Construction of a Mouse Whole-Genome Radiation Hybrid Panel and Application to MMU11

Schmitt, Karin; Foster, Jamie W.; Feakes, Robert; Knights, Catherine; Davis, Maria E.; Spillett, Dominique; Goodfellow, Peter N.

doi:10.1006/geno.1996.0265

Cited by 27 publications

(8 citation statements)

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“…Human and mouse maps, based on information from Lahn and Page (1997) and Mazeyrat et al (1998), are meant to be proportionate to intergenic spacing, yet they do not necessarily reflect true physical distances. McPherson et al 1997;Schmitt et al 1996) RH panels. Stewart et al (1997) observed the centiray-tokilobase ratio to be roughly half on the Y chromosome, likely because of the increased breakage frequency of the Y.…”

Section: Comparative Mapping Of Y Chromosome Homologsmentioning

confidence: 99%

Extensive Conservation of Sex Chromosome Organization Between Cat and Human Revealed by Parallel Radiation Hybrid Mapping

Murphy¹,

Sun²,

Chen³

et al. 1999

Genome Res.

106

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A radiation hybrid (RH)-derived physical map of 25 markers on the feline X chromosome (including 19 Type I coding loci and 6 Type II microsatellite markers) was compared to homologous marker order on the human and mouse X chromosome maps. Complete conservation of synteny and marker order was observed between feline and human X chromosomes, whereas the same markers identified a minimum of seven rearranged syntenic segments between mouse and cat/human X chromosome marker order. Within the blocks, the feline, human, and mouse marker order was strongly conserved. Similarly, Y chromosome locus order was remarkably conserved between cat and human Y chromosomes, with only one marker (SMCY) position rearranged between the species. Tight linkage and a conserved gene order for a segment encoding three genes, DFFRY-DBY-UTY in human, mouse, and cat Y chromosomes, coupled with demonstrated deletion effects of these genes on reproductive impairment in both human and mouse, implicates the region as critical for Y-mediated sperm production.

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Section: Comparative Mapping Of Y Chromosome Homologsmentioning

confidence: 99%

Extensive Conservation of Sex Chromosome Organization Between Cat and Human Revealed by Parallel Radiation Hybrid Mapping

Murphy¹,

Sun²,

Chen³

et al. 1999

Genome Res.

106

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“…Although genetic mapping systems, like the interspecific crosses that have revolutionized mouse genetics, will not be created easily enough or exploited rapidly enough to yield benefits for research with other vertebrate species, radiation hybrid technology may provide strategies for gene mapping in at least some uncharted genomes (Lunetta et al 1995(Lunetta et al , 1996Gyapay et al 1996;Schmitt et al 1996). Together, these new technologies hold great promise in eventually linking human genetics and DNA sequence to functional information derived from experimental species ranging from chicken to rat, and in permitting the upcoming wave of human sequence and mapping data to mark the birth of a unified reference map for vertebrate genomes.…”

Section: Toward a Reference Map For Vertebrate Speciesmentioning

confidence: 99%

Zooming in on the Human–Mouse Comparative Map: Genome Conservation Re-examined on a High-Resolution Scale

Carver¹,

Stubbs²

1997

Genome Res.

117

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Over the past decade, conservation of genetic linkage groups has been shown in mammals and used to great advantage, fueling significant exchanges of gene mapping and functional information especially between the genomes of humans and mice. As human physical maps increase in resolution from chromosome bands to nucleotide sequence, comparative alignments of mouse and human regions have revealed striking similarities and surprising differences between the genomes of these two best-mapped mammalian species. Whereas, at present, very few mouse and human regions have been compared on the physical level, existing studies provide intriguing insights to genome evolution, including the observation of recent duplications and deletions of genes that may play significant roles in defining some of the biological differences between the two species. Although high-resolution conserved marker-based maps are currently available only for human and mouse, a variety of new methods and resources are speeding the development of comparative maps of additional organisms. These advances mark the first step toward establishment of the human genome as a reference map for vertebrate species, providing evolutionary and functional annotation to human sequence and vast new resources for genetic analysis of a variety of commercially, medically, and ecologically important animal models.

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“…The distances were calculated in centirays (cR 3000 ) using the RHMAXLIK program. The following assumptions were made: 1 cR 3000 is equivalent to a 1% probability of breakage between two markers after exposure to 3000 rad of X rays (Walter et al, 1994;Schmitt et al, 1996); 1 cR 3000 is equivalent to 0.098 Mb (McCarthy et al, 1997); 1 Mb is equivalent to 0.5 cM (Watkins-Chow et al, 1997).…”

Section: Physical Mapping Of the Sprr2 Genesmentioning

confidence: 99%

MouseSprr2Genes: A Clustered Family of Genes Showing Differential Expression in Epithelial Tissues

et al. 1999

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Construction of a Mouse Whole-Genome Radiation Hybrid Panel and Application to MMU11

Cited by 27 publications

References 0 publications

Extensive Conservation of Sex Chromosome Organization Between Cat and Human Revealed by Parallel Radiation Hybrid Mapping

Extensive Conservation of Sex Chromosome Organization Between Cat and Human Revealed by Parallel Radiation Hybrid Mapping

Zooming in on the Human–Mouse Comparative Map: Genome Conservation Re-examined on a High-Resolution Scale

MouseSprr2Genes: A Clustered Family of Genes Showing Differential Expression in Epithelial Tissues

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