Constitutive expression of the anti-apoptotic Bcl-2 family member A1 in murine endothelial cells leads to transplant tolerance

Smyth, Lesley A.; Meader, Lucy; Xiao, Fang; Woodward, Martin J.; Brady, Hugh J.M.; Lechler, Robert I.; Lombardi, Giovanna

doi:10.1111/cei.12931

Cited by 5 publications

(1 citation statement)

References 35 publications

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“…Moreover, inhibition of BAX prevents cardiotoxicity induced by doxorubicin in zebrafish and mice without affecting the anti-neoplastic activity of doxorubicin [ 249 ]. Similarly, the endothelial cell-specific expression of B cell leukemia/lymphoma 2 related protein A1a (BCL2A1A) promotes survival in a model of allogeneic heart transplantation [ 250 ].…”

Section: Intrinsic Apoptosis In Diseasementioning

confidence: 99%

Apoptotic cell death in disease—Current understanding of the NCCD 2023

et al. 2023

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Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis in mammalian systems have elucidated the key contribution of this process not only to (post-)embryonic development and adult tissue homeostasis, but also to the etiology of multiple human disorders. Consistent with this notion, while defects in the molecular machinery for apoptotic cell death impair organismal development and promote oncogenesis, the unwarranted activation of apoptosis promotes cell loss and tissue damage in the context of various neurological, cardiovascular, renal, hepatic, infectious, neoplastic and inflammatory conditions. Here, the Nomenclature Committee on Cell Death (NCCD) gathered to critically summarize an abundant pre-clinical literature mechanistically linking the core apoptotic apparatus to organismal homeostasis in the context of disease.

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Section: Intrinsic Apoptosis In Diseasementioning

confidence: 99%