Constituents of French Marigold (<i>Tagetes patula</i> L.) Flowers Protect Jurkat T‐Cells against Oxidative Stress

Chkhikvishvili, I; Sanikidze, Т; Gogia, N; Enukidze, M; Machavariani, M; Kipiani, Nana; Vinokur, Yakov; Rodov, Victor

doi:10.1155/2016/4216285

Cited by 34 publications

(23 citation statements)

References 35 publications

(44 reference statements)

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“…T. patula essential oil from Aragua state, Venezuela has been reported to contained βterthienyl (43.1%), pentatriacontane (23.9%) and 2-hexyl-1-decanol (7.8%) as major components (Romagnoli, 2005). Piperitone (33.77%), trans-β-ocimene (14.83%) and terpinolene (13.87%) were reported as major constituents in the essential oil from aerial parts of T. patula grown in Venezuela (Rondon, 2006 of leaf and flower essential oil of T. patula from Gurugram Haryana, India showed that limonene (12.9%) and piperitone (11.9%) as predominant compounds in leaf essential oils and trans-sesquisabinene hydrate (12.5%), pcymen-8-ol (11.0%) and piperitone (10.6%) in the flower essential oil (Chkhikvishvili, 2016). From Northwest Iran, hydrodistilled volatile seed oil composition of commonly growing ornamental T. patula was analyzed for its constituents by GC/MS.…”

Section: Resultsmentioning

confidence: 99%

“…Commercially, Tagetes essential oil is produced from T. patula and T. minuta in some countries such as France, Australia and Kenya and also produced in India to a small extent (Adams, 2017). It is commercially cultivated in India as a floriculture crop (Bhattacharyya, 2010;Chkhikvishvili, 2016). The plant is herbaceous, branched, glabrous, annual and bushy.…”

Section: Introductionmentioning

confidence: 99%

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Chemical composition of the essential oils of Tagetes patula L. during different phenological stages

Kafaltiya¹,

Lohani²,

Haider³

et al. 2019

JCHPS

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The present study aims to investigate the detailed essential oil profiling of Tagetes patula L. at different stages of plant growth i.e. pre-flowering stage, full flowering and seed settings stages. The essential oils were obtained through hydro-distillation and analyzed by GC and GC/MS for the identification of their chemical constituents. The essential oil yield (%) from fresh aerial parts of T. patula were 0.06%, 0.06% and 0.08% (v/w) at pre flowering, full flowering and seed setting stages, respectively. A total of 38 components were identified, representing 89.65%, 91.94% and 90.84% in pre flowering, full flowering and seed setting stages, respectively. Chromatographic analysis (GC and GC/MS) has shown that all the oils of T. patula were dominated by monoterpene hydrocarbons (39.81-45.08%) followed by oxygenated monoterpenes (27.57-31.66%), sesquiterpene hydrocarbons (7.72-10.52%), oxygenated sesquiterpenes (6.63-7.57%) while diterpenes (1.39-1.68%) and oxygenated diterpenes (0.93-1.55%) were found in the lesser amounts. The major constituents in the oils were z-(β)-ocimene (12.76-20.29%), α-terpinolene (11.01-14.79%), piperitenone (6.46-11.96%), limonene (6.62-7.57%) and propanedinitrile dicyclohexyl (5.17-5.85%). Maximum content of z-(β)-ocimene (20.29%) was found at full flowering stage, while α-terpinolene (14.79%) and piperitenone (11.96%) at pre-flowering stage. The study concluded that however the oils were qualitatively similar but differed quantitatively during different growth stages.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Chemical composition of the essential oils of Tagetes patula L. during different phenological stages

Kafaltiya¹,

Lohani²,

Haider³

et al. 2019

JCHPS

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“…The high anti-ischemic and antihypoxic activity of the studied extracts may be related to their rich chemical composition. So in extracts from Tagetes patula L., patuletin, patuletrin, luteolin, sesquiterpene lactones with an extensive spectrum of pharmacological activity are found includes antioxidant, anti-inflammatory, anti-cancer and cytoprotective properties (Chkhikvishvili et al, 2016). In the extract obtained from Gaillardia pulchella Foug, the main biologic active substances are represented by vicenin-2, vitexin, luteolin, apigeninone and 6-methoxylyl-tetolin, exhibiting antioxidant, anti-inflammatory and hepatoprotective activity (Moharram et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Antihypoxic and anti-ischemic properties of the North Caucasus flora plant extract

Pozdnyakov¹,

Pozdnyakova²,

Adzhiahmetova³

et al. 2019

Bol Latinoam Caribe Plant Med Aromat

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Nowdays it is established that ischemic brain damage like ischemic stroke is one of the leading cause of death and disability in the population that assumes relevance development of anti-ischemic drugs. The work studied the anti-hypoxic and anti-ischemic effect of 7 plant extracts. Antihypoxic activity was assessed on models of hypobaric, hypercapnic, histotoxic, hematotoxic hypoxia. Anti-ischemic activity of test-extracts was studied on the focal cerebral ischemia model. Administration of Tagetes patula, Gaillardia pulchella, Sorbaria sorbifolia, Grossularia reclinata, Ribes nigrum, Rubus caesius and Lysimachia punctata extracts contributed to the necrosis zone reduction by 56.6% (p<0.05); 37.3% (p<0.05); 73.2% (p<0.05); 49.4% (p<0.05); 42.5% (p<0.05); 85.5% (p<0.05); 44.2% (p<0.05) and also restored aerobic metabolism in brain tissue. Test -objects increased of the animal lifespan under hypoxia conditions. Based on the data obtained, it is assumed that further studies of North Caucasus flora plant extracts as cerebro-protective agents are promising.Resumen: Hoy en día, se ha establecido que el daño cerebral isquémico, como el accidente cerebrovascular isquémico, es una de las principales causas de muerte y discapacidad en la población lo cual hace relevante el desarrollo fármacos antiisquémicos. En este trabajo se estudió el efecto antihipóxico y antiisquémico de siete extractos de plantas. La actividad antihipóxica se evaluó en modelos de hipoxia hipocrática, hipercápnica, histotóxica y hematotóxica. La actividad antiisquémica de los extractos de prueba se estudió en el modelo de isquemia cerebral focal. La administración de los extractos de Tagetes patula; Gaillardia pulchella; Sorbaria sorbifolia; Grossularia reclinata; Ribes nigrum; Rubus caesius y Lysimachia punctata contribuyeron a la reducción de la zona de necrosis en un 56,6% (p<0,05); 37,3% (p<0,05); 73,2% (p<0,05); 49,4% (p<0,05); 42,5% (p<0,05); 85,5% (p<0,05); 44.2% (p<0.05), respectivamente, además, de restaurar el metabolismo aeróbico en el tejido cerebral. Comparado con el control, se observó un aumento en el tiempo de sobrevida del animal en condiciones de hipoxia. Sobre la base de los interesantes datos obtenidos, se sugiere estudios adicionales de extractos de plantas de la flora del Cáucaso Norte como agentes protectores del cerebro. Palabras clave: Isquemia cerebral; Extracto de plantas; Cáucaso norteRecibido |

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“…Quercetin, 6-hydroxykaempferol (50 μg/mL) obtained from Tagetes erecta L. exhibited significant anticancer activity against A549 and HEPG2 cells whereas, protocatechuic acid and quercetagetin were effective against A549 cells [75]. Crude extracts containing different flavonoid fractions and the flavonoid fraction rich in quercetin and quercetagetin possessed maximum cytoprotective activity and patuletin at high dose can exert cytotoxic effect on Jurkart cells [76]. Chemical nature of the compound and its concentration is important in deciding its cytoprotective and cytotoxic activity.…”

Section: Anti Cancer/anti Tumormentioning

confidence: 99%

Marigold: From Mandap to Medicine and from Ornamentation to Remediation

Mir¹,

Ahanger²,

Agarwal³

2019

AJPS

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Importance of medicinal plants to health care has been great and herbal preparations are being produced at industrial scale particularly in developing countries. The plant products obtained have a long history of use in therapeutics, aromatherapy and food depending on the chemical constituents and their bioactivity. In the recent past, marigolds have received a great attention in scientific research, because of their multiple use and also the information available about their phytochemistry and bioactivity. Tagetes species commonly known as marigold is native to Mexico, being used for medicinal and ornamental purposes. The plant is useful due to its unique phytoconstituents for a range of diseases and disorders and is reportedly effective against piles, kidney troubles, muscular pain, ulcers and wound healing and the flowers are helpful in fever, stomach and liver complaints and also in eye diseases. In India, marigold is also extensively used on religious and social occasions such as in the beautification of mandaps and pooja places; offerings at temples; marriage decorations and landscape planning due to variable size and colour of its flower. Present review is an effort to bring together the different strategies developed for the growth and cultivation of marigold, its ecophysiological and remediation relevance under a variety of environmental conditions and possible allelopathic potential. It includes reports on pharmacological aspects like antibacterial, antifungal, larvicidal, hepatoprotective, insecticidal, mosquitocidal, nematicidal, wound healing, antioxidant, anticancer and antidiabetic properties/activity of Tagetes.

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Constituents of French Marigold (Tagetes patula L.) Flowers Protect Jurkat T‐Cells against Oxidative Stress

Cited by 34 publications

References 35 publications

Chemical composition of the essential oils of Tagetes patula L. during different phenological stages

Chemical composition of the essential oils of Tagetes patula L. during different phenological stages

Antihypoxic and anti-ischemic properties of the North Caucasus flora plant extract

Marigold: From Mandap to Medicine and from Ornamentation to Remediation

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