Textural evidence from occurrences of mingled magmas in lava flows often yields insights into chemical and thermal disequilibrium between multiple magma batches at depth. An understanding of these interactions is key as they can occur on short timescales and may act as eruption triggers, particularly important in very active volcanic settings. This paper focuses on the Pietre Cotte lava flow (Vulcano, Aeolian Islands, Italy), a short (<1 km in length), texturally-heterogeneous rhyolitic extrusion on the northern slope of the active Fossa Cone. The occurrence of (i) multiple magma compositions, (ii) distinct magmatic cumulates (as glomerocrysts) and (iii) mineral resorption textures within glomerocrysts and isolated feldspar phenocrysts in the Pietre Cotte lava flow highlight a complex pre-eruptive magmatic history, including crystal mush remobilisation. Petrographic observations and mineral, bulk rock and glass geochemistry suggest that multiple mingling events occurred during the evolution of the Pietre Cotte magmatic system, evidenced by the recognition of the following components: (1) a remobilised predominantly mafic crystal mush, evident as macrocrysts (crystals >500 µm), which form glomerocrysts within enclaves, (2) a microlitic (<100 µm) trachytic enclave groundmass with microcrysts (100-500 µm), and (3) a rhyolitic glass, which hosts both the enclaves and the glomerocrysts. The macrocrystic mafic assemblage includes clinopyroxene (En 38-47 Wo 45-50 ; Mg# 0.72-0.89), olivine (Fo 49-66) and magnetite (Usp 7-26), with plagioclase (An 40-63 Ab 5-50) and rare alkali feldspar (Or 41-57) also present. Enclaves are comprised of a groundmass of plagioclase (An 43-47) and alkali feldspar (Or 33-57) microlites, with clinopyroxene microcrysts (En 39-42 Wo 47-51 ; Mg# 0.75-0.81) and trachyte groundmass glass. The rhyolitic host is characterised by glass, spherulites, microlites and enclave-derived macrocrysts.