Constituents of Chimaphila japonica and Their Diuretic Activity

Yu, Yue; Hu, Deri; Liu, Jinze; Wu, Chenghao; Sun, Yuhong; Lang, Mingyue; Han, Xuan; Kang, Dongzhou; Min, Jun Zhe; Cui, Hong; Zheng, Mingshan

doi:10.3390/molecules29051092

Cited by 3 publications

(2 citation statements)

References 20 publications

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“…Diuretics are important for treating many diseases, including hypertension, kidney disorders, and acute heart failure [ 26 , 27 , 28 , 29 ]. However, because chemically synthesized diuretics used in clinical practice have potential side effects [ 30 , 31 , 32 ], there is a need for natural diuretics.…”

Section: Discussionmentioning

confidence: 99%

Assessment of the Diuretic Properties of Rice Bean Accessions Using a Mouse Model and Identification of Active Polyphenolic Compounds

Gong,

Zhang,

Yao

et al. 2024

Nutrients

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Rice bean [Vigna umbellata (Thunb.) Ohwi and Ohashi], an annual legume in the genus Vigna, is a promising crop suitable for cultivation in a changing climate to ensure food security. It is also a medicinal plant widely used in traditional Chinese medicine; however, little is known about the medicinal compounds in rice bean. In this study, we assessed the diuretic effect of rice bean extracts on mice as well as its relationship with the contents of eight secondary metabolites in seeds. Mice gavaged with rice bean extracts from yellow and black seeds had higher urinary output (5.44–5.47 g) and water intake (5.8–6.3 g) values than mice gavaged with rice bean extracts from red seeds. Correlation analyses revealed significant negative correlations between urine output and gallic acid (R = −0.70) and genistein (R = −0.75) concentrations, suggesting that these two polyphenols negatively regulate diuresis. There were no obvious relationships between mice diuresis-related indices (urine output, water intake, and weight loss) and rutin or catechin contents, although the concentrations of both of these polyphenols in rice bean seeds were higher than the concentrations of the other six secondary metabolites. Our study findings may be useful for future research on the diuretic effects of rice bean, but they should be confirmed on the basis of systematic medical trials.

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Section: Discussionmentioning

confidence: 99%

Assessment of the Diuretic Properties of Rice Bean Accessions Using a Mouse Model and Identification of Active Polyphenolic Compounds

Gong,

Zhang,

Yao

et al. 2024

Nutrients

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“…In the current drug discovery module, molecular docking is the most widely used bioinformatics tool in academia and the pharmaceutical sector, where natural resources are the most alternative drug source and choice for most research work to use on a complementary, alternative, and repurposing basis (Swain et al, 2022a andSahoo et al, 2022a and. Researchers have implemented several similar types of computational-based approaches to assess the diuretic potency of natural products derived from different natural sources at a preliminary level, prior to expensive experimental studies (Islam et al, 2022;Yang et al, 2022;Yu et al, 2024). Generally, various constituents in crude extracts synergistically show multiple biological activities, but not all compounds are responsible for all diseases.…”

Section: Pharmacokinetics and Overall Drug Likeness Predictionmentioning

confidence: 99%

Alcoholic Extracts of Eleusine indica as Alternative Diuretic Regimens: A Computational Based Investigation

Sahu,

Sahoo,

Pattnaik

et al. 2024

IJERR

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Diuretics are widely used in current clinical practice to increase urine production and excrete electrolytes, particularly sodium and chloride ions, without affecting the absorption of protein, vitamins, carbohydrates, or amino acids. From the time of mercury chloride and organomercurials in ancient times to now (with sulphonamides, thiazides, and furosemide), a lot has changed in the field of diuretics. However, long-term use of such synthetic diuretic agents in clinical practice produces several adverse effects, such as blurred vision, loss of appetite, stomach upset, carcinomas, headaches, phototoxic impact, weakness., etc., as has been observed from recent investigations. Natural regimens can serve as potential alternatives to using nontoxic diuretic agents. Based on long-term ethnomedicinal and biological activity records, we have explored the diuretic effects of the widely known perennial herb in Pacific Islands regions and a weed in agricultural fields, Eleusine indica (L) Gaertn phytoconstituents, on a computation platform. Therefore, we conducted a bio-assay-guided crude extraction using ethanol, followed by further gas chromatography-mass spectrometry (GC-MS) analyses of the extracted crude extracts. Further selected nine constituents (EI_1 to EI_9) carried out the diuretic potency against three putative target enzymes (ACE, KCNJ1, and SLC12A1) along with three standard drugs (VU590, TSM, and FSM) through molecular docking studies using AutoDock 4.2 software. We also predict physicochemical profiles, or Lipinski Rule of Five profiles, toxicity, and pharmacokinetics using various bioinformatics and cheminformatics tools. Based on the overall investigation, it was revealed that EI_6 [Z, Z-6,28-Heptatriacontadien-2-one] was the most potential, nontoxic, and drug-able candidate. In summary, advanced computational tools play a crucial role in selecting potential preclinical candidates within limited resources to accelerate the current drug discovery process.

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Chemical constituents of Ulmus pumila L. and their chemotaxonomic significance

Hu,

Liu,

et al. 2024

Biochemical Systematics and Ecology

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Constituents of Chimaphila japonica and Their Diuretic Activity

Cited by 3 publications

References 20 publications

Assessment of the Diuretic Properties of Rice Bean Accessions Using a Mouse Model and Identification of Active Polyphenolic Compounds

Assessment of the Diuretic Properties of Rice Bean Accessions Using a Mouse Model and Identification of Active Polyphenolic Compounds

Alcoholic Extracts of Eleusine indica as Alternative Diuretic Regimens: A Computational Based Investigation

Chemical constituents of Ulmus pumila L. and their chemotaxonomic significance

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