Construction of a Metallacyclopentadiene Ring through the Attack of Carbanions to M≡C Bond Followed by C—H Activation^†

Abstract

Comprehensive SummaryMetallacyclopentadienes are important metallacycles and regarded as intermediates in many reactions, therefore, new methods to achieve them are anticipated. In this study, a formal [3+2] method, through the reactions of an osmapentalyne with benzyl carbanions, was developed. The reactions underwent a nucleophilic attack of carbanions to the Os≡C bond, followed by C—H activation to form the five‐membered osmacyclopentadiene ring. Most of the reactions were carried out at room temperature, the substituents on the aromatic rings of benzyl carbanions are diverse, and the resulting products contain an Os—H bond, representing a novel type of 10C‐carbolong complexes. This work provides a new convenient route to construct metallacyclopentadienes, which is expected to further promote the development of such a type of substances.

Structurally Diverse Bisbenzylisoquinoline Alkaloids with Antiadipogenic Activity through PPARγ Downregulation from the Embryo of Nelumbo nucifera Seeds

“…The embryo of Nelumbo nucifera seeds is rich in BBI and aporphine alkaloids, 9,10 which are recognized as the main antiadipogenic components in lotus leaf (the dried leaf of N. nucifera, which has been proved to have significant antiobesity function). 11−15 Recently, neferine, a BBI alkaloid from the embryo of N. nucifera seeds, has been reported to possess antiadipogenic activity.…”