Constituents of the Leaves ofMacarangatanarius

Abstract

From the leaves of Macaranga tanarius, three new constituents, tanarifuranonol (1), tanariflavanone C (2), and tanariflavanone D (3), together with seven known compounds, were isolated and identified. Substances obtained in this investigation were evaluated against a panel of bioassays.

Phytochemistry and pharmacology of the genus Macaranga: A review

“…The results indicated that compounds 26 to 28 and 10 indicated comparable radical scavenging properties with IC 50 values of 20 ± 1, 14 ± 1, 13 ± 2 and 15 ± 2 mM, respectively. These IC 50 values were higher than that of compound 25 and a standard (BHT) which showed IC 50 values of 33 ± 1 and 30 ± 1, respectively (Phormmart et al, 2005).…”

“…Previous investigation on the chemistry and pharmacology of this genus showed that its crude extracts and compounds displayed interesting bioactivity profiles, possessing various bioactivities including anticancer (Yoder et al, 2007;Zakaria et al, 2012), antioxidant (Phormmart et al, 2005;Matsunami et al, 2009), antmicrobial (Schutz et al, 1995;Lim et al, 2009), anti-inflammatory (Jang et al, 2002;Ngoumfo et al, 2008) and other different types of biological activities (Thanh et al, 2012;Zakaria et al, 2012). …”

“…tanarius is well known in Thai traditional medicine as an antipyretic and emetic agent (Phupattanapong and Wongprasert, 1987). Phytochemical work on the leaves of this species gave five flavonols (10, 25 to 28) that were tested for antioxidant activity with the DPPH stable radical (Phormmart et al, 2005). The results indicated that compounds 26 to 28 and 10 indicated comparable radical scavenging properties with IC 50 values of 20 ± 1, 14 ± 1, 13 ± 2 and 15 ± 2 mM, respectively.…”

“…A phytochemical review of literatures indicates the genus Macaranga to be a rich source of the isoprenylated, geranylated and farnesylated flavonoids (Schutz et al, 1995;Jang et al, 2002;Phormmart et al, 2005;Kawakami et al, 2008;Thanh et al, 2012) and stilbenes (Beutler et al, 1998;Yoder et al, 2007;Thanh et al, 2012). Furthermore, more classes of secondary metabolites like terpenes (Salah et al, 2003;Jang et al, 2004;Phormmart et al, 2005;Kawakami et al, 2008), tannins (Lin et al, 1990;Gunawan-Puteri and Kawabata, 2010;Ngoumfo et al, 2008), coumarins (Sutthivaiyakit et al, 2002;Darmawan et al, 2012) and other types of compounds (Ramaiah et al, 1979;Ngoumfo et al, 2008;Matsunami et al, 2009;Zakaria et al, 2010) are known to be isolated from different species of the genus Macaranga. Flavonoids and stilbenes are regarded as the major constituents and are most likely responsible for most of the activities found in the plants of this genus.…”

“…An increasing number of phytochemical studies are being carried out on plants belonging to the genus Macaranga due to their various traditional uses. Thus, the isolated natural products from this genus have been reported to display interesting biological activities including antitumor (Kaaden et al, 2001;Yoder et al, 2007;Zakaria et al, 2012), antioxidant (Sutthivaiyakit et al, 2002;Phormmart et al, 2005;Matsunami et al, 2009), antimicrobial (Salah et al, 2003;Lim et al, 2009) and anti-inflammatory (Jang, et al, 2002). This is a resourceful area of research as many species of Macaranga are used in traditional medicine as well as exhibits various pharmacological properties while their chemistry indicates varied chemical structures.…”