Constituents of Holothuroidea. Part 15. Isolation of Ante‐iso Type Regioisomer on Long Chain Base Moiety of Glucocerebroside from the Sea Cucumber Holothuria leucospilota.

Abstract

Lipids U 0750Constituents of Holothuroidea. Part 15. Isolation of Ante-iso Type Regioisomer on Long Chain Base Moiety of Glucocerebroside from the Sea Cucumber Holothuria leucospilota. -The β-D-glucopyranosyl ceramide (I) is isolated with the help of RP(C30)-HPLC from a mixture of regioisomeric glucocerebrosides obtained from a sea cucumber species. -(YAMADA, K.; WADA, N.; ONAKA, H.; MATSUBARA, R.; ISOBE, R.; INAGAKI, M.; HIGUCHI*, R.; Chem. Pharm. Bull. 53 (2005) 7, 788-791; Fac. Pharm. Sci., Kyushu Univ., Fukuoka 812, Japan; Eng.) -H. Haber 50-190

Glycolipids from Marine Invertebrates

“…The Japanese sea cucumber Holothuria pervicax was shown to contain GSLs, the ceramides of which were of the sphingosine type or phytosphingosine type bases that were iso-and anteiso-branched (Yamada et al, 2002). The new sphingosine-type glucocerebroside HLC-2-A with an anteiso-type side chain of the long-chain base moiety was isolated from the whole bodies of the Japanese sea cucumber Holothuria leucospilota (Yamada et al, 2005a). This compound has been isolated from its parent glucocerebroside molecular species HLC-2 composed of iso and anteiso isomers.…”