For patients with liver disease undergoing laparoscopic hepatectomy due to long-term pain and surgical trauma, most patients have great psychological pressure and stress response during treatment, which seriously affects the operation effect and postoperative recovery. Based on the above background, the purpose of this study is to explore the application of fast track surgical nursing mode in perioperative period of laparoscopic liver cancer resection. In this study, 80 patients with hepatocellular carcinoma were randomly divided into two groups, the experimental group and the control group. There were 40 cases in the experimental group and 40 cases in the control group. The control group adopted the traditional weekly nursing management mode for nursing, and the experimental group adopted the intervention measures of rapid rehabilitation surgery nursing concept. The operation time, neck drainage volume, CPR concentration, pain score, restlessness score, patient satisfaction, hospitalization expenses and length of stay were compared between the two groups. The data were processed by SPPs 19.0 software. Independent sample t-test was used for measurement data, P<0.05, with statistical significance. The experimental results show that although the effect of rapid rehabilitation surgery nursing concept intervention cannot affect the operation time and postoperative drainage volume, it can reduce the postoperative pain of patients, reduce the anxiety of patients, improve the satisfaction of patients, shorten the length of hospital stay, reduce the cost of hospitalization.