Construction of a graphene/polypyrrole composite electrode as an electrochemically controlled release system

Zhu, Mo; Hao, Ying; Ma, Xun; Feng, Lin; Zhai, Yuanxin; Ding, Yaping; Cheng, Guosheng

doi:10.1039/c9ra00800d

Cited by 17 publications

(10 citation statements)

References 54 publications

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“…[7][8][9] Among them, the use of graphene scaffolds has rapidly increased in biomedicine because of the unique structure, large specific surface area, favorable biocompatibility, and excellent electrical conductivity of graphene. [10][11][12][13] Moreover, graphene scaffolds perform an active role in directing the differentiation of neural stem cells (NSCs) and reinforcing electrical signaling in neural networks. [14][15][16][17] Electrical stimulation (ES) using conductive scaffolds has been shown to promote neurite sprouting and neuronal differentiation, [18][19][20][21] ultimately facilitating the regeneration of the nervous system.…”

Section: Introductionmentioning

confidence: 99%

Strategy for Designing a Cell Scaffold to Enable Wireless Electrical Stimulation for Enhanced Neuronal Differentiation of Stem Cells

Han

Zhai

et al. 2021

Adv Healthcare Materials

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Electrical stimulation (ES) offers significant advantages in modulating the behavior of stem cells on conductive scaffolds for neural tissue engineering. However, it is necessary to realize wireless ES to avoid the use of external wires in tissues. Thus, herein, a strategy is reported to develop a stem cell scaffold that allows wireless ES. A conductive annular graphene substrate is designed and grown by chemical vapor deposition; this substrate is used as a secondary coil to achieve wireless ES via electromagnetic induction in the presence of a primary coil. The substrate shows excellent biocompatibility for the culture of neural stem cells (NSCs). The results indicate that the applied wireless ES enhances neuronal differentiation, facilitates the formation of neurites, and does not substantially affect the viability and stemness maintenance of NSCs. Collectively, this system provides a strategy for achieving synergy between wireless ES and conductive scaffolds for neural regenerative medicine, which can be further utilized for the regeneration of other tissues.

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Section: Introductionmentioning

confidence: 99%

Strategy for Designing a Cell Scaffold to Enable Wireless Electrical Stimulation for Enhanced Neuronal Differentiation of Stem Cells

Han

Zhai

et al. 2021

Adv Healthcare Materials

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“…In addition to graphene, which is a vital material in the development of bioelectronic interfaces, carbon nanomaterials, such as carbon nanotubes have been studied for their ability to serve as nano-reservoirs for targeted drug delivery. For example, Zhu et al developed a graphene/polypyrrole composite electrode (GN-PPy-FL) to release sodium fluorescein (FL) via voltage [ 114 ]. Similarly, He et al used a reduced graphene oxide (rGO)-DOX modified flexible electrode to electrophoretically deposit adriamycin (DOX) onto the rGO film and release it with a positive potential pulse [ 115 ] ( Figure 5 c).…”

Section: Applications Of Carbon Nanomaterials In the Field Of Implant...mentioning

confidence: 99%

Sensing and Stimulation Applications of Carbon Nanomaterials in Implantable Brain-Computer Interface

Cheng

et al. 2023

IJMS

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Implantable brain–computer interfaces (BCIs) are crucial tools for translating basic neuroscience concepts into clinical disease diagnosis and therapy. Among the various components of the technological chain that increases the sensing and stimulation functions of implanted BCI, the interface materials play a critical role. Carbon nanomaterials, with their superior electrical, structural, chemical, and biological capabilities, have become increasingly popular in this field. They have contributed significantly to advancing BCIs by improving the sensor signal quality of electrical and chemical signals, enhancing the impedance and stability of stimulating electrodes, and precisely modulating neural function or inhibiting inflammatory responses through drug release. This comprehensive review provides an overview of carbon nanomaterials’ contributions to the field of BCI and discusses their potential applications. The topic is broadened to include the use of such materials in the field of bioelectronic interfaces, as well as the potential challenges that may arise in future implantable BCI research and development. By exploring these issues, this review aims to provide insight into the exciting developments and opportunities that lie ahead in this rapidly evolving field.

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“…An additional requirement for such material is the presence of redox-active atoms, on which the charged antimicrobial agents can be bound. In this regard, conductive polymer coatings or polymer composites with redox-active nanomaterials are widely used [128][129][130][131]. Charging/discharging of conductive polymers (for example, polypyrrole; Figure 9) makes possible the reversible entrapping/release of a drug or release of antimicrobial agents even in a stepwise matter or pulsatile manner [132].…”

Section: Electro-responsive Coatingsmentioning

confidence: 99%

Physically Switchable Antimicrobial Surfaces and Coatings: General Concept and Recent Achievements

et al. 2021

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Bacterial environmental colonization and subsequent biofilm formation on surfaces represents a significant and alarming problem in various fields, ranging from contamination of medical devices up to safe food packaging. Therefore, the development of surfaces resistant to bacterial colonization is a challenging and actively solved task. In this field, the current promising direction is the design and creation of nanostructured smart surfaces with on-demand activated amicrobial protection. Various surface activation methods have been described recently. In this review article, we focused on the “physical” activation of nanostructured surfaces. In the first part of the review, we briefly describe the basic principles and common approaches of external stimulus application and surface activation, including the temperature-, light-, electric- or magnetic-field-based surface triggering, as well as mechanically induced surface antimicrobial protection. In the latter part, the recent achievements in the field of smart antimicrobial surfaces with physical activation are discussed, with special attention on multiresponsive or multifunctional physically activated coatings. In particular, we mainly discussed the multistimuli surface triggering, which ensures a better degree of surface properties control, as well as simultaneous utilization of several strategies for surface protection, based on a principally different mechanism of antimicrobial action. We also mentioned several recent trends, including the development of the to-detect and to-kill hybrid approach, which ensures the surface activation in a right place at a right time.

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Construction of a graphene/polypyrrole composite electrode as an electrochemically controlled release system

Abstract: A biocompatible conductive composite electrode GN–PPy–FL can realize controlled release of a drug model triggered by low voltages.

Cited by 17 publications

References 54 publications

Strategy for Designing a Cell Scaffold to Enable Wireless Electrical Stimulation for Enhanced Neuronal Differentiation of Stem Cells

Strategy for Designing a Cell Scaffold to Enable Wireless Electrical Stimulation for Enhanced Neuronal Differentiation of Stem Cells

Sensing and Stimulation Applications of Carbon Nanomaterials in Implantable Brain-Computer Interface

Physically Switchable Antimicrobial Surfaces and Coatings: General Concept and Recent Achievements

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