Constituents of the Cultivated Mulberry Tree

Abstract

From extracts of root bark of the cultivated mulberry tree (a variety of Morus alba L.) three new isoprene-substituted flavanones, Kuwanon D, E and F were isolated. Their structures were shown to be I, II and III, respectively.

Effects ofMorus albaL. and Natural Products Including Morusin onIn VivoSecretion andIn VitroProduction of Airway MUC5AC Mucin

“…Subfraction E27 was purified repeated silica gel CC (CHCl 3 :MeOH:H 2 O, 25:1:0.1 to 10:1:0.1) and LiChroprep RP 18 CC (MeOH:H 2 O, 2:3) to yield mulberofuran G (15.9 mg), and kuwanon E (43.7 mg). The physico-chemical data including 1 H NMR, 13 C NMR, and HSQC of these compounds were identical with those reported in the literature15,16,17,18.…”

Constituents of the Chinese Crude Drug „Sāng-Bái-Pí” (Morus Root Bark)

“…Comparison between 111 NMR spectra of lb and Ic indicates that acetylation of the tertiary hydroxyl group at C-2 position in lb caused a higher applied magnetic field shift of the proton at C-6' position as follows: lb 67.42 (C-6'-H); leo 7.16 (C-6'-H). A similar result was reported in the case of kuwanon D (IX) [8]. Comparison between the 1H NMR spectra of IX and its diacetate (IXa) indicates that the acetylation of the hydroxyl group at the C-2' position in IX caused a higher applied magnetic field shift of the proton at the C-2 position as follows: IX, 66.23 (C-2-H); IXa, 6 5.85 (C-2-H).…”

“…prene substituted 2-arylbenzofuran derivatives [4][5][6][7][8]. Recently, we reported the isolation from the root bark and structure determination of three new flavone derivatives having a hypotensive effect, kuwanon G (= albanin F = moracenin B, III) [9][10][11][12], kuwanon H (= albanin G = moracenin A, IV) [10,13,14], and moracenin D (V) [12,15] as well as a 2-arylbenzofuran derivative having a hypotensive effect, mu!berrofuran C (VI) [16].…”

“…The methylene group protons of the y,y-dimethylallyl group appeared to be nonequivalent, and suggested that the y ,-dimethylallyl group was located at the asymmetric centre [19]. The arrangements of substituents in both A and B rings are assumed by the 'H NMR spectrum as follows: a singlet signal at 6 5.77 (C-8-H) indicates that the A ring is unsubstituted at the C-6 or C-8 position [20] and a doublet signal at 66.41 (1H, J = 2Hz, C-3'-H), double doublet at 66.53 (1H, J = 2 and 8Hz, C-5'-H) and doublet at 67.35 (1H, J = 8Hz, C-6'-H) indicate that the B ring of I is substituted in the 2'-and the 4'position [4,5,8]. The mass spectrum of!…”

A new Diels–Alder type adduct and two new flavones from the stem bark ofMorus yunanensisKoidz

“…1 Previously, many novel phenolic compounds and Diels -Alder type adducts of dehydroprenylphenols and chalcone derivatives were isolated from the genus Morus. 2,3 Morus yunanensis Koidz is distributed in the southern part of China, especially in Yunnan Province.…”