Constituents of glandular trichomes of Tithonia diversifolia: Relationships to herbivory and antifeedant activity

Ambrósio, Sérgio Ricardo; Oki, Yumi; Heleno, Vladimir Constantino Gomes; Chaves, J.; Nascimento, Paulo Gustavo Barboni Dantas; Lichston, Juliana Espada; Constantino, Maurício Gomes; Varanda, Elenice Mouro; Costa, Fernando B. Da

doi:10.1016/j.phytochem.2008.03.019

Cited by 99 publications

(91 citation statements)

References 31 publications

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“…Fouad et al (2014) reported that extracts of Tithonia diversifolia Hemsl. at 1 % w/w discouraged egg laying and larval mortality of S. cerealella; potentiality of this plant extract is due to the presence of sesquiterpenes, lactones (Ambrosio et al 2008). In another recent work, Ileke (2014) reported that powders and extracts of Capsicum frutescens L., Cymbopogon citratus DC.…”

Section: B Bioactivity Of Plant Extracts On Immature Stagesmentioning

confidence: 98%

Potentiality of botanical agents for the management of post harvest insects of maize: a review

et al. 2016

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Natural products derived from plants are emerging as potent biorational alternatives to synthetic insecticides for the integrated management of post harvest insects of maize. In this paper, effectiveness of botanicals including plant extracts, essential oils, their isolated pure compounds, plant based nano formulations and their mode of action against storage insects have been reviewed with special reference to maize. Plant based insecticides found to be the most promising means of controlling storage insects of maize in an eco friendly and sustainable manner. This article also throws light on the commercialization of botanicals, their limitations, challenges and future trends of storage insect management.

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Section: B Bioactivity Of Plant Extracts On Immature Stagesmentioning

confidence: 98%

Potentiality of botanical agents for the management of post harvest insects of maize: a review

et al. 2016

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“…The material was identified by F. B. Da Costa, and a voucher specimen was deposited in the SPFR Herbarium, Department of Biology, Ribeirão Preto, SP, University of São Paulo, under the number FBC #126. Air-dried entire leaves were rinsed for a few seconds with dichloromethane, for dissolution of the glandular trichomes [2], thereby yielding 5 g of a yellow crude extract after filtration with common filter paper and solvent evaporation under reduced pressure. The dry residue was re-suspended in MeOH/H 2 O (7:3, v/v) and extracted with n-hexane followed by dichloromethane.…”

Section: Isolation Of Tagitinin C (1)mentioning

confidence: 99%

“…7736) by vacuum liquid chromatography [9] using increasing amounts of ethyl acetate in n-hexane, thereby yielding nine fractions of 250 ml each. The tagitinin C-rich fractions (3 and 4) (1.5 g, confirmed by infrared spectroscopy, TLC, and reversed-phase HPLC analysis, as well as comparison with an authentic sample [2]) were purified by centrifugal chromatography (silica gel PF 254 , Merck, Brazil, cat. no.…”

Section: Isolation Of Tagitinin C (1)mentioning

confidence: 99%

“…A. Gray, Asteraceae) [2]. It shows cytotoxic [19], anti-inflammatory [33], and antifeedant activities [2], and thus is a promising compound for further research into its mechanisms of action in different targets.…”

Section: Introductionmentioning

confidence: 99%

“…Gray, Asteraceae) [2]. It shows cytotoxic [19], anti-inflammatory [33], and antifeedant activities [2], and thus is a promising compound for further research into its mechanisms of action in different targets. T. diversifolia, the source of 1, is used in folk medicine in many countries [8,14] and has anti-inflammatory and antimalarial properties [8].…”

Section: Introductionmentioning

confidence: 99%

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Microbial transformation of the sesquiterpene lactone tagitinin C by the fungus Aspergillus terreus

Rocha

Pupo

Antonucci³

et al. 2012

Journal of Industrial Microbiology and Biotechnology

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The biotransformation of the sesquiterpene lactone tagitinin C by the fungus Aspergillus terreus MT 5.3 yielded a rare derivative that was elucidated by spectrometric methods. The fungus led to the formation of a different product through an unusual epoxidation reaction between C4 and C5, formation of a C3,C10 ether bridge, and a methoxylation of the C1 of tagitinin C. The chemical structure of the product, namely 1b-methoxy-3a-hydroxy-3,10b-4,5a-diepoxy-8b-isobutyroyloxygermacr-11(13)-en6a,12-olide, is the same as that of a derivative that was recently isolated from the flowers of a Brazilian population of Mexican sunflower (Tithonia diversifolia), which is the source of the substrate tagitinin C. The in vitro cytotoxic activity of the substrate and the biotransformed product were evaluated in HL-60 cells using an MTT assay, and both compounds were found to be cytotoxic. We show that soil fungi may be useful in the biotransformation of sesquiterpene lactones, thereby leading to unusual changes in their chemical structures that may preserve or alter their biological activities, and may also mimic plant biosynthetic pathways for production of secondary metabolites.

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Ethnobotany, Chemistry, and Biological Activities of the Genus Tithonia (Asteraceae)

Chagas‐Paula

Oliveira

Rocha

et al. 2012

Chemistry & Biodiversity

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The genus Tithonia is an important source of diverse natural products, particularly sesquiterpene lactones, diterpenes, and flavonoids. The collected information in this review attempts to summarize the recent developments in the ethnobotany, biological activities, and secondary metabolite chemistry of this genus. More than 100 structures of natural products from Tithonia are reported in this review. The species that has been most investigated in this genus is T. diversifolia, from which ca. 150 compounds were isolated. Biological studies are described to evaluate the anti-inflammatory, analgesic, antimalarial, antiviral, antidiabetic, antidiarrhoeal, antimicrobial, antispasmodic, vasorelaxant, cancer-chemopreventive, cytotoxic, toxicological, bioinsecticide, and repellent activities. A few of these studies have been carried out with isolated compounds from Tithonia species, but the majority has been conducted with different extracts. The relationship between the biological activity and the toxicity of compounds isolated from the plants of this genus as well as T. diversifolia extracts still remains unclear, and mechanisms of action remain to be determined.

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Constituents of glandular trichomes of Tithonia diversifolia: Relationships to herbivory and antifeedant activity

Cited by 99 publications

References 31 publications

Potentiality of botanical agents for the management of post harvest insects of maize: a review

Potentiality of botanical agents for the management of post harvest insects of maize: a review

Microbial transformation of the sesquiterpene lactone tagitinin C by the fungus Aspergillus terreus

Ethnobotany, Chemistry, and Biological Activities of the Genus Tithonia (Asteraceae)

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