2020
DOI: 10.1016/j.neuropharm.2020.107967
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Constitutive activity of 5-HT receptors: Factual analysis

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Cited by 48 publications
(36 citation statements)
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“…An additional complexity in learning and memory processes is that some learning responses such as the conditioned eyeblink response in rabbits or the auto-shaping learning task in rats are independent of the levels of 5-HT [188,189]. These responses are sensitive to some inverse agonists suggesting that the controls exerted by some 5-HTRs over learning processes can involve the constitutive activity of some 5-HTRs including 5-HT 2A R and 5-HT 2B/2C R [190][191][192].…”
Section: Moodmentioning
confidence: 99%
“…An additional complexity in learning and memory processes is that some learning responses such as the conditioned eyeblink response in rabbits or the auto-shaping learning task in rats are independent of the levels of 5-HT [188,189]. These responses are sensitive to some inverse agonists suggesting that the controls exerted by some 5-HTRs over learning processes can involve the constitutive activity of some 5-HTRs including 5-HT 2A R and 5-HT 2B/2C R [190][191][192].…”
Section: Moodmentioning
confidence: 99%
“…The serotonergic system modulates a diverse variety of physiological functions, such as thermoregulation, sexual and aggressive behavior, learning and memory, endocrine and gastrointestinal functions, and food intake, among others [1]. In order to perform these different tasks, the neurotransmitter 5-hydroxytryptamine (5-HT) interacts with various receptor subtypes among which the 5-HT 6 receptor (5-HT 6 R) is one of the most recently discovered, about a quarter of a century ago [2]. The 5-HT 6 R is involved in several physiological functions, such as learning, memory, and neurodevelopment, and diverse pathological states, such as eating disorders, anxiety, depression, addictive behavior, schizophrenia, epilepsy and Alzheimer's disease [3][4][5][6][7][8].…”
Section: Introductionmentioning
confidence: 99%
“…recently discovered, about a quarter of a century ago [2]. The 5-HT6R is involved in seve physiological functions, such as learning, memory, and neurodevelopment, and diver pathological states, such as eating disorders, anxiety, depression, addictive behavi schizophrenia, epilepsy and Alzheimer's disease [3][4][5][6][7][8].…”
Section: Introductionmentioning
confidence: 99%
“…The serotonin (5-hydroxytryptamine) receptor 5-HT6 (5-HT6R) is exclusively expressed in both the developing and the mature nervous systems (Roberts et al, 2002;Dayer et al, 2015;Helboe et al, 2015). It is highly expressed in mnemonic regions such as the olfactory tubercle, striatum, nucleus accumbens, and hippocampus (De Deurwaerdere et al, 2020). Studies have proven that it plays important roles in neuronal migration, neuronal differentiation, and neurite growth (Roberts et al, 2002;Dayer et al, 2015;De Deurwaerdere et al, 2020).…”
Section: Introductionmentioning
confidence: 99%
“…It is highly expressed in mnemonic regions such as the olfactory tubercle, striatum, nucleus accumbens, and hippocampus (De Deurwaerdere et al, 2020). Studies have proven that it plays important roles in neuronal migration, neuronal differentiation, and neurite growth (Roberts et al, 2002;Dayer et al, 2015;De Deurwaerdere et al, 2020). Considering its particular distribution, 5-HT6R has recently been targeted to alleviate cognitive impairment, especially hippocampus-dependent learning and memory impairment (Seo and Tsai, 2014;Dayer et al, 2015;Karila et al, 2015;Aparicio-Nava et al, 2019).…”
Section: Introductionmentioning
confidence: 99%