Constituents from ripe figs of Ficus vallis-choudae Delile (Moraceae) with antiplasmodial activity

Chouna, Hardo Suzy Donfack; Dize, Darline; Kagho, Donald Ulrich Kenou; Bankeu, Jean Jules Kezetas; Fongang, Yannick Stéphane Fotsing; Tali, Mariscal Brice Tchatat; Ponou, Beaudelaire Kemvoufo; Bitchagno, Gabin Thierry M.; Awantu, Angelbert Fusi; Tapondjou, Léon Azefack; Lenta, Bruno Ndjakou; Boyom, Fabrice Fekam; Sewald, Norbert; Ngouela, Silvère

doi:10.1007/s00436-022-07540-5

Cited by 2 publications

(3 citation statements)

References 27 publications

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“…1 H NMR (400 MHz, DMSO- d 6 ) δ 13.07 (s, 1H, –OH), 9.64 (s, 1H, –OH), 8.38 (s, 1H, –OCH=C–), 7.37 (d, J = 8.6 Hz, 2H, –Ph), 6.82 (d, J = 8.6 Hz, 2H, –Ph), 6.64 (d, J = 10.0 Hz, 1H, –CH=CHC(CH 3 ) 2 O–), 6.23 (s, 1H, –Ph), 5.75 (d, J = 10.0 Hz, 1H, –CH=CHC(CH 3 ) 2 O–), 1.42 (s, 6H, –CH 3 ); 13 C NMR (150 MHz, DMSO- d 6 ) δ 181.1 (C=O), 162.0, 159.3, 158.1, 154.6, 152.1, 130.8 (2 × C), 128.7, 123.1, 121.5, 115.6 (2 × C), 114.4, 105.9, 101.2, 99.9, 78.7, 28.3 (2 × C). The spectroscopic data correspond to reported values [ 41 ].…”

Section: Methodssupporting

confidence: 83%

Total Syntheses and Antibacterial Studies of Natural Isoflavones: Scandenone, Osajin, and 6,8-Diprenylgenistein

Dong,

Che,

Zhu

et al. 2024

Molecules

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Isoflavones are a class of natural products that exhibit a wide range of interesting biological properties, including antioxidant, hepatoprotective, antimicrobial, and anti-inflammatory activities. Scandenone (1), osajin (2), and 6,8-diprenylgenistein (3) are natural prenylated isoflavones that share the same polyphenol framework. In this research, the key intermediate 15 was used for the synthesis of the natural isoflavones 1–3, establishing a stereoselective synthetic method for both linear and angular pyran isoflavones. The antibacterial activities of 1–3 were also evaluated, and all of them displayed good antibacterial activity against Gram-positive bacteria. Among them, 2 was the most potent one against MRSA, with a MIC value of 2 μg/mL, and the SEM assay indicated that the bacterial cell membranes of both MRSA and E. faecalis could be disrupted by 2. These findings suggest that this type of isoflavone could serve as a lead for the development of novel antibacterial agents for the treatment of Gram-positive bacterial infections.

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Section: Methodssupporting

confidence: 83%

Total Syntheses and Antibacterial Studies of Natural Isoflavones: Scandenone, Osajin, and 6,8-Diprenylgenistein

Dong,

Che,

Zhu

et al. 2024

Molecules

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“…Over the past decades, the medicinal properties of the genus Ficus have been extensively investigated through both ethnobotanical field surveys and pharmacological studies [37]. Many Ficus species have been used in traditional medicine in the treatment of a variety of ailments and diseases such as convulsive disorder [7], wound healing [30], gonorrhea [11], tuberculosis [3], diabetes [12], diarrheal infections [18], dysentery [36], malaria [8] and HIV [17]. These plants possess antioxidant [29], anti-diabetes and anti-hyper-glycemic [27], antibacterial [28], antifungal [43], antiviral [13], anti-protozoal [8], anticancer [25], cytotoxic [32], anti-ulcer [16], antiinflammatory [26], anti-diarrhea [18], hepatoprotective [34], muco-protective and gastroprotective activities [35].…”

Section: Introductionmentioning

confidence: 99%

“…Many Ficus species have been used in traditional medicine in the treatment of a variety of ailments and diseases such as convulsive disorder [7], wound healing [30], gonorrhea [11], tuberculosis [3], diabetes [12], diarrheal infections [18], dysentery [36], malaria [8] and HIV [17]. These plants possess antioxidant [29], anti-diabetes and anti-hyper-glycemic [27], antibacterial [28], antifungal [43], antiviral [13], anti-protozoal [8], anticancer [25], cytotoxic [32], anti-ulcer [16], antiinflammatory [26], anti-diarrhea [18], hepatoprotective [34], muco-protective and gastroprotective activities [35]. These plants to be rich sources of flavonoids, lignans, terpenoids, alkaloids, coumarins steroids, and ceramides [3,10].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Antimicrobial Activity of Ethanolic Extract Derived From Leaves of Ficus Cyathistipula Warb. (Moraceae)

Tkachenko¹,

Kurhaluk²,

Buyun³

et al. 2023

BHT

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Purpose: We continue our investigations regarding assessing the antibacterial and antioxidant properties of extracts derived from the leaves of various plants belonging to the Ficus genus. In the current study, we aimed to assess the antibacterial properties of ethanolic extract prepared from leaves of Ficus cyathistipula Warb. against some Gram-positive and Gram-negative bacteria to evaluate the possible use of this plant in the prevention and treatment of bacterial infections caused by these bacteria. Methodology. The leaves of F. cyathistipula were sampled at M.M. Gryshko National Botanic Garden (NBG, Kyiv, Ukraine) and the Botanic Garden of Ivan Franko National University in Lviv (Lviv, Ukraine). Freshly collected leaves were washed, weighed, and homogenized in 96% ethanol (in the proportion of 1:9, w/w) at room temperature. The extract was then filtered and investigated for its antimicrobial activity. The testing of the antibacterial activity of the plant extract was carried out in vitro by the Kirby-Bauer disc diffusion technique. Gram-negative bacteria, Pseudomonas aeruginosa (Schroeter) Migula (ATCC®27853™), Escherichia coli (Migula) Castellani and Chalmers (ATCC®35218™), and Escherichia coli (Migula) Castellani and Chalmers (ATCC®25922™), as well as Gram-positive bacteria Staphylococcus aureus subsp. aureus strain (ATCC®25923™), Staphylococcus aureus subsp. aureus strain (ATCC®29213™) and methicillin-resistant Staphylococcus aureus (NEQAS 3679™), as well as the fungus Candida albicans locally isolated, were used as test organisms. Zone diameters were determined and averaged. The following zone diameter criteria were used to assign susceptibility or resistance of bacteria to the phytochemicals tested: Susceptible ≥ 15 mm, Intermediate = 10–15 mm, and Resistant ≤ 10 mm. Scientific novelty. The ethanolic extract derived from the leaves of F. cyathistipula exhibited varying inhibitory activities against all the test strains. More sensitive for this extract was C. albicans strain. S. aureus subsp. aureus strain (ATCC® 25923™), S. aureus subsp. aureus strain (ATCC® 29213™), methicillin-resistant S. aureus (NEQAS 3679™), P. aeruginosa (Schroeter) Migula (ATCC® 27853™), E. coli (Migula) Castellani and Chalmers (ATCC® 25922™), and E. coli (Migula) Castellani and Chalmers (ATCC® 35218™) strains were more resistant to F. cyathistipula extract. The results are encouraging enough to pursue bioactivity-guided fractionation of this extract and structure elucidation of the active phytoconstituents from the F. cyathistipula extract as a possible anti-bacterial agent. Conclusions. S. aureus and C. albicans appeared to be more sensitive to the F. cyathistipula extract. The antibacterial activity may be associated with the presence of secondary metabolites. The results of this study provide baseline information on F. cyathistipula potential validity in the treatment of fungus-induced and bacterial infections, caused by Candida albicans and Staphylococcus aureus.

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Constituents from ripe figs of Ficus vallis-choudae Delile (Moraceae) with antiplasmodial activity

Cited by 2 publications

References 27 publications

Total Syntheses and Antibacterial Studies of Natural Isoflavones: Scandenone, Osajin, and 6,8-Diprenylgenistein

Total Syntheses and Antibacterial Studies of Natural Isoflavones: Scandenone, Osajin, and 6,8-Diprenylgenistein

Evaluation of Antimicrobial Activity of Ethanolic Extract Derived From Leaves of Ficus Cyathistipula Warb. (Moraceae)

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