Constituents of Breadfruit tree (<i>Treculia africana</i>) Leaves, Stem and Root Barks

Aboaba, Sherifat A.; Ekundayo, Olusegun; Omikorede, Oluwole

doi:10.1080/0972060x.2007.10643541

Cited by 8 publications

(2 citation statements)

References 4 publications

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“…[29][30][31][32] Further studies have elucidated ivorenosides A, B and C as triterpene saponins in T. ivorensis and, 6,9-dihydro-megastigmane-3-one, 4-hydroxybenzoic acid, α-pinene, myrtenal, limonene, camphene and n-hexanoic acid in T. Africana. 33,34 These natural product constituents could be investigated further for their anti-plasmodial effects.…”

Section: Discussionmentioning

confidence: 99%

Anti-plasmodial, Cytotoxic and Antioxidant Activities of Selected Ghanaian Medicinal Plants

Appiah–Opong

Agyemang

Dotse

et al. 2022

J Evid Based Complementary Altern Med

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Malaria affects about half of the world's population. The sub-Saharan African region is the most affected. Plant natural products have been a major source of antimalarial drugs; the first (quinine) and present (artemisinin) antimalarials are of natural product origin. Some secondary metabolites demonstrate adjuvant antioxidant effects and selective activity. The focus of this study was to investigate the anti-plasmodial activity, cytotoxicities and antioxidant properties of eight (8) Ghanaian medicinal plants. The anti-plasmodial activity was determined using the SYBR green assay and the tetrazolium-based colorimetric assay (MTT) was employed to assess cytotoxicity of extracts to human RBCs and HL-60 cells. Antioxidant potential of plant extracts was evaluated using Folin-Ciocalteu and superoxide dismutase assays. Phytochemical contstituents of the plant extracts were also assessed. All the extracts demonstrated anti-plasmodial activities at concentrations <50 μg/ml. Parkia clappertoniana and Terminalia ivorensis elicited the strongest anti-plasmodial activities with 50% inhibitory concentrations (IC50) of 1.13 μg/ml and 0.95 μg/ml, respectively. This is the first report on anti-plasmodial activities of Baphia nitida, Tabernaemontana crassa and Treculia Africana. T. Africana showed moderate anti-plasmodial activity with IC50 value of 6.62 µg/mL. Extracts of P. clappertoniana, T. Africana and T. ivorensis (0.4 mg/mL) showed >50% antioxidant effect (SOD). The extracts were not cytotoxicity towards RBCs at the concentration tested (200 μg/ml) but were weakly cytotoxic to HL-60 cell. Selectivity indices of most of the extracts were greater than 10. Our results suggest that most of the plant extracts have strong anti-plasmodial activity and antioxidant activity which warrants further investigations.

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Section: Discussionmentioning

confidence: 99%

Anti-plasmodial, Cytotoxic and Antioxidant Activities of Selected Ghanaian Medicinal Plants

Appiah–Opong

Agyemang

Dotse

et al. 2022

J Evid Based Complementary Altern Med

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“…In this study, the leaves of T. tetraptera from Nigeria were analyzed for their essential oil composition, cytoxicity and antimicrobial activity. This study is part of an extensive research program aimed at the characterization of the volatile constituents of Nigerian medicinal plants and herbs [9].…”

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confidence: 99%

Essential Oil Composition, Antibacterial Activity and Toxicity of the Leaves of Tetrapleura Tetraptera (Schum. & Thonn.) Taubert from Nigeria

Aboaba

Ogunwande

Walker

et al. 2009

Natural Product Communications

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The composition of the essential oil of the leaves of Tetrapleura tetraptera (Schum. & Thonn.) Taubert. from Nigeria were analyzed by GC/MS. Forty-one compounds representing 89.5% of the essential oil were characterized. The essential oil was dominated by 1,8-cineole (19.4%), 6,10,14-trimethyl-2-pentadecanone (13.6%), phytol (9.1%), α-pinene (8.1%) and geranylacetone (6.7%). The oil exhibited moderate toxicity in the brine shrimp lethality assay (117.5 µg/mL), and displayed weak antibacterial activity against Bacillus subtilis.

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Applications of Gas Chromatography–Mass Spectrometry (GC–MS): An Examination of Selected African Cases

2012

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Constituents of Breadfruit tree (Treculia africana) Leaves, Stem and Root Barks

Cited by 8 publications

References 4 publications

Anti-plasmodial, Cytotoxic and Antioxidant Activities of Selected Ghanaian Medicinal Plants

Anti-plasmodial, Cytotoxic and Antioxidant Activities of Selected Ghanaian Medicinal Plants

Essential Oil Composition, Antibacterial Activity and Toxicity of the Leaves of Tetrapleura Tetraptera (Schum. & Thonn.) Taubert from Nigeria

Applications of Gas Chromatography–Mass Spectrometry (GC–MS): An Examination of Selected African Cases

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