Construction and application of adenoviral vectors

Zhang, Hongbo; Wang, Hongdan; An, Youcai; Chen, Ze

doi:10.1016/j.omtn.2023.09.004

Cited by 16 publications

(2 citation statements)

References 247 publications

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“…Adeno-associated viral vectors have low immunogenicity and high transduction efficiency, and they are non-pathogenic ( Shirley et al, 2020 ). A disadvantage of adenoviral vectors is a humoral response that prevents reactivation of transgene expression after repeated administration ( Zhang et al, 2023 ).…”

Section: Protein and Gene Therapy For Bone Tissue Regenerationmentioning

confidence: 99%

Application of BMP-2 and its gene delivery vehicles in dentistry

Kuznetsova,

Vasilyev,

Bukharova

et al. 2024

The Saudi Dental Journal

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Section: Protein and Gene Therapy For Bone Tissue Regenerationmentioning

confidence: 99%

Application of BMP-2 and its gene delivery vehicles in dentistry

Kuznetsova,

Vasilyev,

Bukharova

et al. 2024

The Saudi Dental Journal

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“…Adenoviral vectors, derived from various species and boasting over 100 different serotypes [131], exhibit a versatile nature that allows them to be employed for transferring genetic material into both dividing and non-dividing cells [128]. Notably, adenoviruses such as type 2 and 5 possess low host specificity, enabling their utilization in gene delivery across a wide range of tissues [120].…”

Section: Virus-based Delivery Systemmentioning

confidence: 99%

RNA Combined with Nanoformulation to Advance Therapeutic Technologies

Lima,

dos Santos,

Souza

et al. 2023

Pharmaceuticals

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Nucleic acid-based therapies have the potential to address numerous diseases that pose significant challenges to more traditional methods. RNA-based therapies have emerged as a promising avenue, utilizing nanoformulation treatments to target a range of pathologies. Nanoformulation offers several advantages compared to other treatment modalities, including targeted delivery, low toxicity, and bioactivity suitable for drug loading. At present, various types of nanoformulations are available, such as liposomes, polymeric nanoparticles (NPs), magnetic NPs, nanoshells, and solid lipid nanoparticles (SLNs). RNA-based therapy utilizes intracellular gene nanoparticles with messenger RNA (mRNA) emerging prominently in cancer therapy and immunotechnology against infectious diseases. The approval of mRNA-based technology opens doors for future technological advancements, particularly self-amplifying replicon RNA (repRNA). RepRNA is a novel platform in gene therapy, comprising viral RNA with a unique molecular property that enables the amplification of all encoded genetic information countless times. As a result, repRNA-based therapies have achieved significant levels of gene expression. In this context, the primary objective of this study is to furnish a comprehensive review of repRNA and its applications in nanoformulation treatments, with a specific focus on encapsulated nanoparticles. The overarching goal is to provide an extensive overview of the use of repRNA in conjunction with nanoformulations across a range of treatments and therapies.

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Unleashing the potential of mRNA: Overcoming delivery challenges with nanoparticles

Chen,

Huo,

et al. 2024

Bioengineering & Transla Med

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Messenger RNA (mRNA) has emerged as a promising therapeutic strategy for various diseases, including cancer, infectious diseases, and genetic disorders. The mRNA‐based therapeutics have gained significant attention due to their ability to regulate targeted cells, activate immune cells, and avoid potential risks associated with DNA‐based technology. However, the clinical application of mRNA in cancer therapy is hindered by the instability of RNA, physiological barriers, and the risk of immunogenic hurdles. To overcome these challenges and ensure the safe delivery of mRNA therapeutics to target sites, nanoparticle‐based delivery systems have been explored as potential tools in vitro and in vivo applications. This review provides a comprehensive overview of the current status of mRNA therapy, discussing its advantages and limitations, delivery strategies and materials, as well as applications in different fields. By exploring these aspects, the researcher can gain a more complete understanding of the current state, prospects, and challenges of mRNA technologies.

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Construction and application of adenoviral vectors

Cited by 16 publications

References 247 publications

Application of BMP-2 and its gene delivery vehicles in dentistry

Application of BMP-2 and its gene delivery vehicles in dentistry

RNA Combined with Nanoformulation to Advance Therapeutic Technologies

Unleashing the potential of mRNA: Overcoming delivery challenges with nanoparticles

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