Construction, application and biosafety of silver nanocrystalline chitosan wound dressing

Lu, Shuang-Yun; Gao, Wenjuan; Gu, Hai Ying

doi:10.1016/j.burns.2007.08.020

Cited by 186 publications

(94 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…79 A chitosan-nanocrystalline silver dressing showed superior healing rates (89%) compared with silver sulfadiazine dressings (68%) and chitosan film (74%). 80 In addition, the chitosan-nanocrystalline silver dressing deposited far less silver than did conventional silver sulfadiazine, 80 thus demonstrating that the use of silver nanoparticles may be safer in reducing the incidence of argyria and argyremia (elevated silver concentration in the blood).…”

Section: Wound Dressings Impregnated With Silver Nanoparticlesmentioning

confidence: 99%

Silver Nanoparticles as Real Topical Bullets for Wound Healing

Gunasekaran¹,

Nigusse

Dhanaraju³

2011

Journal of the American College of Clinical Wound Specialists

180

110

View full text Add to dashboard Cite

Nanotechnology is on the threshold of providing a host of new materials and approaches, revolutionizing the medical and pharmaceutical fields. Several areas of medical care are already profiting from the advantage that nanotechnology offers. Recently, silver nanoparticles are attracting interest for a clinical application because of its potential biological properties such as antibacterial activity, anti-inflammatory effects, and wound healing efficacy, which could be exploited in developing better dressings for wounds and ulcers. This article reviews the role of silver nanoparticles in wound healing.

show abstract

Section: Wound Dressings Impregnated With Silver Nanoparticlesmentioning

confidence: 99%

Silver Nanoparticles as Real Topical Bullets for Wound Healing

Gunasekaran¹,

Nigusse

Dhanaraju³

2011

Journal of the American College of Clinical Wound Specialists

180

110

View full text Add to dashboard Cite

show abstract

“…6 To date, the most promising applications have been shown in the medical or pharmacological fields, such as biosensors 7 and wound treatment for infection. 8,9 Silver nanoparticles are available as an antimicrobial gel formulation for conventional topical antimicrobial agents, especially for burn treatment. 10 However, conventional gels and ointments have certain disadvantages, such as the need for a special application syringe to deliver the gel, which may soften or liquidate unpredictably, and move away from the treatment site rapidly.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial activity and the mechanism of silver nanoparticle thermosensitive gel

Wu¹

2011

IJN

View full text Add to dashboard Cite

Purpose:The purpose of the present study was to elucidate the antimicrobial activity and mechanism of silver nanoparticles incorporated into thermosensitive gel (S-T-Gel) on Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa. Patients and methods: This study investigated the growth, permeability, and morphology of Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa cells in order to observe the action of S-T-Gel on the membrane structure of these three bacteria. The cell morphology of normal and treated bacteria cells was assessed by transmission electron microscopy (TEM), and the effects of S-T-Gel on genome DNA of bacterial cells were evaluated by agarose gel electrophoresis. Results: S-T-Gel showed promising activity against Staphylococcus aureus and moderate activity against Escherichia coli and Pseudomonas aeruginosa. The observation with TEM suggested that S-T-Gel may destroy the structure of bacterial cell membranes in order to enter the bacterial cell. S-T-Gel then condensed DNA and combined and coagulated with the cytoplasm of the damaged bacteria, resulting in the leakage of the cytoplasmic component and the eventual death of these three bacteria. In addition, the analysis of agarose gel electrophoresis demonstrated that S-T-Gel could increase the decomposability of genome DNA. Conclusion: These results about promising antimicrobial activity and mechanism of S-T-Gel may be useful for further research and development in in-vivo studies.

show abstract

“…28 Others found that AgNPs significantly promoted wound healing of infected wounds, 29 and deep partial-thickness wounds. 30 Significant epithelial loss was detected in all groups at day 3. The loss was of 98% in group R, 95% and 93% in AV and NS groups and 74% in AV+NS group.…”

Section: Discussionmentioning

confidence: 88%

Therapeutic effect of Aloe vera and silver nanoparticles on acid-induced oral ulcer in gamma-irradiated mice

El-Batal

Ahmed

2018

Braz. oral res.

View full text Add to dashboard Cite

Radiation combined injury, a life-threatening condition, has higher mortality than simple radiation injury. The aim of the present study was to analyze the efficiency of Aloe vera and silver nanoparticles in improving the healing of ulcerated oral mucosa after irradiation. Thirty male Albino mice were divided into five groups: control, radiation, Aloe vera (AV), silver nanoparticles (NS), and AV+NS. The mice were exposed to whole body 6Gy gamma-radiation. After one hour, 20% acetic acid was injected into the submucosal layer of the lower lip for ulcer induction. The animals received topical treatment with the assigned substances for 5 days. Lip specimens were subjected to hematoxylin and eosin and anti alpha-smooth muscle actin immunohistochemical staining. Results demonstrated occurance of ulcer three days post irradiation in all groups except in the AV+NS group where only epithelial detachment was developed. After seven days, data revealed persistent ulcer in radiation group, and almost normal epithelium in the AV+NS group. A significant reduction of epithelial thickness was detected in all groups at the third day as compared to control. At the seventh day, only the AV+NS group restored the epithelial thickness. Area percent of alpha-smooth muscle actin expression was significantly decreased in radiation group at the third day followed by significant increase at the seventh day. However, all treatment groups showed significant increase in alpha-smooth muscle actin at the third day, which decreased to normal level at the seventh day. Our study demonstrated the efficiency of Aloe vera and silver nanoparticles in enhancing ulcer healing after irradiation.

show abstract

Construction, application and biosafety of silver nanocrystalline chitosan wound dressing

Cited by 186 publications

References 27 publications

Silver Nanoparticles as Real Topical Bullets for Wound Healing

Silver Nanoparticles as Real Topical Bullets for Wound Healing

Antimicrobial activity and the mechanism of silver nanoparticle thermosensitive gel

Therapeutic effect of Aloe vera and silver nanoparticles on acid-induced oral ulcer in gamma-irradiated mice

Contact Info

Product

Resources

About