Constituents from oak bark (Quercus robur L.) inhibit degranulation and allergic mediator release from basophils and mast cells in vitro

Lorenz, Peter; Heinrich, M; Garcia-Käufer, Manuel; Grunewald, Franziska; Messerschmidt, Silke; Herrick, Anja; Gruber, Kim; Beckmann, Christiane; Knoedler, Matthias; Huber, Roman; Steinborn, Carmen; Stintzing, Florian C.; Gründemann, Carsten

doi:10.1016/j.jep.2016.10.027

Cited by 22 publications

(11 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Table 1 shows the main constituents of pine bark, where the compounds of the peaks 11, 12, 15, 16, 25, 36, 40, 41, and The polyphenolic profiles of Q. sideroxyla shown in Table 2 includes procyanidin dimer of catechin/epicatechin compounds (peaks 6, 10, 12, and 13) which is, by far, the dominant polyphenols in bark extract from this species, also reported in previous studies (Rosales et al, 2012). Other compounds present in the extract also compared with previously reported literature, resulted in the tentative identification of constituents such as Quercetin 3-O-glucoside and t-caftaric acid ([M-H] -463 and 311 respectively; Pardo-García et al, 2014), Ellagic acid-rhamnoside ([M-H] -447; Santos et al, 2013) gallic acid hexoside ([M-H] -331; Lorenz et al, 2016), taxifolin ([M-H] -303; Rosales et al, 2017). Other unknown compounds reported in barks detected in both extracts are also included ([M-H] -293; Mämmelä et al, 2000).…”

Section: Resultssupporting

confidence: 78%

Actividad citotóxica in vitro de los extractos de Pinus durangensis Martinez y Quercus sideroxyla Bonpl.

Arreola

2022

BIOTECNIA

View full text Add to dashboard Cite

En la actualidad, los compuestos bioactivos de las plantas representan un gran potencial para descubrir un fármaco novedoso que pueda actuar en el tratamiento del cáncer. Se ha informado que diferentes especies de pino y roble poseen actividades citotóxicas contra varias líneas celulares cancerosas. En el presente estudio, se evaluo el perfil fenólico y las actividades citotóxicas de extractos crudos y orgánicos de la corteza de P. durangensis y Q. sideroxyla. Algunos compuestos, como los dímeros de taxifolina y procianidina, fueron identificados en extractos de ambas especies mediante ESI-MS. La actividad citotóxica se realizó en MDA-MB-231 (cáncer de mama), HeLa (cáncer de cuello uterino), MCF-10A (células no tumorales de mama) y HSF-1184 (células de fibroblastos de piel humana) mediante ensayo MTT. Todos los extractos mostraron un efecto citotóxico dependiente de la dosis contra las líneas celulares cancerosas y poca o ninguna actividad contra las no tumorales. Los resultados proporcionan información importante sobre la actividad citotóxica de extractos de corteza de P. durangensis y Q. sideroxyla.

show abstract

Section: Resultssupporting

confidence: 78%

Actividad citotóxica in vitro de los extractos de Pinus durangensis Martinez y Quercus sideroxyla Bonpl.

Arreola

2022

BIOTECNIA

View full text Add to dashboard Cite

show abstract

“…For red grade pomace peels it was shown that drying temperatures at 60 °C showed no significant effects on the stability of polyphenols and their antioxidant activity [57] . Especially condensed polyphenolic tannins are found in tree and shrub barks, which play an eminent role in protecting the plant [58] . Dichloromethane and aqueous fermented extracts did not show any inhibitory effect at the measured concentrations.…”

Section: Resultsmentioning

confidence: 90%

“…Column chromatography was performed to fractionate tannins [62,58] . For this purpose, 25 g of Sephadex TM LH‐20 (GE Healthcare Bio‐Sciences AB, Uppsala, Sweden) was swollen in 200 mL water overnight and filled into a chromatography column.…”

Section: Methodsmentioning

confidence: 99%

Evaluation of Geum urbanum L. Extracts with Respect to Their Antimicrobial Potential

Bunse

Mailänder

Lorenz

et al. 2022

Chemistry & Biodiversity

Self Cite

View full text Add to dashboard Cite

Preparations derived from roots and rhizomes of Geum urbanum L. are traditionally used for the treatment of ulcers and irritations of mucous membranes of the mouth, stomach, and intestinal tract. In complementary medicine, fermentation is one of the methods applied to recover plant extracts used for the production of such pharmaceutical preparations. The present study was performed to characterize the secondary metabolites and to evaluate the antimicrobial potential of different G. urbanum root and rhizome extracts. For this purpose, individual metabolites of fresh and fermented G. urbanum root and rhizome extracts were analyzed by HPLC‐DAD‐MSn and GC/MS. Among others, rare ellagitannin‐sulfates could be characterized by LC/MSn. In addition, the antibacterial activity of various extracts of fresh and dried G. urbanum roots and rhizomes against Staphylococcus aureus (ATCC 6538) and Cutibacterium acnes (CP033842.1; FDAARGOS 503 chromosome) were assessed and compared to that of G. rivale. Furthermore, low‐ and high‐molecular tannins were fractionated by column chromatography, demonstrating the latter to exhibit highest antibacterial activity.

show abstract

“…Although allergens in tannins have not been identified to date, the tannin-induced allergenic response is associated with inhibition of IL-8, IL-6, and TNF-α secretion from stimulated human mast cells. 49 The resulting color intensity that can be achieved by some plant colorants, such as pure henna, is time dependent. 47 Some darkening substances in proprietary formulas, such as lemon oil, vinegar, eucalyptus oil, or clove oil, may be added along with PPD to shorten the time of application.…”

Section: Hair Dye-induced Toxicities and Adverse Health Effectsmentioning

confidence: 99%

Hair Dye Ingredients and Potential Health Risks from Exposure to Hair Dyeing

Michailidou

Gahlon

Zeng

2022

Chem. Res. Toxicol.

View full text Add to dashboard Cite

Given the worldwide popularity of hair dyeing, there is an urgent need to understand the toxicities and risks associated with exposure to chemicals found in hair dye formulations. Hair dyes are categorized as oxidative and nonoxidative in terms of their chemical composition and ingredients. For several decades, the expert panel’s Cosmetic Ingredient Review (CIR) has assessed the safety of many of the chemicals used in hair dyes; however, a comprehensive review of hair dye ingredients and the risk of exposure to hair dyeing has not been documented. Herein, we review the safety of the various chemicals in oxidative and nonoxidative hair dyes, toxicities associated with hair dyeing, and the carcinogenic risks related to hair dyeing. While many compounds are considered safe for users at the concentrations in hair dyes, there are conflicting data about a large number of hair dye formulations. The CIR expert panel has ratified a number of coloring ingredients for hair dyes and banned a series of chemicals as carcinogenic to animals and unsafe for this application. The use of these chemicals as raw materials for producing hair dyes may result in the synthesis of other contaminants with potential toxicities and increased risk of carcinogenesis. It is an open question whether personal or occupational hair dyeing increases the risk of cancer; however, in specific subpopulations, a positive association between hair dye use and cancer occurrence has been reported. To address this question, a better understanding of the chemical and mechanistic basis of the reported toxicities of hair dye mixtures and individual hair dye ingredients is needed. It is anticipated that in-depth chemical and systems toxicology studies harnessing modern and emerging techniques can shed light on this public health concern in the future.

show abstract

Constituents from oak bark (Quercus robur L.) inhibit degranulation and allergic mediator release from basophils and mast cells in vitro

Cited by 22 publications

References 39 publications

Actividad citotóxica in vitro de los extractos de Pinus durangensis Martinez y Quercus sideroxyla Bonpl.

Actividad citotóxica in vitro de los extractos de Pinus durangensis Martinez y Quercus sideroxyla Bonpl.

Evaluation of Geum urbanum L. Extracts with Respect to Their Antimicrobial Potential

Hair Dye Ingredients and Potential Health Risks from Exposure to Hair Dyeing

Contact Info

Product

Resources

About