We consider the diffuse gamma ray data from Fermi first year observations and compare them to the gamma ray fluxes predicted by Dark Matter annihilation or decay (both from prompt emission and from Inverse Compton Scattering), for different observation regions of the sky and a range of Dark Matter masses, annihilation/decay channels and Dark Matter galactic profiles. We find that the data exclude large regions of the Dark Matter parameter space not constrained otherwise and discuss possible directions for future improvements. Also, we further constrain Dark Matter interpretations of the e ± PAMELA/Fermi spectral anomalies, both for the annihilating and the decaying Dark Matter case: under very conservative assumptions, only models producing dominantly µ ± and assuming a cored Dark Matter galactic profile can fit the lepton data with masses around ∼ 2 TeV.