Under glacial climates, continental ice sheets such as, e.g., the Greenland Ice Sheet, extended onto the continental shelves and often carved out deep cross-shelf troughs. The sedimentary infill of such troughs commonly is a product of the complex interactions between the ice sheets, largely driving sediment input into the ocean, and the surrounding water masses. Off West Greenland, research has focused on the Disko and Uummannaq troughs, leaving the northerly adjacent Upernavik trough relatively understudied. Hence, neither the chronology of deglaciation nor the details of its postglacial infill are sufficiently well understood. Here, we combine computed tomography image-derived information with geochemical and granulometric data from four sediment cores recovered from the Upernavik trough that point to (i) deglaciation of the mid-shelf probably around 13.4 cal. ka BP that was most likely driven by a northward advection of warmer Atlantic waters during the Bølling-Allerød, (ii) the presence of widespread mass wasting around 8 cal. ka BP on the inner shelf and (iii) the complex interplay between various modes of sediment input, transport and deposition under hemipelagic sedimentation afterwards. While this interplay complicates provenance studies, we identify two major sediment delivery mechanisms that control transport and deposition from four sediment source areas. Through the Early Holocene the relative contributions of sediments from the various sources changed from a predominantly local origin to more southerly sources, mainly driven by decreasing input from the local sources. The integration of relative sediment source contributions with varying sedimentation rates challenges previous studies postulating intensified sediment delivery from the south through a greater influence of the West Greenland Current and highlights the need for the integration of sediment input and transport mechanisms into provenance studies in the area.