Urbanization and related construction activities generate massive construction and demolition (C&D) waste, which poses considerable risks to the environment and human health. However, it is difficult to assess the significance of these issues without a quantitative understanding of spatial patterns of C&D waste generation (source), transportation (flow), and treatment (sink). This paper maps source, sinks, and flows of C&D waste by coupling a geographic information system and material flow analysis. The methodology is new in the field of C&D waste quantification at the city level, especially downscaling to 5 km × 5 km grids. The results showed that a total of 37.72 million metric tonnes (Mt) of C&D wastes were generated in Beijing, 2019, and ~72% of them were reused and recycled. In space, C&D waste generation in suburban and rural districts (28.73 Mt) was over three times more than that in the downtown area (8.99 Mt). However, the downtown area was the net source region and transported massive amounts of C&D waste to suburban and rural districts. In comparison, several suburban and rural districts had self-sufficient treatment capacity. Our study highlights that a series of C&D waste maps on multiple spatial scales are of great help to design effective policies for waste management by providing spatial details of magnitude and components, and explicitly recognizing primary source and sink areas in cities.