2024
DOI: 10.1021/acs.analchem.4c00709
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Construction and Preliminary Evaluation of Two 18F-Labeled Radiopharmaceuticals for Myocardial Perfusion Imaging

Xinmiao Lu,
Xiaohui Deng,
Fei Kong
et al.

Abstract: Aims: PET myocardial perfusion imaging (MPI) is the gold standard for the noninvasive diagnosis of ischemic myocardial. Construction of 18 F-labeled PET MPI probe showed benefits to reduce the imaging cost, and enhance the image quality and patientfriendliness. Methods: Two 18 F-labeled MPI probes ( 18 F-BoMPI) were developed. Detailed in vitro/vivo evaluation including photophysical properties, in vitro stability, myocardial cell uptake kinetics and mechanisms, cytotoxicity and IC50, biodistribution and plasm… Show more

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