Constituents of Cannabis sativa L. IV: Stability of Cannabinoids in Stored Plant Material

Analysis of cannabinoids by liquid chromatography— Thermospray mass spectrometry and liquid chromatography— Tandem mass spectrometry

“…Investigation of the extract of the heated resin showed that A9-THCA had been fully decarboxylated. Ag-THCA is converted into A9-THC which partially degraded into CBN [13,14]. On the LC-MS traces, peak 1A (A9-THCA) disappeared, the intensity of peak 3B (CBN) increased ten-fold (compared with the intensity of peak 3A in Figure 1 Figure 2).…”

Polymeric systems for amorphous Δ9-tetrahydrocannabinol produced by a hot-melt method. Part I: Chemical and thermal stability during processing

“…However, it was determined that this degradant could not completely account for the amount of THC lost, which is consistent with other studies. 4,6 Those studies were conducted on the THC stability in plant extracts or the herb itself. Examination of the HPLC chromatograms confirmed the presence of other peaks eluting before CBN and THC suggesting the relative polar nature of these decomposition products.…”

“…THC is a brown, oily resin that is viscous and sticky at ambient conditions and hardens upon refrigeration, suggesting that the glass transition temperature (T g ) is below 258C, necessitating its storage at relatively low temperatures for stability purposes. Indeed, T g of the drug was well below room temperature as determined by van Drooge et al 2 The stability of THC has been a subject of numerous investigations [3][4][5][6][7][8][9][10][11][12] and it has been reported that the drug is susceptible to decomposition by light, heat, and oxidation. Storage leads to a cumulative decrease in THC content through its oxidation to cannabinol (CBN), which is the most widely recognized thermo-oxidative degradation product of THC.…”

Determination of the relative percentage distribution of THCA and Δ9-THC in herbal cannabis seized in Austria – Impact of different storage temperatures on stability

“…On the European drugs market the two distinct products "marijuana" (herbal cannabis) and "hashish" (cannabis resin) are mainly traded. According to the European Drug Report 2014, 73.6 million (21.7%) adults (15-64) used cannabis in their lifetime, while 18.1 million (5.3%) adults (15-64) and 14.6 million (11.2%) young adults (15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34) consumed cannabis in the last year. The prevalence of the misuse of these herbal products is pronounced due to the fact that over 80% of the seizures in Europe are cannabis [3].…”