Constructing stimuli-free self-healing, robust and ultrasensitive biocompatible hydrogel sensors with conductive cellulose nanocrystals

Song, Meili; Yu, Hou‐Yong; Zhu, Jiaying; Ouyang, Zhaofeng; Abdalkarim, Somia Yassin Hussain; Tam, Kam Chiu; Li, Yingzhan

doi:10.1016/j.cej.2020.125547

Cited by 189 publications

(112 citation statements)

References 45 publications

Supporting

Mentioning

105

Contrasting

Order By: Relevance

“…(2) It is difficult to prepare sensors with uniform performance on a large scale; (3) They lack excellent repeatability and robustness, and are often accompanied by poor reliability and life span; (4) The lack of standards makes it difficult for them to be accepted by the general public and the development of production standards will help reduce manufacturing time and final manufacturing costs; (5) The development of flexible integrated circuits and flexible batteries has limited the practical application of TMSs. Once all these challenges are met, mass production of e-textiles will become a reality, which will be a major milestone for wearable devices.…”

Section: Challenges and Prospectsmentioning

confidence: 99%

“…Flexible materials usually feature softness, easy deformation, and light weight [2,3]. Some novel flexible materials exhibit unique properties such as self-healing, hydrophobicity, biocompatibility, and biodegradability [4][5][6], which make them more competitive when compared with rigid mechanical sensors [7][8][9][10]. Textile materials are considered as promising new versions of silicon wafers in wearable electronics, not only because they have the properties of most flexible materials, but also because they hold the advantages of low cost, good conformality, comfort, and wearability [11].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Textile-Based Mechanical Sensors: A Review

et al. 2021

View full text Add to dashboard Cite

Innovations related to textiles-based sensors have drawn great interest due to their outstanding merits of flexibility, comfort, low cost, and wearability. Textile-based sensors are often tied to certain parts of the human body to collect mechanical, physical, and chemical stimuli to identify and record human health and exercise. Until now, much research and review work has been carried out to summarize and promote the development of textile-based sensors. As a feature, we focus on textile-based mechanical sensors (TMSs), especially on their advantages and the way they achieve performance optimizations in this review. We first adopt a novel approach to introduce different kinds of TMSs by combining sensing mechanisms, textile structure, and novel fabricating strategies for implementing TMSs and focusing on critical performance criteria such as sensitivity, response range, response time, and stability. Next, we summarize their great advantages over other flexible sensors, and their potential applications in health monitoring, motion recognition, and human-machine interaction. Finally, we present the challenges and prospects to provide meaningful guidelines and directions for future research. The TMSs play an important role in promoting the development of the emerging Internet of Things, which can make health monitoring and everyday objects connect more smartly, conveniently, and comfortably efficiently in a wearable way in the coming years.

show abstract

Section: Challenges and Prospectsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Textile-Based Mechanical Sensors: A Review

et al. 2021

View full text Add to dashboard Cite

show abstract

“…In situ polymerization of conductive polymer monomers onto nanostructured flexible templates (CNF, CNC) to synthesize hydrogels with a stable, flexible, continuous conductive network thereby improves electrochemical and mechanical properties of the hydrogels [218][219][220][221]. Han et al [222] prepared PANI/CNF nanocomposites by dispersing aniline on CNFs by in situ polymerization. Then, the nanocomposite was introduced into the borax cross-linked PVA hydrogel to prepare a self-healing hydrogel with good ductility and excellent conductivity (Figure 7a).…”

Section: Self-healing Hydrogel With Conductive Polymersmentioning

confidence: 99%

Self-Healing Mechanism and Conductivity of the Hydrogel Flexible Sensors: A Review

Zhang

Wang

Wei

et al. 2021

Gels

View full text Add to dashboard Cite

Sensors are devices that can capture changes in environmental parameters and convert them into electrical signals to output, which are widely used in all aspects of life. Flexible sensors, sensors made of flexible materials, not only overcome the limitations of the environment on detection devices but also expand the application of sensors in human health and biomedicine. Conductivity and flexibility are the most important parameters for flexible sensors, and hydrogels are currently considered to be an ideal matrix material due to their excellent flexibility and biocompatibility. In particular, compared with flexible sensors based on elastomers with a high modulus, the hydrogel sensor has better stretchability and can be tightly attached to the surface of objects. However, for hydrogel sensors, a poor mechanical lifetime is always an issue. To address this challenge, a self-healing hydrogel has been proposed. Currently, a large number of studies on the self-healing property have been performed, and numerous exciting results have been obtained, but there are few detailed reviews focusing on the self-healing mechanism and conductivity of hydrogel flexible sensors. This paper presents an overview of self-healing hydrogel flexible sensors, focusing on their self-healing mechanism and conductivity. Moreover, the advantages and disadvantages of different types of sensors have been summarized and discussed. Finally, the key issues and challenges for self-healing flexible sensors are also identified and discussed along with recommendations for the future.

show abstract

“…Of the many conductive polymer materials, polyaniline (PANI) exhibits good conductivity, has a simple modification process, and can be easily combined with other hydrogel materials ( Guimard et al, 2007 ; Pan et al, 2012 ; Zhai et al, 2013 ; Bagheri et al, 2020 ; Chu et al, 2020 ; Song et al, 2020 ). Thus, this material has been extensively studied for bioelectrical sensing and electrochemical detection ( Pan et al, 2012 ; Zhai et al, 2013 ).…”

Section: Introductionmentioning

confidence: 99%

A Novel Conductive Antibacterial Nanocomposite Hydrogel Dressing for Healing of Severely Infected Wounds

et al. 2021

View full text Add to dashboard Cite

Wound infections are serious medical complications that can endanger human health. Latest researches show that conductive composite materials may make endogenous/exogenous electrical stimulation more effective, guide/comb cell migration to the wound, and subsequently promote wound healing. To accelerate infected wound healing, a novel medical silver nanoparticle-doped conductive polymer-based hydrogel system (Ag NPs/CPH) dressing with good conductivity, biocompatibility, and mechanical and antibacterial properties was fabricated. For the hydrogel dressing, Ag NPs/CPH, polyvinyl alcohol (PVA), and gelatin were used as the host matrix materials, and phytic acid (PA) was used as the cross-linking agent to introduce conductive polyaniline into the matrix, with antibacterial Ag NPs loaded via impregnation. After a series of analyses, the material containing 5 wt% of PVA by concentration, 1.5 wt% gelatin, 600 μL of AN reactive volume, and 600 μL of PA reactive volume was chosen for Ag NPs/CPH preparation. XPS and FTIR analysis had been further used to characterize the composition of the prepared Ag NPs/CPH. The test on the swelling property showed that the hydrogels had abundant pores with good water absorption (≈140% within 12 h). They can be loaded and continuously release Ag NPs. Thus, the prepared Ag NPs/CPH showed excellent antibacterial property with increasing duration of immersion of Ag NPs. Additionally, to evaluate in vivo safety, CCK-8 experiments of HaCat, LO2 and 293T cells were treated with different concentrations of the Ag NPs/CPH hydrogel soaking solution. The experimental results showed the Ag NPs/CPH had no significant inhibitory effect on any of the cells. Finally, an innovative infection and inflammation model was designed to evaluate the prepared Ag NPs/CPH hydrogel dressing for the treatment of severely infected wounds. The results showed that even when infected with bacteria for long periods of time (more than 20 h), the proposed conductive antibacterial hydrogel could treat severely infected wounds.

show abstract

Constructing stimuli-free self-healing, robust and ultrasensitive biocompatible hydrogel sensors with conductive cellulose nanocrystals

Cited by 189 publications

References 45 publications

Textile-Based Mechanical Sensors: A Review

Textile-Based Mechanical Sensors: A Review

Self-Healing Mechanism and Conductivity of the Hydrogel Flexible Sensors: A Review

A Novel Conductive Antibacterial Nanocomposite Hydrogel Dressing for Healing of Severely Infected Wounds

Contact Info

Product

Resources

About