Constraints on the use of lifespan-shortening Wolbachia to control dengue fever

Schraiber, Joshua G.; Kaczmarczyk, Angela N.; Kwok, Ricky; Park, Mi-Ran; Silverstein, Rachel; Rutaganira, Florentine U.; Aggarwal, Taruna; Schwemmer, Michael A.; Hom, Carole L.; Grosberg, Richard K.; Schreiber, Sebastian J.

doi:10.1016/j.jtbi.2011.12.006

Cited by 60 publications

(80 citation statements)

References 34 publications

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“…Additionally, our model comprises so-called "Allee effect" or critical depensation(see, e.g., [17,26] or other similar textbooks) which exhibit uninfected mosquitoes at high frequencies of Wolbachia. This effect was observed in other models describing Wolbachia invasion [3,29,34].…”

Section: Thatsupporting

confidence: 71%

“…Additionally, several scholars observed that uninfected individuals exhibit so-called Allee effect or critical depensation at high Wolbachia frequencies [3,29,34]. In other words, if the density of wild mosquitoes N f (t) drops below some critical threshold 0 < K 0 < K while Wolbachia-carries have a relatively high density, the population of wild mosquitoes will be gradually driven towards extinction.…”

Section: Modelling Frameworkmentioning

confidence: 99%

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OPTIMAL CONTROL FOR ENHANCEMENT OF \emph{WOLBACHIA} FREQUENCY AMONG \emph{AEDES AEGYPTI} FEMALES

Campo-Duarte¹,

Vasilieva²,

Cardona-Salgado³

2017

Int. J. of Pure and Appl. Math.

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In this paper, we propose and thoroughly analyze the ODE model that describes the competition between wild Aedes aegypti female mosquitoes and those carrying Wolbachia bacterial symbiont in the same locality. Using this model in the context of optimal control, we further propose feasible strategies for replacing the wild population with Wolbachia-carriers.The latter is known as Wolbachia-based biocontrol aimed at prevention of various arboviral infections (such as dengue, chikungunya, and zika diseases), given that Wolbachia drastically reduces the mosquito ability to acquire arboviral infections.

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Section: Thatsupporting

confidence: 71%

Section: Modelling Frameworkmentioning

confidence: 99%

OPTIMAL CONTROL FOR ENHANCEMENT OF \emph{WOLBACHIA} FREQUENCY AMONG \emph{AEDES AEGYPTI} FEMALES

Campo-Duarte¹,

Vasilieva²,

Cardona-Salgado³

2017

Int. J. of Pure and Appl. Math.

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“…A continuous time non-spatial model and a reaction-diffusion model incorporating lifespan shortening and CI were developed to study factors that determine the spatial spread of Wolbachia through a population of female Aedes aegypti mosquitoes assuming constant population size and perfect maternal transmission of Wolbachia [46]. A two-sex deterministic model with deterministic immature life stages and stochastic female adult life stage was developed to understand Wolbachia invasion into uninfected host population [6].…”

Section: Existing Mosquito-wolbachia Modelsmentioning

confidence: 99%

Two-sex mosquito model for the persistence ofWolbachia

Xue

Manore

Thongsripong

et al. 2016

Journal of Biological Dynamics

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We develop and analyse an ordinary differential equation model to investigate the transmission dynamics of releasing Wolbachiainfected mosquitoes to establish an endemic infection in a population of wild uninfected mosquitoes. Wolbachia is a genus of endosymbiotic bacteria that can infect mosquitoes and reduce their ability to transmit some viral mosquito-transmitted diseases, including dengue fever, chikungunya, and Zika. Although the bacterium is transmitted vertically from infected mothers to their offspring, it can be difficult to establish an endemic infection in a wild mosquito population. Our transmission model for the adult and aquatic-stage mosquitoes takes into account Wolbachia-induced fitness change and cytoplasmic incompatibility. We show that, for a wide range of realistic parameter values, the basic reproduction number, R 0 , is less than one. Hence, the epidemic will die out if only a few Wolbachiainfected mosquitoes are introduced into the wild population. Even though the basic reproduction number is less than one, an endemic Wolbachia infection can be established if a sufficient number of infected mosquitoes are released. This threshold effect is created by a backward bifurcation with three coexisting equilibria: a stable zeroinfection equilibrium, an intermediate-infection unstable endemic equilibrium, and a high-infection stable endemic equilibrium. We analyse the impact of reducing the wild mosquito population before introducing the infected mosquitoes and observed that the most effective approach to establish the infection in the wild is based on reducing mosquitoes in both the adult and aquatic stages. ARTICLE HISTORY

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“…Because it is only the relatively old females that transmit disease, even small decreases in adult lifespan can have a large effect on vectorial capacity. Population modelling suggests there is a window of parameter space in which a life-shortening Wolbachia strain can significantly reduce dengue transmission and still spread [55,56]. …”

Section: Self-sustaining Strategiesmentioning

confidence: 99%

Heritable strategies for controlling insect vectors of disease

Burt

2014

Phil. Trans. R. Soc. B

193

200

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Mosquito-borne diseases are causing a substantial burden of mortality, morbidity and economic loss in many parts of the world, despite current control efforts, and new complementary approaches to controlling these diseases are needed. One promising class of new interventions under development involves the heritable modification of the mosquito by insertion of novel genes into the nucleus or of Wolbachia endosymbionts into the cytoplasm. Once released into a target population, these modifications can act to reduce one or more components of the mosquito population's vectorial capacity (e.g. the number of female mosquitoes, their longevity or their ability to support development and transmission of the pathogen). Some of the modifications under development are designed to be self-limiting, in that they will tend to disappear over time in the absence of recurrent releases (and hence are similar to the sterile insect technique, SIT), whereas other modifications are designed to be self-sustaining, spreading through populations even after releases stop (and hence are similar to traditional biological control). Several successful field trials have now been performed with Aedes mosquitoes, and such trials are helping to define the appropriate developmental pathway for this new class of intervention.

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Constraints on the use of lifespan-shortening Wolbachia to control dengue fever

Cited by 60 publications

References 34 publications

OPTIMAL CONTROL FOR ENHANCEMENT OF \emph{WOLBACHIA} FREQUENCY AMONG \emph{AEDES AEGYPTI} FEMALES

OPTIMAL CONTROL FOR ENHANCEMENT OF \emph{WOLBACHIA} FREQUENCY AMONG \emph{AEDES AEGYPTI} FEMALES

Two-sex mosquito model for the persistence ofWolbachia

Heritable strategies for controlling insect vectors of disease

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