Construction and characterization of immunoliposomes targeting fibroblast growth factor receptor 3

Zheng, Zhong; Ji, Haotian; Zong, Wenbo; Ran, Qiuju; Wang, Xinxin; Yang, Xi; Zhuo, Zhao; Yang, Chengjun; Xiao, Yong

doi:10.1186/s13568-019-0875-5

Cited by 9 publications

(2 citation statements)

References 24 publications

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“…However, such efficiency is not globally recognized. Its specific structural prerequisites does not involve simple function of secondary structural context, orientation, and distance between PEGylation site and salt bridge, or salt-bridge residue identity [ 5 , 20 ].…”

Section: Effects Of Pegylation On Protein Stabilitymentioning

confidence: 99%

Protein PEGylation: Navigating Recombinant Protein Stability, Aggregation, and Bioactivity

Zuma

Gasa

Makhoba

et al. 2022

BioMed Research International

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Enzymes play a powerful role as catalysts with high specificity and activity under mild environmental conditions. Significant hurdles, such as reduced solubility, reduced shelf-life, aggregate formation, and toxicity, are still ongoing struggles that scientists come across when purifying recombinant proteins. Over the past three decades, PEGylation techniques have been utilized to significantly overcome low solubility; increased protein stability, shelf-life, and bioactivity; and prevented protein aggregate formation. This review seeks to highlight the impact of PEG-based formulations that are significantly utilized to obtain favourable protein physiochemical properties. The authors further discuss other techniques that can be employed such as coexpression studies and nanotechnology-based skills to obtaining favourable protein physiochemical properties.

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Section: Effects Of Pegylation On Protein Stabilitymentioning

confidence: 99%

Protein PEGylation: Navigating Recombinant Protein Stability, Aggregation, and Bioactivity

Zuma

Gasa

Makhoba

et al. 2022

BioMed Research International

View full text Add to dashboard Cite

show abstract

“…Zheng et al 40 synthesized ScFv modified liposomes with an additional C-terminal cysteine residue, to target fibroblast growth factor receptor 3 (FGFR3). RT112 and T24 bladder cancer cell lines were chosen as high FGFR3-expressing and low FGFR3-expressing cell lines, respectively.…”

Section: Antibodiesmentioning

confidence: 99%

Dual-Targeting and Stimuli-Triggered Liposomal Drug Delivery in Cancer Treatment

AlSawaftah¹,

Pitt

Husseini³

2021

ACS Pharmacol. Transl. Sci.

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The delivery of chemotherapeutics to solid tumors using smart drug delivery systems (SDDSs) takes advantage of the unique physiology of tumors (i.e., disordered structure, leaky vasculature, abnormal extracellular matrix (ECM), and limited lymphatic drainage) to deliver anti-cancer drugs with reduced systemic side effects. Liposomes are the most promising of such SDDSs and have been well investigated for cancer therapy. To improve the specificity, bioavailability and anti-cancer efficacy of liposomes at the diseased sites, other strategies such as targeting ligands and stimulus-sensitive liposomes have been developed. This review highlights relevant surface functionalization techniques and stimuli-mediated drug release for enhanced delivery of anti-cancer agents at tumor sites, with a special focus on dual functionalization and design of multi-stimuli responsive liposomes.

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Construction Strategy of Functionalized Liposomes and Multidimensional Application

Wang,

Lan,

Zhu

et al. 2024

Small

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Liposomes are widely used in the biological field due to their good biocompatibility and surface modification properties. With the development of biochemistry and material science, many liposome structures and their surface functional components have been modified and optimized one by one, pushing the liposome platform from traditional to functionalized and intelligent, which will better satisfy and expand the needs of scientific research. However, a main limiting factor effecting the efficiency of liposomes is the complicated environmental conditions in the living body. Currently, in order to overcome the above problem, functionalized liposomes have become a very promising strategy. In this paper, binding strategies of liposomes with four main functional elements, namely nucleic acids, antibodies, peptides, and stimuli‐responsive motif have been summarized for the first time. In addition, based on the construction characteristics of functionalized liposomes, such as drug‐carrying, targeting, long‐circulating, and stimulus‐responsive properties, a comprehensive overview of their features and respective research progress are presented. Finally, the paper critically presents the limitations of these functionalized liposomes in the current applications and also prospectively suggests the future development directions, aiming to accelerate realization of their industrialization.

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Construction and characterization of immunoliposomes targeting fibroblast growth factor receptor 3

Cited by 9 publications

References 24 publications

Protein PEGylation: Navigating Recombinant Protein Stability, Aggregation, and Bioactivity

Protein PEGylation: Navigating Recombinant Protein Stability, Aggregation, and Bioactivity

Dual-Targeting and Stimuli-Triggered Liposomal Drug Delivery in Cancer Treatment

Construction Strategy of Functionalized Liposomes and Multidimensional Application

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