Constructing a defect-rich hydroxide nanoenzyme sensor based on dielectric barrier discharge microplasma etching for sensitive detection of thiamine hydrochloride and hydrogen peroxide

Defect-containing metal–organic framework materials for sensor applications

“…Furthermore, derivatives of defect-rich MOFs have also exhibited exceptional sensing performance. For instance, Hu et al 91 created a defect-rich Co(OH) 2 nanoenzyme sensor from MOF-derived cobalt via a room-temperature reaction and chemical etching with dielectric barrier discharge microplasma (Fig. 9a).…”

Nanozymes: Applications in clinical biomarker detection

“…For example, Huang and coworkers synthesized defect-rich cobalt hydroxide (D-Co (OH) 2 ) with POD-like activity for the direct detection of H 2 O 2 in Hela cells. 62 Xiao and colleagues successfully constructed gold nanoparticles wrapped MnO 2 nanowires (MnO 2 @Au) to modify graphene fiber (GF) as the electrode. The obtained dual nanozyme microelectrode could detect H 2 O 2 in liver cancer cells.…”

“…In addition to nanomaterials mentioned above, electrochemical sensors for H 2 O 2 with the aid of nanozymes with POD‐like activity have been extensively studied. For example, Huang and co‐workers synthesized defect‐rich cobalt hydroxide (D‐Co(OH) 2 ) with POD‐like activity for the direct detection of H 2 O 2 in Hela cells 62 . Xiao and colleagues successfully constructed gold nanoparticles wrapped MnO 2 nanowires (MnO 2 @Au) to modify graphene fiber (GF) as the electrode.…”

Plasma Meets MOFs: Synthesis, Modifications, and Functionalities

“…Recently, the study on sensing of water‐soluble substances by plasma‐assisted MOFs has also made some progress. Hu and co‐workers designed a hydroxide nanoenzyme sensor with a high defect content using the transition metal cobalt generated from MOFs which were prepared by room‐temperature reaction and chemical etching by DBD microplasma [169] . In this study, Co MOF/Carbon Cloth (CC) and defect‐rich (D)‐Co(OH) 2 /Carbon Cloth were constructed by a two‐step method and DBD microplasma chemical etching for the detection of thiamine hydrochloride (TCL) in alkaline and H 2 O 2 in neutral (Figure 14).…”

“…Hu and co-workers designed a hydroxide nanoenzyme sensor with a high defect content using the transition metal cobalt generated from MOFs which were prepared by room-temperature reaction and chemical etching by DBD microplasma. [169] In this study, Co MOF/Carbon Cloth (CC) and defect-rich (D)- Through the use of two different types of electrodes (counter electrode: platinum wire; reference electrode: Hg/ HgO), the electrocatalytic performances of D-Co(OH) 2 /CC for TCL detection were investigated, and Co(OH) 2 /CC detected TCL well and has no effect on TCL sensing with various interferers such as the VB (Vitamin B) family and amino acids (Figure 15a-b). In the H 2 O 2 sensing system, the outstanding electrocatalytic activity for H 2 O 2 assay was demonstrated by the cathodic current density rising intimately with the increase in H 2 O 2 concentration (Figure 15c), and Co(OH) 2 /CC was also unaffected by the detection of H 2 O 2 when tested against continuous drops of 500 μM such as UA (uric acid), AA (ascorbic acid) or glucose (Figure 15d).…”