2024
DOI: 10.1159/000541815
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Construction of a Hybrid Vaccine Based on Der f 35-Derived Peptides with Reduced Allergenicity

Haoyang Hu,
Qiao-Zhi Qin,
Wei Zheng
et al.

Abstract: Introduction: House dust mite is the primary trigger of allergic respiratory diseases worldwide, and allergen-specific immunotherapy (AIT) is the only disease-modifying treatment in the clinic. The use of allergen molecules instead of extracts is a promising strategy in AIT. In this study, we constructed a peptide hybrid vaccine against the major mite allergen Der f 35 and verified its hypoallergenicity, making it to be a promising candidate for AIT of mite allergy. Methods: The gene encoding Der f 35 was retr… Show more

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