Construction and characterization of a pure protein hydrogel for drug delivery application

Xu, Xu; Xu, Zhaokang; Yang, Xiaofeng; He, Yongqing; Lin, Rong

doi:10.1016/j.ijbiomac.2016.11.028

Cited by 34 publications

(17 citation statements)

References 27 publications

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“…These entanglements are often reversible and can be dissolved by changing the environmental conditions, such as the pH, ionic strength of the solution, or temperature. Therefore, hydrogels offer numerous advantages and can be used for the controlled release of pharmaceuticals [5].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of bacterial cellulose and gelatin-based hydrogel composites for drug-delivery systems

Treesuppharat

Rojanapanthu

Siangsanoh

et al. 2017

Biotechnology Reports

231

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Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of bacterial cellulose and gelatin-based hydrogel composites for drug-delivery systems

Treesuppharat

Rojanapanthu

Siangsanoh

et al. 2017

Biotechnology Reports

231

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“…Compared to hydrogels before degradation, the pore size of the hydrogels after biodegradation increased largely and some of the walls were broken. Xu et al prepared an injectable hydrogel based on two recombinant proteins (ULD-TIP1 and ULD-GGGWRESAI) and found this hydrogel could exhibit a relatively quick degradation rate even in the pure phosphate buffer saline (PBS) buffer [38]. Their studies showed the hydrogel was almost dissolved and/or degraded after 144 h in the pure PBS solution, which was too fast to meet requirements in the practical application.…”

Section: Resultsmentioning

confidence: 99%

Biodegradable and pH Sensitive Peptide Based Hydrogel as Controlled Release System for Antibacterial Wound Dressing Application

Zhu

Han

et al. 2018

Molecules

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The stimuli-sensitive and biodegradable hydrogels are promising biomaterials as controlled drug delivery systems for diverse biomedical applications. In this study, we construct hybrid hydrogels combined with peptide-based bis-acrylate and acrylic acid (AAc). The peptide-based bis-acrylate/AAc hybrid hydrogel displays an interconnected and porous structure by scanning electron microscopy (SEM) observation and exhibits pH-dependent swelling property. The biodegradation of hybrid hydrogels was characterized by SEM and weight loss, and the results showed the hydrogels have a good enzymatic biodegradation property. The mechanical and cytotoxicity properties of the hydrogels were also tested. Besides, triclosan was preloaded during the hydrogel formation for drug release and antibacterial studies. In summary, the peptide-based bis-acrylate/AAc hydrogel with stimuli sensitivity and biodegradable property may be excellent candidates as drug delivery systems for antibacterial wound dressing application.

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“…The porous protein hydrogels were evaluated by rheology, scanning electron microscopy (SEM) and cytotoxicity tests. Their degradation profile extended to 144 hours which is promising to extend the release of ophthalmic drugs [164].…”

Section: Newly Developed Ophthalmic Gels and In Situ Gelling Systemsmentioning

confidence: 99%

Ophthalmic gels: Past, present and future

Al-Kinani

Zidan

El-Said

et al. 2018

Advanced Drug Delivery Reviews

150

100

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Aqueous gels formulated using hydrophilic polymers (hydrogels) along with those based on stimuli responsive polymers (in situ gelling or gel forming systems) continue to attract increasing interest for various eye health-related applications. They allow the incorporation of a variety of ophthalmic pharmaceuticals to achieve therapeutic levels of drugs and bioactives at target ocular sites. The integration of sophisticated drug delivery technologies such as nanotechnology-based ones with intelligent and environment responsive systems can extend current treatment duration to provide more clinically relevant time courses (weeks and months instead of hours and days) which will inevitably reduce dose frequency, increase patient compliance and improve clinical outcomes. Novel applications and design of contact lenses and intracanalicular delivery devices along with the move towards integrating gels into various drug delivery devices like intraocular pumps, injections and implants has the potential to reduce comorbidities caused by glaucoma, corneal keratopathy, cataract, diabetic retinopathies and age-related macular degeneration. This review describes ophthalmic gelling systems with emphasis on mechanism of gel formation and application in ophthalmology. It provides a critical appraisal of the techniques and methods used in the characterization of ophthalmic preformed gels and in situ gelling systems along with a thorough insight into the safety and biocompatibility of these systems. Newly developed ophthalmic gels, hydrogels, preformed gels and in situ gelling systems including the latest in the area of stimuli responsive gels, molecularly imprinted gels, nanogels, 3D printed hydrogels; 3D printed devices comprising ophthalmic gels are covered. Finally, new applications of gels in the production of artificial corneas, corneal wound healing and hydrogel contact lenses are described.

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Construction and characterization of a pure protein hydrogel for drug delivery application

Cited by 34 publications

References 27 publications

Synthesis and characterization of bacterial cellulose and gelatin-based hydrogel composites for drug-delivery systems

Synthesis and characterization of bacterial cellulose and gelatin-based hydrogel composites for drug-delivery systems

Biodegradable and pH Sensitive Peptide Based Hydrogel as Controlled Release System for Antibacterial Wound Dressing Application

Ophthalmic gels: Past, present and future

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