In the design and construction of buildings and infrastructures, the reconstruction of a reliable 3D engineering geological model is an essential step to optimize costs of the construction and limit risks from failure or damage due to unforeseen ground conditions. The modeling of ground conditions is a challenging issue to be tackled especially in the case of geological units with complex geometries and spatially variable geotechnical properties. In such a direction, coupled geological and geotechnical criteria are usually adopted to define engineering geological units.These concepts are considered by the current technical rules for geotechnical design such as the Eurocode 7 and in the national regulations which have followed it, known in Italy as “Norme Tecniche per le Costruzioni (NTC).” Notwithstanding this advanced regulatory framework, no comprehensive indications on methodological approaches were given for the 3D engineering geological modeling and geotechnical characterization of a design and construction site. In this paper, the case study of the highly heterogeneous and heteropic pyroclastic-alluvial stratigraphic setting of the Nola plain (Campania, southern Italy) characterizing the site of the Nola’s logistic plant is dealt with. The approaches are based on the engineering geological modeling analysis of a high number of stratigraphic, laboratory and in situ geotechnical data, collected for the design of the plant, and the use of a specialized modeling software providing advanced capabilities in spatial modeling of geological and geotechnical information, as well as in their visual representation. The results obtained, including also the analysis of statistical variability of geotechnical properties and the identification of representative geotechnical values, can be potentially considered a methodological approach, consistent with the current technical rules for geotechnical design as well as with fundamental concepts of engineering geological modeling and mapping.