Organic horticulture producers rank weeds as one of their most troublesome, time-consuming, and costly production problems. With the increasing significance of organic horticulture, the need for new bioherbicides to control weeds has grown. Potential bioherbicides may be developed from pathogens, natural products, and extracts of natural materials. Fungal and bacteria pathogens are two important types of microbial agents that have potential to be used as bioherbicides. The byproducts of natural sources such as dried distillers grains with solubles (DDGS), corn gluten meal (CGM), and mustard seed meals (MSMs) have shown herbicidal activities in controlling many weed species. Some essential oil extracts have shown bioherbicide potential as well. The efficacy of a bioherbicide is the main limiting factor for its application, and it may be affected by environmental factors such as humidity and moisture, the application method, the spectrum of the bioherbicide, and the type of formulation. In addition to efficacy, costs and concerns about potential human health threats are also limitations to bioherbicide use. As the integration of bioherbicide technology into current weed management systems may help manage herbicide resistance, reduce production costs, and increase crop yields, future research should involve the development of more cost-effective and efficient bioherbicides for control of weeds, as well as the optimization of production methods and cultural practices with use of candidate bioherbicides.