Constructing a prognostic model based on MPT-related genes and investigate the characteristics of immune infiltration in bladder cancer

Abstract

Purpose: Exploring the expression of Mitochondrial Permeability Transition Dependent Necrosis lncRNAs (MPTDNLs) in bladder cancer and elucidate their precise function within the tumor microenvironment and impact on prognosis. Methods: We employed a comprehensive bioinformatics approach to investigate MPTDNLs in bladder cancer. Gene expression data, clinical data, and mutation data of bladder cancer were obtained from TCGA database. Results: We developed a new prognostic model incorporating 6 lncRNAs. The predictive efficacy of this model for bladder cancer prognosis was validated. Furthermore, through this prognostic model, we investigated the influence of MPTDNLs on the tumor microenvironment and drug sensitivity. Conclusion: This study presents a novel prognostic framework for bladder cancer that holds great potential for enhancing prognostic prediction accuracy and optimizing treatment strategies for patients with this disease.