Constitutive activation of signal transducer and activator of transcription 3 in epithelial ovarian carcinoma

Abstract

Overexpression and overactivation of Stat3 was found in EOC tissues, and the constitutive activation of Stat3 signaling pathway may play an important role in the invasion and prognosis of EOC.

Leukotriene B4 Receptor-2 Promotes Invasiveness and Metastasis of Ovarian Cancer Cells through Signal Transducer and Activator of Transcription 3 (STAT3)-dependent Up-regulation of Matrix Metalloproteinase 2

“…5). STAT3 has previously been shown to be of potential prognostic relevance in ovarian cancer (11,28,29,41). In particular, activation of STAT3 and its translocation to the nucleus are frequent events in ovarian carcinoma (41), and the levels of phosphorylated STAT3 were found to correlate with disease stage, differentiation of carcinoma, and the presence of lymph node metastasis (11).…”

“…The transcription factor STAT3, which exists in a latent form in the cytosol, also regulates MMP2 expression through direct interaction with the MMP2 gene promoter (8), with inhibition of STAT3 also resulting in down-regulation of MMP2 expression (9). In addition, STAT3 was found to be overexpressed in ovarian cancer cell lines and ovarian cancer tissue, with constitutive activation of STAT3 signaling being implicated in invasion and metastasis in ovarian cancer (10,11). Despite this association of STAT3 with ovarian cancer progression, however, the upstream signaling pathway responsible for activation of the STAT3-MMP2 axis in ovarian cancer cells has remained unknown.…”

Inhibition of STAT3 activity delays obesity-induced thyroid carcinogenesis in a mouse model

“…Importantly, the upregulated STAT3 expression is associated with more malignant behavior of tumor cells and worse prognosis in a variety of human malignancies, such as cancer of lung, prostate, head and neck, ovarian, breast, gastric, pancreas, and thyroid (Wei et al 2003, Masuda et al 2007, Yakata et al 2007, Sheen-Chen et al 2008, Min & Wei-hong 2009, Zhang et al 2011, Ai et al 2012, Liu et al 2012, Dong et al 2014. The increased expression and activation of STAT3 are detected in the tissue specimens of thyroid cancer, including lymphatic metastasis of papillary thyroid cancer in affected patients (Zhang et al 2011, Dong et al 2014.…”

HO-3867, a curcumin analog, sensitizes cisplatin-resistant ovarian carcinoma, leading to therapeutic synergy through STAT3 inhibition

“…[32][33][34] We first analyzed the levels of pSTATs in A2780R, as well as its cisplatin-sensitive variant A2780 cells. While there were no differences in the expression levels of pSTAT1, pSTAT2, pSTAT5 and pSTAT6 between the two cells, there was a 2-fold increase in the expression of pSTAT3…”