Construction and application of therapeutic metal-polyphenol capsule for peripheral artery disease

Duan, Jianwei; Chen, Zuoguan; Liang, Xiaoyu; Chen, Youlu; Li, Huiyang; Tian, Xinxin; Zhang, Mingming; Wang, Xiaoli; Sun, Hongfan; Kong, Deling; Li, Yongjun; Yang, Jing

doi:10.1016/j.biomaterials.2020.120199

Cited by 78 publications

(58 citation statements)

References 57 publications

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“…Apart from the above biomedical applications, the polyphenolcontaining materials were also applied for treating peripheral artery disease, [232] facilitating the endosomal escape and the controlled pulmonary deposition of NPs, [233,234] controlling hemostasis, [235] etc. The recent years have witnessed a surge in the number of polyphenol-containing nanomaterials for a very broad range of biomedical applications, and it is believed that more interesting and important applications are emerging now and will emerge in the near future in the related field.…”

Section: Other Biomedical Applicationsmentioning

confidence: 99%

Polyphenol‐Containing Nanoparticles: Synthesis, Properties, and Therapeutic Delivery

et al. 2021

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Polyphenols, the phenolic hydroxyl group-containing organic molecules, are widely found in natural plants and have shown beneficial effects on human health. Recently, polyphenol-containing nanoparticles have attracted extensive research attention due to their antioxidation property, anticancer activity, and universal adherent affinity, and thus have shown great promise in the preparation, stabilization, and modification of multifunctional nanoassemblies for bioimaging, therapeutic delivery, and other biomedical applications. Additionally, the metal−polyphenol networks, formed by the coordination interactions between polyphenols and metal ions, have been used to prepare an important class of polyphenol-containing nanoparticles for surface modification, bioimaging, drug delivery, and disease treatments. By focusing on the interactions between polyphenols and different materials (e.g., metal ions, inorganic materials, polymers, proteins, and nucleic acids), a comprehensive review on the synthesis and properties of the polyphenol-containing nanoparticles is provided. Moreover, the remarkable versatility of polyphenol-containing nanoparticles in different biomedical applications, including biodetection, multimodal bioimaging, protein and gene delivery, bone repair, antibiosis, and cancer theranostics is also demonstrated. Finally, the challenges faced by future research regarding the polyphenol-containing nanoparticles are discussed.

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Section: Other Biomedical Applicationsmentioning

confidence: 99%

Polyphenol‐Containing Nanoparticles: Synthesis, Properties, and Therapeutic Delivery

et al. 2021

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“…, Mn, Cu, Sr, etc. ) have been shown to possess good antioxidant properties, however, most of them are rarely studied [ [18] , [19] , [20] ], suggesting a multitude of possibilities in exploiting the benefits of these metal ions to fabricate Ti implant coatings.…”

Section: Introductionmentioning

confidence: 99%

High proportion strontium-doped micro-arc oxidation coatings enhance early osseointegration of titanium in osteoporosis by anti-oxidative stress pathway

Shen

Fang

Yie

et al. 2022

Bioactive Materials

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The excessive accumulation of reactive oxygen species (ROS) under osteoporosis precipitates a microenvironment with high levels of oxidative stress (OS). This could significantly interfere with the bioactivity of conventional titanium implants, impeding their early osseointegration with bone. We have prepared a series of strontium (Sr)-doped titanium implants via micro-arc oxidation (MAO) to verify their efficacy and differences in osteoinduction capabilities under normal and osteoporotic (high OS levels) conditions. Apart from the chemical composition, all groups exhibited similar physicochemical properties (morphology, roughness, crystal structure, and wettability). Among the groups, the low Sr group (Sr25%) was more conducive to osteogenesis under normal conditions. In contrast, by increasing the catalase (CAT)/superoxide dismutase (SOD) activity and decreasing ROS levels, the high Sr-doped samples (Sr75% and Sr100%) were superior to Sr25% in inducing osteogenic differentiation of MC3T3-E1 cells and the M2 phenotype polarization of RAW264.7 cells, thus enhancing early osseointegration. Furthermore, the results of both in vitro cell co-culture and in vivo studies also showed that the high Sr-doped samples (especially Sr100%) had positive effects on osteoimmunomodulation under the OS microenvironment. Ultimately, the collated findings indicated that the high proportion Sr-doped MAO coatings were more favorable for osteoporosis patients in implant restorations.

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“…1 g). According to previous studies [ 28 ], a 40 μM H 2 O 2 concentration was chosen to mimic the in vivo ischemic micro-environment. Additionally, the release kinetics of pDNA from nanoparticle/pDNA complexes at higher concentration of H 2 O 2 (200 μM) was also determined.…”

Section: Resultsmentioning

confidence: 99%

ROS-responsive nanoparticle-mediated delivery of CYP2J2 gene for therapeutic angiogenesis in severe hindlimb ischemia

Gui

Chen

Diao

et al. 2022

Materials Today Bio

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With critical limb ischemia (CLI) being a multi-factorial disease, it is becoming evident that gene therapy with a multiple bio-functional growth factor could achieve better therapeutic outcomes. Cytochrome P450 epoxygenase-2J2 (CYP2J2) and its catalytic products epoxyeicosatrienoic acids (EETs) exhibit pleiotropic biological activities, including pro-angiogenic, anti-inflammatory and cardiovascular protective effects, which are considerably beneficial for reversing ischemia and restoring local blood flow in CLI. Here, we designed a nanoparticle-based pcDNA3.1-CYP2J2 plasmid DNA (pDNA) delivery system (nanoparticle/pDNA complex) composed of a novel three-arm star block copolymer (3S-PLGA-po-PEG), which was achieved by conjugating three-armed PLGA to PEG via the peroxalate ester bond. Considering the multiple bio-functions of CYP2J2-EETs and the sensitivity of the peroxalate ester bond to H 2 O 2 , this nanoparticle-based gene delivery system is expected to exhibit excellent pro-angiogenic effects while improving the high oxidative stress and inflammatory micro-environment in ischemic hindlimb. Our study reports the first application of CYP2J2 in the field of therapeutic angiogenesis for CLI treatment and our findings demonstrated good biocompatibility, stability and sustained release properties of the CYP2J2 nano-delivery system. In addition, this nanoparticle-based gene delivery system showed high transfection efficiency and efficient VEGF expression in vitro and in vivo. Intramuscular injection of nanoparticle/pDNA complexes into mice with hindlimb ischemia resulted in significant rapid blood flow recovery and improved muscle repair compared to mice treated with naked pDNA. In summary, 3S-PLGA-po-PEG/CYP2J2-pDNA complexes have tremendous potential and provide a practical strategy for the treatment of limb ischemia. Moreover, 3S-PLGA-po-PEG nanoparticles might be useful as a potential non-viral carrier for other gene delivery applications.

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Construction and application of therapeutic metal-polyphenol capsule for peripheral artery disease

Cited by 78 publications

References 57 publications

Polyphenol‐Containing Nanoparticles: Synthesis, Properties, and Therapeutic Delivery

Polyphenol‐Containing Nanoparticles: Synthesis, Properties, and Therapeutic Delivery

High proportion strontium-doped micro-arc oxidation coatings enhance early osseointegration of titanium in osteoporosis by anti-oxidative stress pathway

ROS-responsive nanoparticle-mediated delivery of CYP2J2 gene for therapeutic angiogenesis in severe hindlimb ischemia

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