Abstract:BackgroundLAIR-1 can be triggered by collagen and its intracellular ITIMs are crucial for the inhibitory signal to NK cells. In order to investigate the regulation mechanisms of LAIR-1/collagen on NK cells, we aimed to construct LAIR-1 over-expressed NK-92 cells with which STATs related analysis was performed.MethodsLentivirus-mediated transfection was used to construct LAIR-1 over-expressed NK-92 cells. The expression of LAIR-1 in the constructed NK-92 cells was identified by QPCR and Western blot analysis. I… Show more
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