Constitutive secretion of chemokines by cultured human trabecular meshwork cells

Shifera, Amde Selassie; Trivedi, Sheetal; Chau, Phuonglan; Bonnemaison, Lucia H.; Iguchi, Rumiko; Alvarado, Jorge A.

doi:10.1016/j.exer.2010.04.001

Cited by 53 publications

(35 citation statements)

References 14 publications

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“…For instance, MMP-3 has in several studies been proven to be beneficial by increasing aqueous humor out-flow, thus reducing IOP. 7,25,34,72 Nonetheless, MMP-9 has been demonstrated to promote RGC loss due to the lack of significant RGC apoptosis in MMP-9 knock-out mice. 12 Thus, it appears that the presence of inflammatory TNF-a and ILs result in different effects in response to which cells they influence and which MMPs they induce.…”

Section: Increased Expression Of Matrix Metalloproteinases Resultsmentioning

confidence: 96%

The Role of Inflammation in the Pathogenesis of Glaucoma

Vohra

Tsai

Kolko

2013

Survey of Ophthalmology

188

149

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Section: Increased Expression Of Matrix Metalloproteinases Resultsmentioning

confidence: 96%

The Role of Inflammation in the Pathogenesis of Glaucoma

Vohra

Tsai

Kolko

2013

Survey of Ophthalmology

188

149

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“…Incredibly, TM cells produce one hundred times more tPA than vascular endothelia, emphasizing the importance of passageway patency (Snyder et al, 1993, Shuman et al, 1988). Also like endothelia, cells from the inner TM participate in antigen presentation and inflammation mediation, producing major histocompatibility proteins and a wide array of inflammatory cytokines, respectively (Shifera et al, 2010, Tripathi et al, 1990a, Latina et al, 1988, Lynch et al, 1987). In fact, laser trabeculoplasty takes advantage of the TM’s role in local inflammatory mediation and resolution to decrease outflow resistance.…”

Section: Trabecular Meshwork Structure and Functionmentioning

confidence: 99%

The many faces of the trabecular meshwork cell

Stamer

Clark

2017

Experimental Eye Research

213

215

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With the combined purpose of facilitating useful vision over a lifetime, a number of ocular cells have evolved specialized features not found elsewhere in the body. The trabecular meshwork (TM) cell at the irido-corneal angle, which is a key regulator of intraocular pressure, is no exception. Examination of cells in culture isolated from the human TM has shown that they are unique in many ways, displaying characteristic features of several different cell types. Thus, these neural crest derived cells display expression patterns and behaviors typical of endothelia, fibroblasts, smooth muscle and macrophages, owing to the multiple roles and two distinct environments where they operate to maintain intraocular pressure homeostasis. In most individuals, TM cells function normally over a lifetime in the face of persistent stressors, including phagocytic, oxidative, mechanical and metabolic stresses. Study of TM cells isolated from ocular hypertensive eyes has shown a compromised ability to perform their daily duties. This review highlights the many responsibilities of the TM cell and its challenges, progress in our understanding of TM biology over the past 30 years, as well as discusses unanswered questions about TM dysfunction that results in IOP dysregulation and glaucoma.

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“…Celles-ci pourraient participer à la trabéculopathie glaucomateuse, en modulant l'inflammation locale et le recrutement des cellules immunes, la peroxydation lipidique et la production de ROS [64], ainsi que certains processus de fibrose tissulaire [52]. Certaines cytokines singulières, les chimiokines, impliquées dans l'homéostasie et l'inflammation du microenvironnement tissulaire, ont été identifiées au sein de la conjonctive [65,66], de la cornée [67,68], mais aussi du trabéculum [69,70] (Fig. 2).…”

Section: La Cellule Trabéculaire : Une Cible Thérapeutique De Choix ?unclassified