Constitutive nitric oxide synthase gene polymorphisms and house dust mite respiratory allergy in an Algerian patient group

Djidjik, Réda; Ghaffor, M; Brun, Marion; Gharnaout, M.; Salah, Samir; Boukouaci, Wahid; Djidjik, Hicham; Benyounes, A.; Koumaravelou, Kailasam; Krishnamoorthy, R.; Abbadi, Mohamed Chérif; Charron, Dominique; Tamouza, Ryad

doi:10.1111/j.1399-0039.2007.00976.x

Cited by 8 publications

(4 citation statements)

References 38 publications

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“…Our study represents an investigation of the role of the eNOS gene in asthma in the Czech population. Despite biological plausibility, only a few studies have examined the influence of selected variants in the eNOS gene in allergic diseases, including asthma [15][16][17][18][19][20][21]36]. Findings from these studies are contradictory, possibly reflecting small sample size, study of different populations, and testing of polymorphisms in isolation, which can be misleading.…”

Section: Discussionmentioning

confidence: 90%

Haplotype analysis of the endothelial nitric oxide synthase gene in asthma

et al. 2008

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Section: Discussionmentioning

confidence: 90%

Haplotype analysis of the endothelial nitric oxide synthase gene in asthma

et al. 2008

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“…OMIM lists several genes. Arab studies: 786 T > C [rs2070744] from the 5’ flanking region of NOS3 (OMIM lists this variant but the variant is not seen in Kuwaiti exomes) 140 . Risk Factor for common disorder AD 7/55/212 0.1259/0.0595/0.0968 2.1159/1.3009 rs1801483 (G_A) GCGR SAFD Variant T2DM (PMIM: 125853).…”

Section: Resultsmentioning

confidence: 99%

Assessment of coding region variants in Kuwaiti population: implications for medical genetics and population genomics

John

Antony

Eaaswarkhanth

et al. 2018

Sci Rep

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Consanguineous populations of the Arabian Peninsula have been underrepresented in global efforts that catalogue human exome variability. We sequenced 291 whole exomes of unrelated, healthy native Arab individuals from Kuwait to a median coverage of 45X and characterised 170,508 single-nucleotide variants (SNVs), of which 21.7% were ‘personal’. Up to 12% of the SNVs were novel and 36% were population-specific. Half of the SNVs were rare and 54% were missense variants. The study complemented the Greater Middle East Variome by way of reporting many additional Arabian exome variants. The study corroborated Kuwaiti population genetic substructures previously derived using genome-wide genotype data and illustrated the genetic relatedness among Kuwaiti population subgroups, Middle Eastern, European and Ashkenazi Jewish populations. The study mapped 112 rare and frequent functional variants relating to pharmacogenomics and disorders (recessive and common) to the phenotypic characteristics of Arab population. Comparative allele frequency data and carrier distributions of known Arab mutations for 23 disorders seen among Arabs, of putative OMIM-listed causal mutations for 12 disorders observed among Arabs but not yet characterized for genetic basis in Arabs, and of 17 additional putative mutations for disorders characterized for genetic basis in Arab populations are presented for testing in future Arab studies.

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“…Six were selected based on the literature (ie, previously reported association with FENO, asthma, and other respiratory phenotypes) rs2682826,20 rs41279104,28 rs2255929,29 rs3918226,30 rs3918169,30 rs154975831 and were complemented with 48 tagging SNPs to capture genetic variation across each gene (supplementary table 1). Tag SNP selection was done using the HapMap phase III European ancestry data (http://www.hapmap.org) with a pairwise approach (r 2 ≥0.8) for SNPs with minor allele frequency ≥0.05, extending to 100 kb upstream and 50 kb downstream of each gene.…”

Section: Methodsmentioning

confidence: 99%