Constituents, Pharmacokinetics, and Pharmacology of Gegen-Qinlian Decoction

Lu, Jingze; Ye, Dan; Ma, Bing-Liang

doi:10.3389/fphar.2021.668418

Cited by 40 publications

(34 citation statements)

References 142 publications

(209 reference statements)

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“…lobata (Willd.) Maesen & S. M. Almeida ex Sanjappa & Predeep, Scutellaria baicalensis Georgi, Coptis chinensis Franch., and Glycyrrhiza glabra L.; is a classical, traditional Chinese botanical drug that has been used extensively in clinics in China for hundreds of years; and has definite effects in the treatment of NAFLD (Lu et al, 2021). Furthermore, GQD can block hepatic NLRP3, caspase-1, and ASC expression, further inhibiting NLRP3 inflammasome activation.…”

Section: Gegen Qinlian Decoctionmentioning

confidence: 99%

The NLRP3 Inflammasome in Non-Alcoholic Fatty Liver Disease and Steatohepatitis: Therapeutic Targets and Treatment

Wang

et al. 2022

Front. Pharmacol.

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Non-alcoholic fatty liver disease (NAFLD) is among the most prevalent primary liver diseases worldwide and can develop into various conditions, ranging from simple steatosis, through non-alcoholic steatohepatitis (NASH), to fibrosis, and eventually cirrhosis and hepatocellular carcinoma. Nevertheless, there is no effective treatment for NAFLD due to the complicated etiology. Recently, activation of the NLPR3 inflammasome has been demonstrated to be a contributing factor in the development of NAFLD, particularly as a modulator of progression from initial hepatic steatosis to NASH. NLRP3 inflammasome, as a caspase-1 activation platform, is critical for processing key pro-inflammatory cytokines and pyroptosis. Various stimuli involved in NAFLD can activate the NLRP3 inflammasome, depending on the diverse cellular stresses that they cause. NLRP3 inflammasome-related inhibitors and agents for NAFLD treatment have been tested and demonstrated positive effects in experimental models. Meanwhile, some drugs have been applied in clinical studies, supporting this therapeutic approach. In this review, we discuss the activation, biological functions, and treatment targeting the NLRP3 inflammasome in the context of NAFLD progression. Specifically, we focus on the different types of therapeutic agents that can inhibit the NLRP3 inflammasome and summarize their pharmacological effectiveness for NAFLD treatment.

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Section: Gegen Qinlian Decoctionmentioning

confidence: 99%

The NLRP3 Inflammasome in Non-Alcoholic Fatty Liver Disease and Steatohepatitis: Therapeutic Targets and Treatment

Wang

et al. 2022

Front. Pharmacol.

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“…Gegen Qinlian Decoction, containing Radix Puerariae , Radix Scutellariae , C. Rhizoma and Glycyrrhiza at a rate of 5:3:3:2 (w/w/w/w), is frequently used to treat UC by means of its anti-inflammatory and antioxidative properties and inhibition of the transcription of oncogenes ( Wei M. et al, 2020 ). It not only exerts antitumor effects when used alone, as described in a recent review ( Lu et al, 2021 ), but also improves clinical symptoms and reduces adverse events in combination with western medicines ( Fan Y. et al, 2019 ).…”

Section: Combination Therapymentioning

confidence: 99%

Current Advances in Coptidis Rhizoma for Gastrointestinal and Other Cancers

Chen

Liang

et al. 2022

Front. Pharmacol.

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Cancer is a serious disease with an increasing number of reported cases and high mortality worldwide. Gastrointestinal cancer defines a group of cancers in the digestive system, e.g., liver cancer, colorectal cancer, and gastric cancer. Coptidis Rhizoma (C. Rhizoma; Huanglian, in Chinese) is a classical Chinese medicinal botanical drug for the treatment of gastrointestinal disorders and has been shown to have a wide variety of pharmacological activity, including antifungal, antivirus, anticancer, antidiabetic, hypoglycemic, and cardioprotective effects. Recent studies on C. Rhizoma present significant progress on its anticancer effects and the corresponding mechanisms as well as its clinical applications. Herein, keywords related to C. Rhizoma, cancer, gastrointestinal cancer, and omics were searched in PubMed and the Web of Science databases, and more than three hundred recent publications were reviewed and discussed. C. Rhizoma extract along with its main components, berberine, palmatine, coptisine, magnoflorine, jatrorrhizine, epiberberine, oxyepiberberine, oxyberberine, dihydroberberine, columbamine, limonin, and derivatives, are reviewed. We describe novel and classic anticancer mechanisms from various perspectives of pharmacology, pharmaceutical chemistry, and pharmaceutics. Researchers have transformed the chemical structures and drug delivery systems of these components to obtain better efficacy and bioavailability of C. Rhizoma. Furthermore, C. Rhizoma in combination with other drugs and their clinical application are also summarized. Taken together, C. Rhizoma has broad prospects as a potential adjuvant candidate against cancers, making it reasonable to conduct additional preclinical studies and clinical trials in gastrointestinal cancer in the future.

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“…GQD consists of only 4 herbs (Radix Puerariae lobatae (Ge Gen), Radix Scutellariae (Huang Qin), Rhizoma coptidis (Huang Lian), and Radix Glycyrrhizae (Gan Cao)). GQD is traditionally and clinically used to treat both the “external and internal symptoms” of diarrhea with fever [ 44 ] and is known for its streamlined prescription. Third, in determining the duration of diarrhea heterogeneity, we have showed that the course of treatment was an influencing factor.…”

Section: Discussionmentioning

confidence: 99%

Efficacy and Safety of Gegen Qinlian Decoction for Pediatric Diarrhea: A Systematic Review and Meta-Analysis

Wang

Jiang

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Objective. To evaluate the clinical efficacy and safety of Gegen Qinlian decoction in the treatment of pediatric diarrhea. Methods. A search for relevant RCTs was performed from which a systematic review and meta-analysis was conducted. This meta-analysis was registered at INPLASY (reference number ID: INPLASY202180105). Results. (1) Eleven trials involving 1126 patients were included in the meta-analysis. (2) Two trials recorded the adverse events. (3) The meta-analysis showed that compared with the control group, the experimental group has a significantly shorter duration of diarrhea in children (MD = −18.64, 95% CI (−23.76, −13.52), P < 0.00001 ), duration of fever (MD = −19.43, 95% CI (−25.76, −13.11), P < 0.00001 ), duration of vomiting [MD = −22.51, 95% CI (−29.92, −15.09), P < 0.00001 ], duration of correcting dehydration (MD = −23.35, 95% CI (−35.48, −11.22), P = 0.0002 ), and the effective rate (OR = 4.64, 95% CI (3.12, 6.90), P < 0.00001 ). Conclusion. There were significant differences in the clinical efficacy in the treatment of pediatric diarrhea between the experimental and control groups. Thus, Gegen Qinlian decoction may have certain advantages in the treatment of pediatric diarrhea. In addition, we conclude the following: (1) the application of Gegen Qinlian decoction to treat this disease is recommended for >5 days. (2) We recommend conducting multicenter RCTs to avoid the impact of regional differences on the results. (3) We recommend using the unmodified Gegen Qinlian decoction, which may have better efficacy.

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Constituents, Pharmacokinetics, and Pharmacology of Gegen-Qinlian Decoction

Cited by 40 publications

References 142 publications

The NLRP3 Inflammasome in Non-Alcoholic Fatty Liver Disease and Steatohepatitis: Therapeutic Targets and Treatment

The NLRP3 Inflammasome in Non-Alcoholic Fatty Liver Disease and Steatohepatitis: Therapeutic Targets and Treatment

Current Advances in Coptidis Rhizoma for Gastrointestinal and Other Cancers

Efficacy and Safety of Gegen Qinlian Decoction for Pediatric Diarrhea: A Systematic Review and Meta-Analysis

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