Constraining the Teratogenicity of Pesticide Pollution by a Synthetic Nanoreceptor

Yang, Xue; Li, Shengke; Wang, Ziyi; Lee, Simon Ming‐Yuen; Wang, Lian Hui; Wang, Ruibing

doi:10.1002/asia.201701527

Cited by 17 publications

(7 citation statements)

References 30 publications

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“…Antidotes against nereistoxin derivatives poisoning include classical British anti-lewisite and sodium dimercaptopropane sulfonate [ 43 ]. Moreover, new chelators called “nanoreceptors” have been proposed recently to oppose the toxicity of nereistoxin [ 46 ].…”

Section: Marine Low Molecular Weight Compounds Targeting Nachrsmentioning

confidence: 99%

Marine Origin Ligands of Nicotinic Receptors: Low Molecular Compounds, Peptides and Proteins for Fundamental Research and Practical Applications

et al. 2022

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The purpose of our review is to briefly show what different compounds of marine origin, from low molecular weight ones to peptides and proteins, offer for understanding the structure and mechanism of action of nicotinic acetylcholine receptors (nAChRs) and for finding novel drugs to combat the diseases where nAChRs may be involved. The importance of the mentioned classes of ligands has changed with time; a protein from the marine snake venom was the first excellent tool to characterize the muscle-type nAChRs from the electric ray, while at present, muscle and α7 receptors are labeled with the radioactive or fluorescent derivatives prepared from α-bungarotoxin isolated from the many-banded krait. The most sophisticated instruments to distinguish muscle from neuronal nAChRs, and especially distinct subtypes within the latter, are α-conotoxins. Such information is crucial for fundamental studies on the nAChR revealing the properties of their orthosteric and allosteric binding sites and mechanisms of the channel opening and closure. Similar data are provided by low-molecular weight compounds of marine origin, but here the main purpose is drug design. In our review we tried to show what has been obtained in the last decade when the listed classes of compounds were used in the nAChR research, applying computer modeling, synthetic analogues and receptor mutants, X-ray and electron-microscopy analyses of complexes with the nAChRs, and their models which are acetylcholine-binding proteins and heterologously-expressed ligand-binding domains.

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Section: Marine Low Molecular Weight Compounds Targeting Nachrsmentioning

confidence: 99%

Marine Origin Ligands of Nicotinic Receptors: Low Molecular Compounds, Peptides and Proteins for Fundamental Research and Practical Applications

et al. 2022

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“…For instance, CB[8] played a critical role on formulating a safe, photo-responsive herbicide formulation (Gao et al, 2018). CB [7] was previously reported to inhibit the non-specific teratogenic toxicity of a couple of representative pesticides on a zebrafish model, through a facile supramolecular encapsulation (Yang et al, 2018). In addition, CB[7] was studied for its encapsulation of trazodone (TZ), an anti-depression drug approved by the FDA, but can cause liver damage due to its toxicity (Huang et al, 2018b).…”

Section: Encapsulations Of Ana By Cb[7] and β-Cdmentioning

confidence: 99%

Supramolecular Nano-Encapsulation of Anabasine Reduced Its Developmental Toxicity in Zebrafish

et al. 2020

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Anabasine (ANA), a major piperidine alkaloid originally isolated from wild tobacco trees (Nicotiana glauca), has been known to induce serious developmental toxicities such as skeletal deformities in livestock and humans. In this study, we thoroughly investigated the supramolecular nano-encapsulations of ANA by an artificial nanocontainer, cucurbit[7] uril (CB[7]), and examined the influences of the nano-encapsulation on ANA's inherent developmental toxicities on a zebrafish model. We have shown that CB[7] formed 1:1 host-guest inclusion complexes with ANA via a relatively high binding strength [K a of (7.45 ± 0.31) × 10 4 M −1 ] in an aqueous solution, via UV-vis and 1 H nuclear magnetic resonance spectroscopic titrations, as well as isothermal titration calorimetry titration. As a consequence, CB[7] significantly attenuated the developmental toxicity of ANA on zebrafish in vivo. In contrast, for a comparative purpose, β-CD didn't exert any influence on the toxicity of ANA due to its weak binding with ANA, which was not even measurable via either spectroscopic methods or ITC titration. This is the first head-to-head comparison of this pair of nanocontainers, CB[7] and β-CD, on their potential roles in influencing the toxicity of guest molecules and the results suggested that CB[7] could become a more promising functional excipient for reducing the inherent toxicities of active pharmaceutical ingredients, particularly alkaloids that may form relatively strong host-guest binding species with the host.

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“…The use of pesticides for processing crops leads to the inclusion of pesticides in the food chain, which determines the high risk of these pollutants for ecosystems in general, as well as for human health. Pesticides have reproductive toxicity [1,2], teratogenic activity [3,4,5], are endocrine disruptors [1,6], reduce the activity of humoral immunity [7], have epigenetic activity [8,9]. Long-term direct contacts with pesticides of people, working in agriculture, signi cantly increase the risk of developing cancer, diseases of the immune and nervous systems [10,11,12].…”

Section: Introductionmentioning

confidence: 99%

Cytological Effects of Herbicidal and Fungicidal Pesticides on Root Apex Meristem Cells of Triticum Aestivum

Menzyanova

Shishatskaya

Pyatina

et al. 2020

Preprint

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Using the example of 2-day-old Triticum aestivum seedlings, grown in hydroponic culture, the cytological effects of pesticides with various mechanisms of the damaging were studied: the herbicides metribuzin, tribenuron-methyl, fenoxaprop-P-ethyl and the fungicides tebuconazole, epoxiconazole, and azoxystrobin. All pesticides showed a dose-dependent inhibitory effect on the development of the roots of Triticum aestivum, but did not affect the mitotic activity and did not reduce the mitotic index of root apex meristem cells. Herbicides and fungicides affected the duration of metaphase, anophase, prophase, and cytokinesis activity in the root apex meristem of the wheat, and these changes were specific for the six studied preparations. Under the influence of all pesticides, the number of abnormal cells increased significantly, to the greatest extent (10–12 times compared with control - distilled water) under the influence of herbicides tribenuron-methyl and phenoxaprop-ethyl and fungicides azoxystrobin and epoxiconazole; to a lesser extent - under the influence of metribuzin and tebuconazole (6–7 times). For all studied pesticides the manifestation of cyto- and genotoxicity, including both clastogenic and aneugenic effects, was revealed in relation to the non-target plant Triticum aestivum. Under the influence of pesticides, structural anomalies, caused by chromosome breakdown (bridges, fragments, micronuclei) and spindle damage (lagging chromosomes and their fragments, uneven chromosome separation) were detected in the cells of the Triticum aestivum root apex meristem.

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Constraining the Teratogenicity of Pesticide Pollution by a Synthetic Nanoreceptor

Cited by 17 publications

References 30 publications

Marine Origin Ligands of Nicotinic Receptors: Low Molecular Compounds, Peptides and Proteins for Fundamental Research and Practical Applications

Marine Origin Ligands of Nicotinic Receptors: Low Molecular Compounds, Peptides and Proteins for Fundamental Research and Practical Applications

Supramolecular Nano-Encapsulation of Anabasine Reduced Its Developmental Toxicity in Zebrafish

Cytological Effects of Herbicidal and Fungicidal Pesticides on Root Apex Meristem Cells of Triticum Aestivum

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