Constituents from the leaves of Crataegus davisii Browicz

Sözer, Ulaş

doi:10.3797/scipharm.2006.74.203

Cited by 17 publications

(14 citation statements)

References 3 publications

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“…The flavonoid content of the leaves was found as 1.09 % and the antioxidant activity expressed by IC 50 value was found as 1.57 mg/ml by DPPH method (Sozer et al, 2006).…”

Section: Hplc-dad-esi (+)Ms Analysis Of Crataegus Monogyna and Cornusmentioning

confidence: 99%

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Comparative HPLC-DAD-ESI(+)MS Fingerprint and Quantification of Phenolic and Flavonoid Composition of Aqueous Leaf Extracts of Cornus mas and Crataegus monogyna, in Relation to Their Cardiotonic Potential

Badalica-Petrescu

Drăgan

Ranga

et al. 2014

Not Bot Hort Agrobot Cluj

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Our study aimed to compare the phenolic and flavonoid composition of two medicinal plants from the wild flora of Romania, traditionally known to be efficient in preventing cardiotoxicity: Cornus mas and Crataegus monogyna. As most previous studies have focused on fruits, our investigations aimed to fingerprint and quantify the two classes of compounds in aqueous leaf extracts, based on HPLC-DAD-ESI(+)MS analysis. The specific HPLC-DAD fingerprint was coupled with UV spectra at 280 and 340 nm to discriminate between three subclasses of compounds: two hydroxycinnamic acids and a flavonoid glycoside. While the C. monogyna extract contained more than 98% vitexin isomers (2'-and 4'-O-rhamnoside), the C. mas extract was very complex, containing a mixture of phenolic derivatives and flavonoid glycosides. The spectral patterns of C. mas, combined with the molecular mass and specific fragmentations allowed the identification of epi-catechin, coumaric and caffeic acids and quercetin derivatives. Based on LC-MS peak area and parallel calibrations with gallic acid and rutin, the mean concentration for flavonoids in C. mas was 13 mg/100 ml, while aprox. 65 mg/100 ml in C. monogyna extracts. Using the Folin method, the total phenol content was 105 mg/100 ml in C. mas and around three times less in the C. monogyna extract, while the antioxidant activity was increased only 1.5-1.7 times in C. mas extract compared to C. monogyna. These findings suggest a higher stability and potential of flavonoids to act as antioxidants in hydrophilic environment.

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“…The flavonoid content of the leaves was found as 1.09 % and the antioxidant activity expressed by IC 50 value was found as 1.57 mg/ml by DPPH method (Sozer et al, 2006).…”

Section: Hplc-dad-esi (+)Ms Analysis Of Crataegus Monogyna and Cornusmentioning

confidence: 99%

“…Few data about the composition of leaves were reported, e.g. five flavonoids were found in Crataegus davisii (hyperoside, vitexin 2''-rhamnoside, vitexin 4'-rhamnoside, rutin, quercetin) together with chlorogenic acid and crataequinone B (Sozer et al, 2006). Belkhir et al against cardiotoxicity in rats (Eshaghi et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Comparative HPLC-DAD-ESI(+)MS Fingerprint and Quantification of Phenolic and Flavonoid Composition of Aqueous Leaf Extracts of Cornus mas and Crataegus monogyna, in Relation to Their Cardiotonic Potential

Badalica-Petrescu

Drăgan

Ranga

et al. 2014

Not Bot Hort Agrobot Cluj

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“…Dried flowers, leaves and fruits are mainly used for mild to moderately severe heart failure and coronary heart diseases. Oligomeric procyanidins and (-)-epicatechin as well as flavonoids are known as the main active constituents (Svedström et al, 2002;Sözer et al, 2006). C. laevigata flowers and leaves methanolic water extract led to the isolation of procyanidins.…”

Section: Flavonoidsmentioning

confidence: 99%

“…Extract A was chromatographed first by vacuum liquid chromatography (VLC) on silica gel with Petroleum ether-CHCl 3 -MeOH mixtures. (Sözer et al, 2006). Apigenin, hesperetin, eriodictyol, luteolin, quercetin, luteolin-7-O-glucoside, hyperoside, vitexin, vitexin-4'-O-rhamnoside were isolated from Crataegus microphylla C. Koch.…”

Section: Flavonoidsmentioning

confidence: 99%

Column Chromatography for Terpenoids and Flavonoids

Çitoğlu¹,

Açıkara²

2012

Chromatography and Its Applications

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“…These flavones are a series of compounds whose aglycones are apigenin or luteolin. These flavones include apigenin (1), luteolin (2), orientin (3), iso-orientin (4), vitexin (5), vitexin rhamnoside (6), isovitexin (7), hyperoside (8), pinnatifinoside A-D, I (9-13), 3′′′,4′′′-di-O-acetyl-2′′-O-α-rhamnosylvitexin (14), schaftoside (15), isoschaftoside (16), neoschaftoside (17), neoisoschaftoside (18), cratenacin (19), acetylvitexin (20). Additionally, crataequinone B (21) was isolated from the leaves of C. pinnatifida [17] (Figure 1).…”

Section: Flavonesmentioning

confidence: 99%

Crataegus pinnatifida: Chemical Constituents, Pharmacology, and Potential Applications

et al. 2014

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Abstract:Crataegus pinnatifida (Hawthorn) is widely distributed in China and has a long history of use as a traditional medicine. The fruit of C. pinnatifida has been used for the treatment of cardiodynia, hernia, dyspepsia, postpartum blood stasis, and hemafecia and thus increasing interest in this plant has emerged in recent years. Between 1966 and 2013, numerous articles have been published on the chemical constituents, pharmacology or pharmacologic effects and toxicology of C. pinnatifida. To review the pharmacologic advances and to discuss the potential perspective for future investigation, we have summarized the main literature findings of these publications. So far, over 150 compounds including flavonoids, triterpenoids, steroids, monoterpenoids, sesquiterpenoids, lignans, hydroxycinnamic acids, organic acids and nitrogen-containing compounds have been isolated and identified from C. pinnatifida. It has been found that these constituents and extracts of C. pinnatifida have broad pharmacological effects with low toxicity on, for example, the cardiovascular, digestive, and endocrine systems, and pathogenic microorganisms, supporting the view that C. pinnatifida has favorable therapeutic effects. Thus, although C. pinnatifida has already been widely used as pharmacological therapy, due to its various active compounds, further research is warranted to develop new drugs.

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Constituents from the leaves of Crataegus davisii Browicz

Cited by 17 publications

References 3 publications

Comparative HPLC-DAD-ESI(+)MS Fingerprint and Quantification of Phenolic and Flavonoid Composition of Aqueous Leaf Extracts of <i>Cornus mas<i> and <i>Crataegus monogyna</i>, in Relation to Their Cardiotonic Potential

Comparative HPLC-DAD-ESI(+)MS Fingerprint and Quantification of Phenolic and Flavonoid Composition of Aqueous Leaf Extracts of <i>Cornus mas<i> and <i>Crataegus monogyna</i>, in Relation to Their Cardiotonic Potential

Column Chromatography for Terpenoids and Flavonoids

Crataegus pinnatifida: Chemical Constituents, Pharmacology, and Potential Applications

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