Constrained Photophysics of 5,7-dimethoxy-2,3,4,9-tetrahydro-1H-carbazol-1-one in the Bioenvironment of Serum Albumins: A Spectroscopic Endeavour Supported by Molecular Docking Analysis

Abstract

This paper vividly indicates that steady state as well as time-resolved fluorescence techniques can serve as highly sensitive monitors to explore the interactions of 5,7-dimethoxy-2,3,4,9-tetrahydro-1H-carbazol-1-one with model transport proteins, bovine serum albumin (BSA) and human serum albumin (HSA). Besides these, we have used fluorescence anisotropy study to assess the degree of restrictions imparted by the micro-environments of serum albumins. Again, to speculate the triplet excited state interaction between such fluorophore and albumin proteins (BSA& HSA), laser flash-photolysis experiments have been carried out. Molecular docking experiments have also been performed to support the conclusions obtained from steady state experiments.

The versatility of DABCO as a reagent in organic synthesis: a review

“…71,72 Several derivatives of 2,3,4,9-tetrahydro-1H-carbazol-1-one (77), a synthetic precursor of carbazole have recently garnered a wide interest owing to their potential as fluorophores. [72][73][74][75][76][77][78][79][80][81][82][83][84] Indumathi et al used derivatives of 2,3,4,9-tetrahydro-1H-carbazol-1-one (77), malononitrile and aromatic/heteroaromatic aldehyde in a DABCO catalyzed multicomponent reaction to produce benzo[a]carbazoles (79) (Scheme 27). 71 Table 17 portrays the variation of yield of benzo[a]carbazoles using a DABCO catalyzed multicomponent reaction with change in derivatives of 2,3,4,9-tetrahydro-1H-carbazol-1-one and aromatic aldehyde.…”

“…They used DABCO as a catalyst in the aza Baylis-Hillman reaction. In the presence of a DABCO catalyst, they employed SES-NH 2 (82) to produce a series of SES-protected β-aminoesters (85). These synthesized β-aminoesters were subsequently used to design a variety of 2,3-disubstituted pyrroles (86) via a ring-opening mechanism, as indicated in Scheme 29.…”

“…71,72 Several derivatives of 2,3,4,9-tetrahydro-1 H -carbazol-1-one ( 77 ), a synthetic precursor of carbazole have recently garnered a wide interest owing to their potential as fluorophores. 72–84 Indumathi et al used derivatives of 2,3,4,9-tetrahydro-1 H -carbazol-1-one ( 77 ), malononitrile and aromatic/heteroaromatic aldehyde in a DABCO catalyzed multicomponent reaction to produce benzo[ a ]carbazoles ( 79 ) (Scheme 27). 71…”