed the phytochemical discrimination of Saussurea costus extracted with water at room temperature as a green extraction procedure. A total of 48 compounds were identified using gas chromatography-mass spectrometry (GC-MS). The fatty acids had a high phytochemical abundance at 73.8%, followed by tannins at 8.2%, carbohydrates at 6.9%, terpenoids at 4.3%, carboxylic acids at 2.5%, hydrocarbons at 2.4%, phenolic compounds at 0.2%, and sterols at 1.5%. Of these compounds, 22 were docked on the active side and on the catalytic dyad of His41 and Cys145 of the main protease of SARS-CoV-2 (Mpro). Eight active inhibitors were carbohydrates, five were fatty acids, three were terpenoids, two were carboxylic acids, one was a tannin, one was a phenolic compound, and one was a sterol. The best inhibitors were 4,8,13-Cyclotetradecatriene-1,3-diol, 1,5,9-trimethyl-12-(1-methylethyl), Andrographolide, and delta.4-Androstene-3.beta.,17.beta.-diol, with a binding affinity that ranged from −6.1 kcal/mol to −6.5 kcal/mol. The inhibitory effect of Saussurea costus of SARS-CoV-2 entry into the cell was studied using a pseudovirus with Spike proteins from the D614G variant and the VOC variants Gamma and Delta. Based on the viral cycle of SARS-CoV-2, our results suggest that the Saussurea costus aqueous extract has no virucidal effect and inhibits the virus in the events after cell entry. Furthermore, the biological activity of the aqueous extract was investigated against HSV-1 virus and two bacterial strains, namely Staphylococcus aureus ATCC BAA 1026 and Escherichia coli ATCC 9637. According to this study, an enormous number of water-soluble inhibitors were identified from Saussurea costus against the Mpro, and this is unprecedented as far as we know.

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Section: Introductionmentioning

confidence: 88%

Phytochemical Discrimination, Biological Activity and Molecular Docking of Water-Soluble Inhibitors from Saussurea costus Herb against Main Protease of SARS-CoV-2

et al. 2022

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“…The genus Saussurea DC (family Asteraceae) is represented by about 500 species, which are widespread in Eurasia and North America and have long been used in folk medicine in the form of single- and multi-component herbal preparations. More than 200 compounds have been isolated and identified from Saussurea genus members, including phenylpropanoids, sesquiterpenoids, flavonoids, phytosterols, triterpenoids, lignans, coumarins, ceramides, and polysaccharides [ 1 , 2 , 3 ]. Extracts from Saussurea plants have been reported to exhibit anti-inflammatory, antioxidant, anti-cancer, anti-arthritic, and circulatory effects [ 4 , 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Immunomodulatory Activity of Polysaccharides Isolated from Saussurea salicifolia L. and Saussurea frolovii Ledeb

Schepetkin,

Danilets,

Ligacheva

et al. 2023

Molecules

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The genus Saussurea has been used in the preparation of therapies for a number of medical problems, yet not much is known about the therapeutic high-molecular-weight compounds present in extracts from these plants. Since polysaccharides are important in immune modulation, we investigated the chemical composition and immunomodulatory activity of Saussurea salicifolia L. and Saussurea frolovii Ledeb polysaccharides. Water-soluble polysaccharides from the aerial parts of these plants were extracted using water at pHs of 2 and 6 and subsequently precipitated in ethanol to obtain fractions SSP2 and SSP6 from S. salicifolia and fractions SSF2 and SSF6 from S. frolovii. The molecular weights of fractions SSP2, SSP6, SFP2, and SFP6 were estimated to be 143.7, 113.2, 75.3, and 64.3 kDa, respectively. The polysaccharides from S. frolovii contained xylose (67.1–71.7%) and glucose (28.3–32.9%), whereas the polysaccharides from S. frolovii contained xylose (63.1–76.7%), glucose (11.8–19.2%), galactose (4.7–8.3%), and rhamnose (6.8–9.4%). Fractions SSP2, SSP6, and SFP2 stimulated nitric oxide (NO) production by murine macrophages, and NO production induced by SSP2, SSP6, and SFP2 was not inhibited by polymyxin B treatment of the fractions, whereaspolymyxin B treatment diminished the effects of SFP6, suggesting that SFP6 could contain lipopolysaccharide (LPS). The LPS-free fractions SSP2, SSP6, and SFP2 had potent immunomodulatory activity, induced NO production, and activated transcription factors NF-κB/AP-1 in human monocytic THP-1 cells and cytokine production by human MonoMac-6 monocytic cells, including interleukin (IL)-1α, IL-1β, IL-6, granulocyte macrophage colony-stimulating factor (GM-CSF), interferon-γ, monocyte chemotactic protein 1 (MCP-1), and tumor necrosis factor (TNF). These data suggest that at least part of the beneficial therapeutic effects reported for water extracts of the Saussurea species are due to the modulation of leukocyte functions by polysaccharides.

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“…(Asteraceae) have antimicrobial, anti-parasitic and anti-inflammatory activity attributed to the sesquiterpene lactones, [3][4][5][6] which biogenesis is similar to the oxygen-containing sesquiterpenoids. [3] The essential oil from Saussurea is widely used in traditional Chinese and Indian medicine as a single drug or in combination with other naturally occurring substances. [3,5] Saussurea lappa Clarke, known as Kuth root or costus, belongs to family Asteraceae (Compositae).…”

Section: Introductionmentioning

confidence: 99%

“…[3] The essential oil from Saussurea is widely used in traditional Chinese and Indian medicine as a single drug or in combination with other naturally occurring substances. [3,5] Saussurea lappa Clarke, known as Kuth root or costus, belongs to family Asteraceae (Compositae). [7] Oil from the roots used in traditional medicine and perfumes.…”

Section: Introductionmentioning

confidence: 99%

Secondary Metabolites Generated from Saussurea lappa and Ligusticum sinensis Essential Oils by Microwave‐Assisted Hydrodistillation: in Silico Molecular Docking and in Vitro Antibacterial Efficacy

Abd El‐Razek,

Saleh,

Abdel‐Halim

et al. 2023

Chemistry & Biodiversity

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In the current study, both the essential oil composition and biological activity of Saussurea lappa and Ligusticum sinensis were investigated by means of microwave‐assisted hydrodistillation (MAHD) and characterized by Gas chromatography/mass spectrometry (GC/MS), whereas the antimicrobial efficiency of MAHD essential oils was examined against four pathogens: Staphylococcus aureus, Escherichia coli, Aspergillus niger, and Candida albicans responsible for microbial infections. The goal was to spot synergy and a favorable method that gives essential oils to possibly use as alternatives to common antimicrobial agents for the treatment of bacterial infections using a microdilution assay. S. lappa's 21 compounds were characterized by MAHD extraction. Sesquiterpene lactones (39.7 % MAHD) represented the major components, followed by sesquiterpene dialdehyde (25.50 % MAHD), while L. sinensis's 14 compounds were identified by MAHD extraction. Tetrahydroisobenzofurans (72.94 % MAHD) was the predominant compound class. S. lappa essential oil collection showed the strongest antimicrobial activity with MIC values of 16 μg/ml against all pathogens tested, while L. sinensis showed strong antibacterial activity and moderate antifungal activity with MIC values of 32 μg/ml and 500 μg/ml, respectively. The principal components of both oils, (velleral, eremanthin and neocnidilide), were docked into the bacterial histidine kinase (HK) and the fungal heat shock protein 90 (Hsp90).

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Constituent composition of the essential oils from some species of the genus Saussurea DC

Cited by 5 publications

References 16 publications

Phytochemical Discrimination, Biological Activity and Molecular Docking of Water-Soluble Inhibitors from Saussurea costus Herb against Main Protease of SARS-CoV-2

Phytochemical Discrimination, Biological Activity and Molecular Docking of Water-Soluble Inhibitors from Saussurea costus Herb against Main Protease of SARS-CoV-2

Immunomodulatory Activity of Polysaccharides Isolated from Saussurea salicifolia L. and Saussurea frolovii Ledeb

Secondary Metabolites Generated from Saussurea lappa and Ligusticum sinensis Essential Oils by Microwave‐Assisted Hydrodistillation: in Silico Molecular Docking and in Vitro Antibacterial Efficacy

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