Constituents of Huberantha jenkinsii and Their Biological Activities

San, Htoo Tint; Chaowasku, Tanawat; Mekboonsonglarp, Wanwimon; Rodsiri, Ratchanee; Sritularak, Boonchoo; Buraphaka, Hathairat; Putalun, Waraporn; Likhitwitayawuid, Kittisak

doi:10.3390/molecules25153533

Cited by 5 publications

(3 citation statements)

References 28 publications

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“…The α -glucosidase enzyme inhibition assay was carried out according to the method in our previous report [ 27 ]. The inhibitory activity was determined by measuring the p -nitrophenol, a yellow color substance that can be monitored at 405 nm, released from p -nitrophenyl-α-D-glucopyranoside ( p NPG) by the α -glucosidase enzyme.…”

Section: Methodsmentioning

confidence: 99%

Four Novel Phenanthrene Derivatives with α-Glucosidase Inhibitory Activity from Gastrochilus bellinus

et al. 2021

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Four new phenanthrene derivatives, gastrobellinols A-D (1–4), were isolated from the methanolic extract of Gastrochilus bellinus (Rchb.f.) Kuntze, along with eleven known phenolic compounds including agrostophyllin (5), agrostophyllidin (6), coniferyl aldehyde (7), 4-hydroxybenzaldehyde (8), agrostophyllone (9), gigantol (10), 4-(methoxylmethyl)phenol (11), syringaldehyde (12), 1-(4′-hydroxybenzyl)-imbricartin (13), 6-methoxycoelonin (14), and imbricatin (15). Their structures were determined by spectroscopic methods. Each isolate was evaluated for α-glucosidase inhibitory activity. Compounds 1, 2, 3, 7, 9, 13, and 15 showed higher activity than the drug acarbose. Gastrobellinol C (3) exhibited the strongest α-glucosidase inhibition with an IC50 value of 45.92 μM. A kinetic study of 3 showed competitive inhibition on the α-glucosidase enzyme. This is the first report on the phytochemical constituents and α-glucosidase inhibitory activity of G. bellinus.

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Section: Methodsmentioning

confidence: 99%

Four Novel Phenanthrene Derivatives with α-Glucosidase Inhibitory Activity from Gastrochilus bellinus

et al. 2021

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“…TCT α-glucosidase inhibitory activity, IC 50 , was 0.42 µM in Tribulus terrestris Linn. and 0.6 µM in Huberantha jenkinsii [66]. One study showed that TCT extract from Tribulus terrestris induced extrinsic, as well as intrinsic, apoptosis pathways in cancer cells [67].…”

Section: Other Small Molecular Constituentsmentioning

confidence: 99%

A Frontier Review of Nutraceutical Chinese Yam

Khol,

Ma,

Lei

et al. 2024

Foods

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Yams are the edible subterranean rhizomes, or tubers, of plants from the genus Dioscorea. There are approximately 600 species of yam plants in the world, with more than 90 of these growing in East Asia. One particular species, Dioscorea opposita Thunb., is highly praised as “the Chinese yam”. This distinction arises from millennia of storied history, both as a nutritional food source and as a principal ingredient in traditional Chinese medicine. Among the many cultivars of Dioscorea opposita Thunb., Huai Shanyao has been widely regarded as the best. This review surveyed the historical background, physiochemical composition, applications as food and medicine, and research prospects for the Chinese yam. Modern science is finally beginning to confirm the remarkable health benefits of this yam plant, long-known to the Chinese people. Chinese yam promises anti-diabetic, anti-oxidative, anti-inflammatory, immunomodulatory, anti-hyperlipidemic, anti-hypertensive, anti-cancer, and combination treatment applications, both as a functional food and as medicine.

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“…7 In addition, in our previous work, it has been proved that NCT isolated from Chinese yam (Dioscorea opposita Thunb.) has excellent hypoglycemic activity against αglucosidase (IC50 = 0.40 μM) 8 and its inhibitory activity on αglucosidase was even better than that of drug acarbose, 9 which can be used as a candidate drug to reduce blood glucose. However, its poor water solubility and stability limit its bioavailability.…”

Section: ■ Introductionmentioning

confidence: 99%

Glucose-Triggered Release of trans-N-p-Coumaroyltyramine from Zeolitic Imidazolate Framework-8 (ZIF8) Modified with Dioscorea opposita Thunb Polysaccharide

et al. 2023

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A Dioscorea opposita Thunb polysaccharide (DOP)modified ZIF8 material was developed in this study, which can be used as a "smart" glucose-responsive carrier to control the slow release of drugs. The 3-aminophenylboronic acid (APBA) functionalized carboxylated long-chain polymer poly(ethylene glycol) (PEG) segments, which were first modified on the surface of ZIF8 nanoparticles with a hydrogen bond and then chemically cross-linked with DOP through a borate ester bond, leading to the drugs loaded on ZIF8 being "closed" in PBS but being "open" via taking off the DOP coating in high concentrations of glucose; thus, leakage can be prevented in the drug loaded and a glucose-triggered release can effectively result. Moreover, the materials showed good biocompatibility and the released trans-N-p-coumaroyltyramine (NCT) could work synergistically with the DOP to improve insulin resistance and promote glucose consumption in insulinresistant HepG2 cells.

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Constituents of Huberantha jenkinsii and Their Biological Activities

Cited by 5 publications

References 28 publications

Four Novel Phenanthrene Derivatives with α-Glucosidase Inhibitory Activity from Gastrochilus bellinus

Four Novel Phenanthrene Derivatives with α-Glucosidase Inhibitory Activity from Gastrochilus bellinus

A Frontier Review of Nutraceutical Chinese Yam

Glucose-Triggered Release of trans-N-p-Coumaroyltyramine from Zeolitic Imidazolate Framework-8 (ZIF8) Modified with Dioscorea opposita Thunb Polysaccharide

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